Protein Alignment: Gria1 and GluRIB

• Sequence 1: NP_001106796.1
• Gene: Gria1
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_001261621.2
• Gene: GluRIB
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1029
• Identity: 413/1030 (40%)
• Similarity: 563/1030 (55%)
• Gaps: 167/1030 (16%)

Mouse    14 GAVVGA----NFPNNIQIGGLFPNQQSQEHAAFRFA-----LSQLTEPPKLLPQIDIVNISDSFE 69
            |:.||.    :....|.:|.:|.....:..:||::|     |:..:...:|...:|::|.:|:|:
  Fly    27 GSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFK 91

Mouse    70 MTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP--VDTSN----QFVLQLRPE 128
            ::...|:|||:|||::.|.....:.:.|.|:.....:.|:||.||  |.|.:    .|.|.:||:
  Fly    92 LSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPD 156

Mouse   129 LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLD--TAAEKNWQVTAVNILTTTEEGYRML--F 189
            ..:|:|..|..|.|:..:|:||:..||..||::..  ....:::||..|..::........|  .
  Fly   157 YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL 221

Mouse   190 QDLEKKKERLVVVDCESERLNAILGQIVK-LEKNGIGYHYILANLGFMDIDLNKFKESGA-NVTG 252
            :.:.:.:.:.:|:||.:|....||.|.|: |......|||:|:.|...|...::..|.|| |:||
  Fly   222 EQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITG 286

Mouse   253 FQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRID---- 313
            |::|:....:.......|:..|.:.......:.....:||.||.|.|:.|||..:.|::.|
  Fly   287 FRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRN 351

Mouse   314 -ISRR---------------------------GNAG---------------------DCLANPAV 329
             :.||                           ||.|                     ||  |.|.
  Fly   352 NVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC--NTAK 414

Mouse   330 ----PWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMK-HDGIRKIGYWNEDDKFV 389
                .|..|..|.|.|::|..|||||:::||:.|||.||||||:||. :..:.|:..||:|....
  Fly   415 GWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQ 479

Mouse   390 PA-ATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNA--NQFEGNDRYEGYCVELAAEIAKHVG 451
            |. |...:........:||||||||:||:||:|||:.|  .:..||:|:||||.:||..:||.:|
  Fly   480 PLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELG 544

Mouse   452 YSYRLEIVSDGKYGARDPDTK-AWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGIS 515
            .:|.|.:|.||.||:...... .|:|||||||...||:|:|.:|||..||.||||||||||||||
  Fly   545 INYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGIS 609

Mouse   516 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--------------- 565
            ||||||.|..||||||::||:.|||:.::|:|||||:|||.||||||:||
  Fly   610 IMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDP 674

Mouse   566 --HSEEF-----------------------------------------EEGRDQTTSDQSNEFGI 587
              |.|:.                                         ..|...::|...|||.:
  Fly   675 HAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSV 739

Mouse   588 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 652
            :||.||||.||||||||:||||:||||....|:|||||:||||||||||||||||||:||.|.||
  Fly   740 WNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPED 804

Mouse   653 LAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYL 717
            ||.|||:.||||..|||.:|||||:|.:..|||.||.|.: .|||.|.:||:.|||.||||||.|
  Fly   805 LAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALL 868

Mouse   718 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWY 782
            :||..|||:..|:||||||||.|||:||:|||||.||||:.|:|||||.|.|.|.|.||::||||
  Fly   869 VESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWY 933

Mouse   783 DKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQ 847
            :|.||.:...| :...|.||||||||:||||||||.:::.||::|:|::||.......|..:
  Fly   934 EKAECSTHKDG-ETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASSGSGM--- 994

Mouse   848 QSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMP 901
                      .|....|.|.||||....||         ||...|..:...|||
  Fly   995 ----------GLGMGLGGGMSGGSLGKANG---------SMMLGPSSAVPGGMP 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_001106796.1	PBP1_iGluR_AMPA_GluR1	26..389	CDD:107385	121/438 (28%)
		ANF_receptor	37..372	CDD:279440	115/409 (28%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	245/442 (55%)
		Glutamate binding. {ECO:0000250}	492..494		0/2 (0%)
		Lig_chan	538..817	CDD:278489	182/337 (54%)
		Glutamate binding. {ECO:0000250}	668..669		1/1 (100%)
		PDZ-binding	904..907
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..478	CDD:107375	121/437 (28%)
		ANF_receptor	55..461	CDD:279440	115/408 (28%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	245/442 (55%)
		Lig_chan	632..967	CDD:278489	182/337 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C111105366
eggNOG	1	0.900				E1_KOG1052
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	707	1.000	Inparanoid score	I644
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D89427at33208
OrthoFinder	1	1.000				FOG0000395
OrthoInspector	1	1.000				T130891
orthoMCL	1	0.900				OOG5_128645
Panther	1	1.100			O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	11	10.860