Protein Alignment CYP3A4 and Cyp4ac2

DIOPT Version :8

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 110/397 (28%)
• Similarity: 202/397 (51%)
• Gaps: 24/397 (6%)

Human   113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG 177
            |:...:.|:.|::|...|..|:|.|....|:..:.|..:..:.||:.|.:  .....:.|..|..
  Fly   127 FLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQ--SVNMELELNQVIP 189

Human   178 AYSMDVITSTSFGVNIDSLNN--PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPIL--EVLNI 238
            .::::.:..|:.||.:|.|:.  .....:...:::::....:|||.:|..| ||....  :|.|:
  Fly   190 QFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF-FLFGDYRKQVNNL 253

Human   239 CVFPREVTNFLRKSVKRMKESRL--EDT--QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS 299
            .:.....:|.:.|.....|.::|  ||.  :|.|...|..::.::...:.: |:.:.|     :.
  Fly   254 KIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQID-HQGICD-----EV 312

Human   300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ---MEYLDMVVN 361
            ..|:|.||:|||:.|.|.:..||.|.|||:|..||| ..||:.:...  :|.|   :.|::.|:.
  Fly   313 NTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEI-KYLPDDSDDI--SVFQFNELVYMECVIK 374

Human   362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
            |:|||||....:.|.|.::..:||:.:||...:.|..|.:.||.::::.|:.|.|:||..:|..|
  Fly   375 ESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVN 439

Human   427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491
            ..|:.:.||.:|.|||||.:||::.:|:.|..|::||...|..... .|....|.:|:.::.:.:
  Fly   440 RHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLD-DLTFENGIVLRTKQNIKV 503

Human   492 KVESRD 497
            |:..|:
  Fly   504 KLVHRE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:306555	109/391 (28%)
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	109/391 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900				OOG5_126554
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900