Protein Alignment CYP3A4 and Cyp4ac2

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608917.3
• Gene: Cyp4ac2 / 33755
• FlyBaseID: FBgn0031694
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 396
• Identity: 110/396 - (27%)
• Similarity: 202/396 - (51%)
• Gaps: 24/396 - (6%)

Human   113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG 177
            |:...:.|:.|::|...|..|:|.|....|:..:.|..:..:.||:.|.:  .....:.|..|..
  Fly   127 FLGEGLLISTDQKWHSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQ--SVNMELELNQVIP 189

Human   178 AYSMDVITSTSFGVNIDSLNN--PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPIL--EVLNI 238
            .::::.:..|:.||.:|.|:.  .....:...:::::....:|||.:|..| ||....  :|.|:
  Fly   190 QFTLNNVCETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF-FLFGDYRKQVNNL 253

Human   239 CVFPREVTNFLRKSVKRMKESRL--EDT--QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS 299
            .:.....:|.:.|.....|.::|  ||.  :|.|...|..::.::...:.: |:.:.|     :.
  Fly   254 KIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEADGQID-HQGICD-----EV 312

Human   300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ---MEYLDMVVN 361
            ..|:|.||:|||:.|.|.:..||.|.|||:|..||| ..||:.:...  :|.|   :.|::.|:.
  Fly   313 NTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEI-KYLPDDSDDI--SVFQFNELVYMECVIK 374

Human   362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
            |:|||||....:.|.|.::..:||:.:||...:.|..|.:.||.::::.|:.|.|:||..:|..|
  Fly   375 ESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVN 439

Human   427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491
            ..|:.:.||.:|.|||||.:||::.:|:.|..|::||...|..... .|....|.:|:.::.:.:
  Fly   440 RHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLD-DLTFENGIVLRTKQNIKV 503

Human   492 KVESRD 497
            |:..|:
  Fly   504 KLVHRE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	108/389 (28%)
Cyp4ac2	NP_608917.3	CYP4	84..503	CDD:410721	108/388 (28%)