Protein Alignment CYP3A4 and Cyp309a2

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 138/519 - (26%)
• Similarity: 237/519 - (45%)
• Gaps: 80/519 - (15%)

Human     1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI--LSYHKGFCMFDME 63
            |.::..||:   :||.:.::.:|||.|..|..::|.|:....||..||..  |...|...:||::
  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ 93

Human    64 -CHKKY-GK--VWGFYDGQQPVLAITDPDMIKTVLVK--ECY--------------SVFTNRRPF 108
             .:.|| ||  ..|.:..:||.:.:.||::...|||.  .||              ..:....||
  Fly    94 KIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPF 158

Human   109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-AETGKPVTL 172
            .           |..:.|:|||:......:..:|::...|..|.|.:|...:.:: ||....:..
  Fly   159 W-----------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILET 212

Human   173 KDVFGAYSMDVITSTSFGVNIDSLNNPQD---PFVENTKKLLRFDFLDPFFLSITVFPFLIPILE 234
            :|:...|:..|:....:|::..:|..|.:   ...|...|...:.|   :.|::.:...:.|...
  Fly   213 RDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAF---YMLTLFMATIVAPCSR 274

Human   235 -VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQ 298
             :|....:|:|...|.....|...|.||:.....|.|:|..::..::.|:     |..| :||..
  Fly   275 LLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQ-----ATHD-DLVGH 333

Human   299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNET 363
            ::..:..||:|:.:.|...:|.||.:|.|||||:.||.:.:.::....::.:..::||:.|:.|:
  Fly   334 ALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYES 398

Human   364 LRL------------FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLP 416
            |||            .|..:||......|||:       |:.:|||:|..|.|.:|:.|||.|.|
  Fly   399 LRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAFKP 456

Human   417 ERFSKKNKDN------IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
            |||     ||      :...|:.||..|||.|:|:..|::.:|.||:.:|.||.....::..||
  Fly   457 ERF-----DNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	118/450 (26%)
Cyp309a2	NP_608689.2	CYP6-like	101..526	CDD:410679	116/447 (26%)