Protein Alignment Gria1 and Ekar

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Alignment Length: 886
• Identity: 319/886 - (36%)
• Similarity: 487/886 - (54%)
• Gaps: 84/886 - (9%)

Mouse    18 GANFPNNIQIGGLFPNQQSQEHA--AFRFALSQLTEPPKLLPQ------IDIVNISDSFEMTYRF 74
            |...|..::||.:|.||....::  |||:|:.:|.....|||:      ::.||..||||...:.
  Fly    16 GLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKV 80

Mouse    75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQ---EALISI 136
            |.....||.|:|...:......:.|.|.||.:..|..|     ::.|.:.:.|..|   .|...:
  Fly    81 CKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINVYPSKQLVNYAFNDV 140

Mouse   137 IDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVV 201
            |.:..|..|..:::.:.|:..|.::..:...:      |::...:.:.|.....:.:.|:...::
  Fly   141 IQYLNWTRFGILHEKENGIINLHQLSRSFHGE------VHMRQVSRDSYVSALNEFKGKEIHNII 199

Mouse   202 VDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARI 266
            :|..|..::.:|..|::.:.|...|||:..:......||..||.:..|:|.|:||:..|....:|
  Fly   200 IDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQI 264

Mouse   267 MQQWRTSDARDHTRVDWKRP-------KYT-----SALTYDGVKVMAEAFQSLRRQR----IDIS 315
            ::     |...::...:|:|       |.|     .||.:|.|.|.|...|:|.:..    ::||
  Fly   265 LK-----DIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS 324

Mouse   316 RRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380
                   |....:  |..|:.:...|..|.::||||.:||.: |:|..:.|.:|::|...|.|:|
  Fly   325 -------CEEENS--WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVG 379

Mouse   381 YW--------NEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEG 437
            .|        .|...|..|.:           .|.|.:|.||||.||||:....| |.||:|:.|
  Fly   380 EWTPHGHLNITEPSMFFDAGS-----------MNVTLVVITILETPYVMMHYGKN-FTGNERFYG 432

Mouse   438 YCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEV 502
            :||::...|::.||:.|.|::|.|.||||:||:|..|||||.:|:..:||:||..:|||..||.|
  Fly   433 FCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESV 497

Mouse   503 IDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHS 567
            |||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.||.||
  Fly   498 IDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW-- 560

Mouse   568 EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 632
             :.....|.......|:|.:.:|.||::|.||||..||.||::|.||:...|.||:|||::||||
  Fly   561 -KCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624

Mouse   633 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFV 697
            |||||||.|||::|||:|||||.||||:||||::|||..|||.|.|..::|:|..|.:.:||.|.
  Fly   625 NLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFT 689

Mouse   698 RTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNL 762
            .|.|:|:.||  ::|.||:|:||||.:||.|| .|:..::||.||:|||||||||||..|:.::|
  Fly   690 TTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISL 751

Mouse   763 AVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALI 826
            |:|:|.|:|.:..|.:|||.:..| |.......:.|.::|.|.::.|||.:||.|:.:|.:||..
  Fly   752 AILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFF 816

Mouse   827 EFCYKSRSESKRMKGFCLI----PQQSINEAIRTSTLPRNS 863
            ||.|..|...:......::    .|..|.|:.|..|.|..|
  Fly   817 EFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRS 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	98/400 (25%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	194/381 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		3/7 (43%)
		PDZ-binding	904..907
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	96/391 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	192/375 (51%)
		Lig_chan	532..806	CDD:459656	134/279 (48%)