Protein Alignment Gria1 and GluRIID

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Alignment Length: 925
• Identity: 299/925 - (32%)
• Similarity: 485/925 - (52%)
• Gaps: 96/925 - (10%)

Mouse    14 GAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALS----QLTEPPKLLPQIDIVNISDSFEMTYRF 74
            |....|:...:|::|.:..:...:....|..|:|    :|..|  |:.:.:.|...:|.:...:.
  Fly    23 GNAYEASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELGVP--LVGETEQVAYGNSVQAFAQL 85

Mouse    75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS-NQFVLQLRPE-LQEALISII 137
            |.....||.|:||...|.|.:.|.:.|.:..:.||.|.....:: :.|.|...|| :..||..|:
  Fly    86 CRLMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIV 150

Mouse   138 DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV 202
            :.::|..|::.|::...|.:|..::.....|...:..:.........|:.:.:.:.|.::..:||
  Fly   151 NQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVV 215

Mouse   203 DCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIM 267
            ...:..:..:|.|..::......|.||:.||.....||.::|.|.||:||.::.:........:|
  Fly   216 VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLM 280

Mouse   268 QQWRTSDARDHTRVDWKRPKYTS--------ALTYDGVKVMAEAFQSL--RRQRIDISRRGN--- 319
            ::.       |..:....|..:.        |||||.|:|:||..:.|  :.|.::.|.|.:
  Fly   281 EKL-------HQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQ 338

Mouse   320 -AGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWN 383
             .|....|          ..|:| :::.:.:||.:.| |...|..:|..|||::..|:.|:|.|.
  Fly   339 PDGSTFRN----------YMRSL-EIKEKTITGRIYF-EGNVRKGFTFDVIELQTSGLVKVGTWE 391

Mouse   384 EDDKF----VPAATDAQAGGDNSSVQNRTYIV-TTILEDPYVMLKKNANQFEGNDRYEGYCVELA 443
            |...|    .|.|.:.. ..|:.|:.|:|:|| .::...||..|.::.:...||::::||.|:|.
  Fly   392 EGKDFEFQRPPQAVNFN-DIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLI 455

Mouse   444 AEIAKHVGYSYRLEIVSDG--KYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFS 506
            .|:|..:|:::...   ||  .||:.:..|.:.:||:.|:|.||||:|:..||||..||||||||
  Fly   456 KELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFS 517

Mouse   507 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHS---- 567
            .|||:|||:|:..||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||.:
  Fly   518 IPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPC 582

Mouse   568 -EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYT 631
             ||.||        ..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||
  Fly   583 IEEPEE--------LENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYT 639

Mouse   632 ANLAAFLTVERMVSPIESAEDLA-KQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV 695
            ||||||||:|...|||.|.:||| .:.::.||....|||:.||..|:..::.||..|: :|.|.:
  Fly   640 ANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEM 703

Mouse   696 FVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPV 760
            .:...::|:.:| ||..|||:|:|||..|:...|: |:..|||..||.||||||..|....|:..
  Fly   704 LMENNQQGVDKV-KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKF 766

Mouse   761 NLAVLKLNEQGLLDKLKNKWWYD--KGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLV 823
            |.|:|:|.|||:|.:||||||.:  .|.|.:...|  |..|.|.:.|::|::.:|:.|..:::::
  Fly   767 NKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDD--DGPSELGVDNLSGIYVVLVIGSIISIII 829

Mouse   824 ALIEFCYKSRSESKRMK-GFCLIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKS 887
            :::.:||....::|..: .||....:.....||.|                 ||.|.:     ||
  Fly   830 SILCWCYFVYKKAKNYEVPFCDALAEEFRIVIRFS-----------------ENERPL-----KS 872

Mouse   888 MQSIPCMSHSSGMPL 902
            .|||...|.:|...:
  Fly   873 AQSIYSRSRNSSQSI 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	90/389 (23%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	176/391 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		4/23 (17%)
		PDZ-binding	904..907
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	89/385 (23%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	174/384 (45%)
		Lig_chan	547..819	CDD:459656	124/284 (44%)