Protein Alignment Gria1 and Ir84a

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_649720.2
• Gene: Ir84a / 40891
• FlyBaseID: FBgn0037501
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 623
• Identity: 140/623 - (22%)
• Similarity: 244/623 - (39%)
• Gaps: 146/623 - (23%)

Mouse   280 RVDWKRPK----------YTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPW--- 331
            ||.:.||:          |.|..|  .|.|:......:|||...::  ..||  ..|.::.|
  Fly    75 RVQFYRPEMSANFEDLMFYGSPRT--AVLVLNSEHVLVRRQVFGVA--SEAG--YFNNSLAWFIL 133

Mouse   332 GQG---IDIQRALQQV----RFEGLTGNVQFNEKG---------------RRTNYTLHVIEMKHD 374
            |.|   :.:::.:.|:    |. |:..::....:|               |:.|..| :||.|
  Fly   134 GSGRESLPVEQLIDQLLSGYRM-GIDADITVALRGPDNASMLFYDVYRISRQANTPL-IIEKK-- 194

Mouse   375 GIRKIGYWNEDDKFVPAATDAQAGGD--NSSVQNR------TYIVTTIL-EDP-------YVMLK 423
                 |.|.....:       |..|:  |:.|..|      |.|.:|:| |.|       |:...
  Fly   195 -----GLWTHSGGY-------QKFGNFKNTWVIRRRNFLNVTLIGSTVLTEKPPGFGDMEYLADD 247

Mouse   424 KNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADV 488
            |...|.:...|......:|...:     ::..|.|....|:|.. .|..:|:|::|::....||.
  Fly   248 KQLQQLDPMQRKTYQLFQLVERM-----FNLSLAISLTDKWGEL-LDNGSWSGVMGQVTSREADF 306

Mouse   489 AVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV 553
            ||.|:...|.|:..:.:|....:..|..:.:.|::|..... |.:||:.::|.|::....|.:::
  Fly   307 AVCPIRFVLDRQPYVQYSAVLHTQNIHFLFRHPRRSHIKNI-FFEPLSNQVWWCVLALVTGSTIL 370

Mouse   554 LFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFS-LGAFMQQGCDISP-----RSLSG 612
            |.              |....::..|:..|.|..   :||: |..::|||    |     |..|.
  Fly   371 LL--------------FHVRLERMLSNMENRFSF---VWFTMLETYLQQG----PANEIFRLFST 414

Mouse   613 RIVGGVWWFFTLIIISSYTANLAAFLTVE--RMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRR 675
            |::..:...|:.:::..|.|.:...|..|  |.:..:::..|    :.:|.|..........|..
  Fly   415 RLLISLSCIFSFMLMQFYGAFIVGSLLSESARSIVNLQALYD----SNLAIGMENISYNFPIFTN 475

Mouse   676 SKIAVFEKMWT--YMKSAEPSVFVRTTEEGMIRVRKSKGKYAY----------LLESTMNEYIEQ 728
            :...:...::.  ..||.|.::.  :.::|..|:  .:|::|:          |||..|:|
  Fly   476 TSNQLVRDVYVKKICKSGEHNIM--SLQQGAERI--IQGRFAFHTAIDRMYRLLLELQMDE---- 532

Mouse   729 RKPCDTMKVGGNL--DSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGG 791
            .:.||..:|..||  ||   |...||||..|..:..|:|.....|||.....||...:.:|
  Fly   533 AEFCDLQEVMFNLPYDS---GSVMPKGSPWREHLAHALLHFRATGLLQYNDKKWMVRRPDC---- 590

Mouse   792 GDSKDKTS--ALSLSNVAGVFYILIGGLGLAMLVALIE 827
              |..|||  .:.|.:.|...:.|...:..:.||.|:|
  Fly   591 --SLFKTSQAEVDLEHFAPALFALALAMVASALVFLLE 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	30/146 (21%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	94/416 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir84a	NP_649720.2	ATP-sulfurylase	<54..>112	CDD:460310	9/38 (24%)
		Periplasmic_Binding_Protein_Type_2	<282..>355	CDD:473866	20/74 (27%)
		Lig_chan	353..602	CDD:459656	65/290 (22%)