Protein Alignment Gria1 and GluRIB

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1029
• Identity: 415/1029 - (40%)
• Similarity: 564/1029 - (54%)
• Gaps: 167/1029 - (16%)

Mouse    14 GAVVGA----NFPNNIQIGGLFPNQQSQEHAAFRFA-----LSQLTEPPKLLPQIDIVNISDSFE 69
            |:.||.    :....|.:|.:|.....:..:||::|     |:..:...:|...:|::|.:|:|:
  Fly    27 GSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFK 91

Mouse    70 MTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP--VDTSN----QFVLQLRPE 128
            ::...|:|||:|||::.|.....:.:.|.|:.....:.|:||.||  |.|.:    .|.|.:||:
  Fly    92 LSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFALSMRPD 156

Mouse   129 LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLD--TAAEKNWQVTAVNILTTTEEGYRML--F 189
            ..:|:|..|..|.|:..:|:||:..||..||::..  ....:::||..|..::........|  .
  Fly   157 YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVELVKRISNVSMAIEFLHTL 221

Mouse   190 QDLEKKKERLVVVDCESERLNAILGQIVK-LEKNGIGYHYILANLGFMDIDLNKFKESGA-NVTG 252
            :.:.:.:.:.:|:||.:|....||.|.|: |......|||:|:.|...|...::..|.|| |:||
  Fly   222 EQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITG 286

Mouse   253 FQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRID---- 313
            |::|:....:.......|:..|.:.......:.....:||.||.|.|:.|||..:.|::.|
  Fly   287 FRIVDTNRRLVREFYDSWKRLDPQMSVGAGRESISAQAALMYDAVFVLVEAFNKILRKKPDQFRN 351

Mouse   314 -ISRR---------------------------GNAG---------------------DCLANPAV 329
             :.||                           ||.|                     ||  |.|.
  Fly   352 NVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDC--NTAK 414

Mouse   330 ----PWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMK-HDGIRKIGYWNEDDKFV 389
                .|..|..|.|.|::|..|||||:::||:.|||.||||||:||. :..:.|:..||:|....
  Fly   415 GWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQ 479

Mouse   390 PA-ATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNA--NQFEGNDRYEGYCVELAAEIAKHVG 451
            |. |...:........:||||||||:||:||:|||:.|  .:..||:|:||||.:||..:||.:|
  Fly   480 PLNAKYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELG 544

Mouse   452 YSYRLEIVSDGKYGARDPDTK-AWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGIS 515
            .:|.|.:|.||.||:...... .|:|||||||...||:|:|.:|||..||.||||||||||||||
  Fly   545 INYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGIS 609

Mouse   516 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--------------- 565
            ||||||.|..||||||::||:.|||:.::|:|||||:|||.||||||:||
  Fly   610 IMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDP 674

Mouse   566 --HSEEF-----------------------------------------EEGRDQTTSDQSNEFGI 587
              |.|:.                                         ..|...::|...|||.:
  Fly   675 HAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSV 739

Mouse   588 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 652
            :||.||||.||||||||:||||:||||....|:|||||:||||||||||||||||||:||.|.||
  Fly   740 WNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPED 804

Mouse   653 LAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYL 717
            ||.|||:.||||..|||.:|||||:|.:..|||.||.|.: .|||.|.:||:.|||.||||||.|
  Fly   805 LAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-HVFVPTYDEGIKRVRNSKGKYALL 868

Mouse   718 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWY 782
            :||..|||:..|:||||||||.|||:||:|||||.||||::|:|||||.|.|.|.|.||:|||||
  Fly   869 VESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWY 933

Mouse   783 DKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQ 847
            :|.|| |...|.:...|.||||||||:||||||||.:::.||::|:|::||.......|..:
  Fly   934 EKAEC-STHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEYCFRSRDSRSASSGSGM--- 994

Mouse   848 QSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMP 901
                      .|....|.|.||||....||         ||...|..:...|||
  Fly   995 ----------GLGMGLGGGMSGGSLGKANG---------SMMLGPSSAVPGGMP 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	122/441 (28%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	245/441 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		9/23 (39%)
		PDZ-binding	904..907
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	121/438 (28%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	245/441 (56%)
		Lig_chan	630..966	CDD:459656	182/337 (54%)