Protein Alignment Gria1 and CG11155

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Alignment Length: 841
• Identity: 334/841 - (39%)
• Similarity: 486/841 - (57%)
• Gaps: 52/841 - (6%)

Mouse    16 VVGANFPNNIQIGGLF--PNQQSQEHAAFRFALSQLTEPPKLLP------QIDIVNISDSFEMTY 72
            |:....|..|::|.:|  ..::|...:||::|:.::.:...|||      .|:.|...|||..|.
  Fly    34 VISNALPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTK 98

Mouse    73 RFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVD-TSNQFVLQLRPE---LQEAL 133
            :.|||...||.||||..:....:.:.|.|.|..:..|.....:: .|.:|.:.|.|.   |..|.
  Fly    99 KVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINLYPSHTLLTLAY 163

Mouse   134 ISIIDHYKWQTFVYIYDADRGL-SVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKE 197
            ..|:.:..|.....||:.|.|| :::....:|.||       :.|...:.:.||.:.:.:.:|:.
  Fly   164 RDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAE-------MYIRQASPDSYRQVLRAIRQKEI 221

Mouse   198 RLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTI 262
            ..::||.....:.:....|::|:.|...|||:.........||..|:.:..|:|.|:||   |..
  Fly   222 YKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLV---DVD 283

Mouse   263 PARIMQQWRTSDARDHTRVDWKRP----KYTSALTYDGVKVMAEAFQSL---RRQRIDISRRGNA 320
            ..|.::.........|..:|....    :..|||.:|.|...|.....|   ..|...|......
  Fly   284 SKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQNFYIKNLSCT 348

Mouse   321 GDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNED 385
            .|      ..|..||.:...:.....:||||.|||.| |||..:.|.::::|.:.|:|:|||:.|
  Fly   349 SD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQEKIQKVGYWHPD 406

Mouse   386 DKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHV 450
            |..  ..:|..|..| |::.|.|.:|.|..|.||||:|::.| ..||.|:||:|::|...||..|
  Fly   407 DGV--NISDPTAFYD-SNIANITLVVMTREERPYVMVKEDKN-LTGNLRFEGFCIDLLKAIATQV 467

Mouse   451 GYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGIS 515
            |:.|::|:|.|..||...|:|.:|||:|.||:..|||:|||.:||...||.||||:||||:|||.
  Fly   468 GFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIG 532

Mouse   516 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEE--FEEGRDQTT 578
            |:.|.|......:|||::|||.|||:.::.|||.||..||:::|||||||.:..  ::|     |
  Fly   533 ILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKE-----T 592

Mouse   579 SDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 643
            ....|:|.|.||.||..|.|::||..::|::.|.|||||.|:||.||||||||||||||||||||
  Fly   593 DIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERM 657

Mouse   644 VSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVR 708
            :||||||.|||:||||:|||||.|||..|||.|||.:::|||.||::.:.:|||:|.|:|:.||
  Fly   658 ISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRV- 721

Mouse   709 KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLL 773
             .:|.||:|:||||.:|..|| .|:..::||.||||||||||||||..|:.::||:|:|.|:|::
  Fly   722 -MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGII 784

Mouse   774 DKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSR 833
            ..|.:|||.:.|: |.......:.|.:||.:.|:.|||.:|:.||.||::||:.|||:.||
  Fly   785 QILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSR 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	101/385 (26%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	206/383 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	101/387 (26%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	204/377 (54%)
		Lig_chan	554..828	CDD:459656	149/281 (53%)