Protein Alignment CTSV and CtsL2

DIOPT Version :10

• Sequence 1: NP_001324.2
• Gene: CTSV / 1515
• HGNCID: 2538
• Length: 334
• Species: Homo sapiens
• Sequence 2: NP_610906.1
• Gene: CtsL2 / 36531
• FlyBaseID: FBgn0033874
• Length: 352
• Species: Drosophila melanogaster
• Alignment Length: 350
• Identity: 125/350 - (35%)
• Similarity: 189/350 - (54%)
• Gaps: 28/350 - (8%)

Human     1 MNLSL-VLAAFCLGIASAVPKF--DQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELH 62
            |.|.| :|.|..|....:.||.  .||.|    .:.....::|...|..:|.:::...|.:|.|.
  Fly    11 MTLGLALLGAVSLQQLQSFPKLCDVQNFD----DFLRQTGKVYSDEERVYRESIFAAKMSLITLS 71

Human    63 NGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGC----FRNQKFRKGKV----FREPLFLDLPKSVD 119
            |.....|..||.:.:|...|||.:|...::|.    | .:::..|.:    .|.|...:||:..|
  Fly    72 NKNADNGVSGFRLGVNTLADMTRKEIATLLGSKISEF-GERYTNGHINFVTARNPASANLPEMFD 135

Human   120 WRKKGYVTPVKNQ-KQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFM 183
            ||:||.|||...| ..||:||:|:.||||||.:||:||.|.|||:||||||:...||.||:|||.
  Fly   136 WREKGGVTPPGFQGVGCGACWSFATTGALEGHLFRRTGVLASLSQQNLVDCADDYGNMGCDGGFQ 200

Human   184 ARAFQYVKENGGLDSEESYPYVAVDEICKYR------PENSVANDTGFTVVAPGKEKALMKAVAT 242
            ...|:|:::: |:.....|||...:..|:..      |..|:.....:..:.||.|:.:.:.:||
  Fly   201 EYGFEYIRDH-GVTLANKYPYTQTEMQCRQNETAGRPPRESLVKIRDYATITPGDEEKMKEVIAT 264

Human   243 VGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEW 307
            :||::.:|:|...||:.|..|||.:.:|:...|:|.|.|||||.|    |...||::|||:...|
  Fly   265 LGPLACSMNADTISFEQYSGGIYEDEECNQGELNHSVTVVGYGTE----NGRDYWIIKNSYSQNW 325

Human   308 GSNGYVKIAKDKNNHCGIATAASYP 332
            |..|:::|.::....||||:..|||
  Fly   326 GEGGFMRILRNAGGFCGIASECSYP 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTSV	NP_001324.2	Inhibitor_I29	29..87	CDD:214853	14/57 (25%)
		Peptidase_C1	114..332	CDD:425470	92/224 (41%)
CtsL2	NP_610906.1	Inhibitor_I29	38..97	CDD:462410	15/62 (24%)
		Peptidase_C1A	131..350	CDD:239068	91/223 (41%)