Protein Alignment CYP2F1 and Cyp303a1

DIOPT Version :10

• Sequence 1: NP_000765.2
• Gene: CYP2F1 / 1572
• HGNCID: 2632
• Length: 491
• Species: Homo sapiens
• Sequence 2: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 510
• Identity: 132/510 - (25%)
• Similarity: 236/510 - (46%)
• Gaps: 39/510 - (7%)

Human     8 ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLL----LLCSQDMLTSLTKL-SKEYGS--- 64
            ::.:..|.:..:|....|...:.||||....|:|:.|    |.|...|...:..: :::|.:
  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69

Human    65 MYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGD--YPAFFNFTKGNGIAFSSGDRWKVLRQF 127
            .|.:.:|..:||:.....|:.|.:.:  |:..||.|  :.....|....|:..:.|:.|...|:|
  Fly    70 FYGLKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRRF 132

Human   128 SIQILRNFGMGKRSIEERILEEGSFLLAEL---------RKTEGEPFDPTFVLSRSVSNIICSVL 183
            .::.|:|||..:..:.:.:..|.:.||.:|         ::|..|..|.|.|.   |.|.:..:|
  Fly   133 ILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVY---VLNTLWCML 194

Human   184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVP--GPHQRIFQNFKCLRDLIA 246
            .|.|::.....:..::....:.|:.:... |.|:..||.|....|  ..:....::.:.|...::
  Fly   195 SGRRYEPGSPEITQLLETFFELFKNIDMV-GALFSHFPLLRFIAPNFSGYNGFVESHRSLYTFMS 258

Human   247 HSVHDHQASL-DPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHA 310
            ..:..|:.:. :...|||.:..:| :..:|..|....|...:||....::...|::|.:.:|...
  Fly   259 KEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLGFC 322

Human   311 FLALMKYPKVQARVQEEIDLVVGRARLPA-LKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRD 374
            |:.|:..|::|.|..:||..|||..|:|. .:||..:||.:|:..|..|...:....:|||...|
  Fly   323 FMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAVCD 387

Human   375 TAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFL-DANQSFKKSPAFMPFSAGRRLCLG 438
            |...|:.|||.|.||.....:..:|..|..|:.|||:.:| |.:  .|...||.||..||..|:|
  Fly   388 TRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFDGH--LKLPEAFNPFGFGRHRCMG 450

Human   439 ESLARMELFLYLTAILQSFSLQ--PLGAPEDIDLTPLSSGLGNLPRPFQLCLRPR 491
            :.|.|..||::.|.:||:|.:.  |...||::.|...::.:    :|:.:.|..|
  Fly   451 DLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAV----KPYDIMLVAR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2F1	NP_000765.2	Cyp2F	62..486	CDD:410762	117/444 (26%)
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	116/440 (26%)