Protein Alignment Gria1 and Ir93a

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_650924.3
• Gene: Ir93a / 42471
• FlyBaseID: FBgn0259215
• Length: 868
• Species: Drosophila melanogaster
• Alignment Length: 888
• Identity: 167/888 - (18%)
• Similarity: 314/888 - (35%)
• Gaps: 236/888 - (26%)

Mouse    88 FYERRTVNMLTSFCGALHV--CFITPSFPVDTSNQFVLQL--------RPELQEALISIIDHYKW 142
            ::....|.:...|..|:.|  |..|.:|..:|....:|.:        |..|..||:..|
  Fly    82 YFSWNAVRLKKDFLAAITVTDCENTWNFYKNTQETSILLIAITDSDCPRLPLNRALMVPI----- 141

Mouse   143 QTFVYIYDADRGLSVLQRVLDTAAEK--NWQVTAVNILTTTEEGYRMLFQDL------------- 192
                    .:.|....|.:||...::  ||:...|.:..|..|...:|.:.:
  Fly   142 --------VENGDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVKSIVHESITNHITPIS 198

Mouse   193 -------------------------------EKKKERLVVVDCESERLNAILGQIVKLEKNGIGY 226
                                           |:.:::.:|:....|       .|:::.:....:
  Fly   199 LILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHE-------DIIEIAETLNMF 256

Mouse   227 H-------YIL------ANLGFMDIDLNKFKESGANVT---------------------GFQLVN 257
            |       ::|      .:.|.:.|:|    :.|||:.                     ...|||
  Fly   257 HVGNQWMIFVLDMVARDFDAGTVTINL----DEGANIAFALNETDPNCQDSLNCTISEISLALVN 317

Mouse   258 YTDTIPARIMQQWRTSDARDHTRVDW------KRPKYTSALTY--DGVKVMAEAFQSLRRQRIDI 314
            ....|  .:.::....:..|.   :|      |:.|....|.|  :.:|..|:. .|..|.|::
  Fly   318 AISKI--TVEEESIYGEISDE---EWEAIRFTKQEKQAEILEYMKEFLKTNAKC-SSCARWRVE- 375

Mouse   315 SRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRT------NYTLHVIEMKH 373
                        .|:.||:.                   |.|.|.|.|      |.....|
  Fly   376 ------------TAITWGKS-------------------QENRKFRSTPQRDAKNRNFEFI---- 405

Mouse   374 DGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGY 438
                .||||.....||  ..:..........:|.|..:.|:...|:.:|.||:|..  ...::|.
  Fly   406 ----NIGYWTPVLGFV--CQELAFPHIEHHFRNITMDILTVHNPPWQILTKNSNGV--IVEHKGI 462

Mouse   439 CVELAAEIAKHVGYSYRLEIVSDGK--------YGARDPDTKAWNGMVG-----------ELVYG 484
            .:|:..|:::.:.:||.|...|..|        .|..:.|.     :||           |:|.|
  Fly   463 VMEIVKELSRALNFSYYLHEASAWKEEDSLSTSAGGNESDE-----LVGSMTFRIPYRVVEMVQG 522

Mouse   485 -RADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 548
             :..:|....|:....::..::::|......|.:.:||.:.. .::.|..|...|.|.|::...:
  Fly   523 NQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKPDEVS-RIYLFTAPFTVETWFCLMGIIL 586

Mouse   549 GVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGR 613
            ..:..|:.::|.:|       .:|.|....|...:.|      |:..||.:|||....|.:.|||
  Fly   587 LTAPTLYAINRLAP-------LKEMRIVGLSTVKSCF------WYIFGALLQQGGMYLPTADSGR 638

Mouse   614 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRR-SK 677
            :|.|.||...::::::|..||.||||..:....::....|....:|....|..|:   ||.| .:
  Fly   639 LVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDHKDIVQYGLRNGT---FFERYVQ 700

Mouse   678 IAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKG---KYAYLLESTMNEYIEQRKPCDTMKVGG 739
            ....|....|::.|:  ::....||.:..|::.:.   .:...|:..:..:.|:.|.|.......
  Fly   701 STTREDFKHYLERAK--IYGSAQEEDIEAVKRGERINIDWRINLQLIVQRHFEREKECHFALGRE 763

Mouse   740 NLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWY-----DKGECGSGGGDSKDKTS 799
            :...:...:..|..||..:.||..:..:...|.:::     |:     ..|:|.......:....
  Fly   764 SFVDEQIAMIVPAQSAYLHLVNRHIKSMFRMGFIER-----WHQMNLPSAGKCNGKSAQRQVTNH 823

Mouse   800 ALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGF 842
            .:::.::.|.|.:|:.|..||:|:...||.|:....|::.:.|
  Fly   824 KVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFRASRKRRQF 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	67/407 (16%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	87/409 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:473866	68/291 (23%)
		Lig_chan	574..836	CDD:459656	59/284 (21%)