DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcn2 and CG42260

DIOPT Version :9

Sequence 1:	NP_032252.1	Gene:	Hcn2 / 15166	MGIID:	1298210	Length:	863	Species:	Mus musculus
Sequence 2:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	201/861 - (23%)
Similarity:	323/861 - (37%)	Gaps:	237/861 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    45 TTPSHPESADEP---GPRARLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRG 106
            |...||.:...|   ||..          ||...||            .|..|..|        |
  Fly   497 TVSHHPHAHGPPSQGGPGG----------PGPPHGG------------HPHHPHHG--------G 531

Mouse   107 AASGPSAAEEAGSEEAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKS 171
            |.||      .||......|:|.                            .||......:|:::
  Fly   532 AGSG------GGSGPGSHGGQPH----------------------------HQKPRRTASQRIRA 562

Mouse   172 AGA-----WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFL 229
            |.|     ::..|.....:||...:.:..:.|..:|.....|  ....|.|.|...:.:||..:|
  Fly   563 ATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYL 627

Mouse   230 MDLVLNFRTGIVIEDNTEIILDPEKIKKKYLR-TWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTA 293
            :|::.:|||| .:||.. :..|..|::..|:. |.|.:|.:..:|:|:::|
  Fly   628 IDILFHFRTG-YLEDGV-LQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYL-------------- 676

Mouse   294 RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQ 358
                .:.|..||...||:::.|...::.:.|.  |..|   ..:.|...||..:|::.||:|||.
  Fly   677 ----SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLY 732

Mouse   359 FLVPMLQDFPSDCWVSINN---------MVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDI 414
            .::.....|.|..||..::         :.::.|..|          .:..|| ....|.|..:.
  Fly   733 HIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTL----------ALTTIG-DLPKPRSKGEY 786

Mouse   415 WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEH 479
            ...:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|...:.|:..::::
  Fly   787 VFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDY 851

Mouse   480 RY-QGKMFDEDSILGELNGPLREEI-VNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGD 542
            .: ..|..||:..:..|...|:.|| :|.:...| ..:.:|.|.:..|:..::.:|:..:|.|||
  Fly   852 LWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGD 915

Mouse   543 YIIREGTIGKKMYFIQHGVVSVLTKGNKEM--KLSDGSYFGEICLLTRG----RRTASVRADTYC 601
            ||.|:|.:||:||.:..|.:.|:....|.:  .|..|||||||.:|..|    |||||||:..|.
  Fly   916 YICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYS 980

Mouse   602 RLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQENAIIQE 666
            .|:.||..:..:||:|||..|...|::|:.||::..|..   |.||::      ||
  Fly   981 DLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP---LEKVKY------FN--------- 1027

Mouse   667 IVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVGPLALGSPRLVR 731
                                                  .|||..|.            .:|.||.
  Fly  1028 --------------------------------------VVAMGRCQ------------STPGLVE 1042

Mouse   732 RAPPGP-----LPPAASPGPP-----AASPPAAPSSPRAPRTSPYGVPGSPATRVGPALPARRLS 786
            ......     ||||.:....     .|......:|.:.|.........|......|...|.||:
  Fly  1043 SCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLA 1107

Mouse   787 RASRPLSASQPSLPHGVPAPSPAASARPASSST------PRLGPAPTARTAAPSPDRRDSASP-- 843
            ||:....:..|| .||       :..||.|.:|      |:..|:.|....       ||:|.
  Fly  1108 RATDSPRSVSPS-AHG-------SEERPRSRTTSHHSIRPQSQPSHTGHIC-------DSSSQLE 1157

Mouse   844 -------GAASGLDPL 852
                   ||..|..||
  Fly  1158 CYGAGVGGAGGGTTPL 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcn2	NP_032252.1	CAP_ED	517..625	CDD:237999	46/113 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..863		34/148 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		21/88 (24%)
		Involved in subunit assembly	131..182		6/55 (11%)
		Ion_trans_N	140..182	CDD:285597	6/46 (13%)
		Ion_trans	202..447	CDD:278921	58/256 (23%)
		Crp	511..>646	CDD:223736	53/140 (38%)
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	61/273 (22%)
		CAP_ED	890..1004	CDD:237999	46/113 (41%)
		DUF4655	1084..>1154	CDD:317882	20/84 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960