Protein Alignment Hcn2 and CG42260

DIOPT Version :10

• Sequence 1: NP_032252.1
• Gene: Hcn2 / 15166
• MGIID: 1298210
• Length: 863
• Species: Mus musculus
• Sequence 2: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 861
• Identity: 201/861 - (23%)
• Similarity: 323/861 - (37%)
• Gaps: 237/861 - (27%)

Mouse    45 TTPSHPESADEP---GPRARLCSRDSACTPGAAKGGANGECGRGEPQCSPEGPARGPKVSFSCRG 106
            |...||.:...|   ||..          ||...||            .|..|..|        |
  Fly   497 TVSHHPHAHGPPSQGGPGG----------PGPPHGG------------HPHHPHHG--------G 531

Mouse   107 AASGPSAAEEAGSEEAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMFGSQKAVEREQERVKS 171
            |.||      .||......|:|.                            .||......:|:::
  Fly   532 AGSG------GGSGPGSHGGQPH----------------------------HQKPRRTASQRIRA 562

Mouse   172 AGA-----WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFL 229
            |.|     ::..|.....:||...:.:..:.|..:|.....|  ....|.|.|...:.:||..:|
  Fly   563 ATAARKLHFVFDPAGRLCYYWSMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYL 627

Mouse   230 MDLVLNFRTGIVIEDNTEIILDPEKIKKKYLR-TWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTA 293
            :|::.:|||| .:||.. :..|..|::..|:. |.|.:|.:..:|:|:::|
  Fly   628 IDILFHFRTG-YLEDGV-LQTDALKLRTHYMNSTIFYIDCLCLLPLDFLYL-------------- 676

Mouse   294 RALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQ 358
                .:.|..||...||:::.|...::.:.|.  |..|   ..:.|...||..:|::.||:|||.
  Fly   677 ----SIGFNSILRSFRLVKIYRFWAFMDRTER--HTNY---PNLFRSTALIHYLLVIFHWNGCLY 732

Mouse   359 FLVPMLQDFPSDCWVSINN---------MVNHSWSELYSFALFKAMSHMLCIGYGRQAPESMTDI 414
            .::.....|.|..||..::         :.::.|..|          .:..|| ....|.|..:.
  Fly   733 HIIHKNNGFGSRNWVYHDSESADVVKQYLQSYYWCTL----------ALTTIG-DLPKPRSKGEY 786

Mouse   415 WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEH 479
            ...:|.::.|...:|..:||...::.|:.::|:::|.|...|:.||...::|...:.|:..::::
  Fly   787 VFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPNHLQVKVIKWFDY 851

Mouse   480 RY-QGKMFDEDSILGELNGPLREEI-VNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGD 542
            .: ..|..||:..:..|...|:.|| :|.:...| ..:.:|.|.:..|:..::.:|:..:|.|||
  Fly   852 LWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTL-KRVEIFQNTEAGFLCELVLRLRPVLFSPGD 915

Mouse   543 YIIREGTIGKKMYFIQHGVVSVLTKGNKEM--KLSDGSYFGEICLLTRG----RRTASVRADTYC 601
            ||.|:|.:||:||.:..|.:.|:....|.:  .|..|||||||.:|..|    |||||||:..|.
  Fly   916 YICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNMGTAGNRRTASVRSVGYS 980

Mouse   602 RLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLSSGVFNNQENAIIQE 666
            .|:.||..:..:||:|||..|...|::|:.||::..|..   |.||::      ||
  Fly   981 DLFVLSKKDMWDVLKEYPAARVRLESIAVKRLEKYKKAP---LEKVKY------FN--------- 1027

Mouse   667 IVKYDREMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLVGPLALGSPRLVR 731
                                                  .|||..|.            .:|.||.
  Fly  1028 --------------------------------------VVAMGRCQ------------STPGLVE 1042

Mouse   732 RAPPGP-----LPPAASPGPP-----AASPPAAPSSPRAPRTSPYGVPGSPATRVGPALPARRLS 786
            ......     ||||.:....     .|......:|.:.|.........|......|...|.||:
  Fly  1043 SCGRTSLEEMWLPPATAGASSLMHHHQALQQQHQASQQQPHRQESTQTSSQTHGYSPRSYADRLA 1107

Mouse   787 RASRPLSASQPSLPHGVPAPSPAASARPASSST------PRLGPAPTARTAAPSPDRRDSASP-- 843
            ||:....:..|| .||       :..||.|.:|      |:..|:.|....       ||:|.
  Fly  1108 RATDSPRSVSPS-AHG-------SEERPRSRTTSHHSIRPQSQPSHTGHIC-------DSSSQLE 1157

Mouse   844 -------GAASGLDPL 852
                   ||..|..||
  Fly  1158 CYGAGVGGAGGGTTPL 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcn2	NP_032252.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		21/88 (24%)
		Involved in subunit assembly	131..182		6/55 (11%)
		Ion_trans_N	140..182	CDD:400630	6/46 (13%)
		PLN03192	175..>661	CDD:215625	135/505 (27%)
		CAP_ED	517..625	CDD:237999	46/113 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	730..863		34/148 (23%)
		PRK07003	<769..>862	CDD:235906	26/99 (26%)
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	62/274 (23%)
		CAP_ED	890..1004	CDD:237999	46/113 (41%)