DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	138/519 - (26%)
Similarity:	237/519 - (45%)	Gaps:	80/519 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI--LSYHKGFCMFDME 63
            |.::..||:   :||.:.::.:|||.|..|..::|.|:....||..||..  |...|...:||::
  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ 93

Human    64 -CHKKY-GK--VWGFYDGQQPVLAITDPDMIKTVLVK--ECY--------------SVFTNRRPF 108
             .:.|| ||  ..|.:..:||.:.:.||::...|||.  .||              ..:....||
  Fly    94 KIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPF 158

Human   109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-AETGKPVTL 172
            .           |..:.|:|||:......:..:|::...|..|.|.:|...:.:: ||....:..
  Fly   159 W-----------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILET 212

Human   173 KDVFGAYSMDVITSTSFGVNIDSLNNPQD---PFVENTKKLLRFDFLDPFFLSITVFPFLIPILE 234
            :|:...|:..|:....:|::..:|..|.:   ...|...|...:.|   :.|::.:...:.|...
  Fly   213 RDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAF---YMLTLFMATIVAPCSR 274

Human   235 -VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQ 298
             :|....:|:|...|.....|...|.||:.....|.|:|..::..::.|:     |..| :||..
  Fly   275 LLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQ-----ATHD-DLVGH 333

Human   299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNET 363
            ::..:..||:|:.:.|...:|.||.:|.|||||:.||.:.:.::....::.:..::||:.|:.|:
  Fly   334 ALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYES 398

Human   364 LRL------------FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLP 416
            |||            .|..:||......|||:       |:.:|||:|..|.|.:|:.|||.|.|
  Fly   399 LRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAFKP 456

Human   417 ERFSKKNKDN------IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
            |||     ||      :...|:.||..|||.|:|:..|::.:|.||:.:|.||.....::..||
  Fly   457 ERF-----DNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	126/481 (26%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	126/478 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920