Protein Alignment Gria1 and Ir75a

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 472
• Identity: 96/472 - (20%)
• Similarity: 186/472 - (39%)
• Gaps: 82/472 - (17%)

Mouse   402 SSVQNRT-------------YIVTTILEDPYVMLKKNANQF--EGNDRYEGYCVELAAEIAKHVG 451
            ||:|.|:             .:.|.:.:.|..:......:|  :.||.:    ::..|....|:.
  Fly   187 SSLQKRSKYGNREQLTDVVLRVATVVTQRPLTLSDDELIRFLSQENDTH----IDSLARFGFHLT 247

Mouse   452 YSYRLEIVSDGKYGARDPDTKAWN------GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFM 510
            ...|..:....|:...|    :|:      |.||.:|...||:...|   :|..|..:.:....:
  Fly   248 LILRDLLHCKMKFIFSD----SWSKSDVVGGSVGAVVDQTADLTATP---SLATEGRLKYLSAII 305

Mouse   511 SLGI--SIMI-KKPQKSKPGVFSFLDPLAYEIWMCI--VFAYIGVS--VVLFLVSRFSPYEWHSE 568
            ..|.  |:.| :.|..:......||.|.:..:|...  |.:.|||.  :..::..:.....|..:
  Fly   306 ETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVWYLFGGVLSLIGVLLWITFYMECKRMQKRWRLD 370

Mouse   569 EFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTAN 633
            ...              .:.::...|.||...|...:.|||..||::     :|.|.:||....|
  Fly   371 YLP--------------SLLSTFLISFGAACIQSSSLIPRSAGGRLI-----YFALFLISFIMYN 416

Mouse   634 LAAFLTVERMV-SPIESAEDLAKQTEIAYGTLEAG-----STKEFFRRSK---IAVFEKMWTYMK 689
            ....:.|..:: ||::|  .:....::|..:|..|     .||.:...|:   |.:|.|.....:
  Fly   417 YYTSVVVSSLLSSPVKS--KIKTMRQLAESSLTVGLEPLPFTKSYLNYSRLPEIHLFIKRKIESQ 479

Mouse   690 SAEPSVFVRTTEEGMIRVRKSKGKYAYLLEST-----MNEYIEQRKPCDTMKVGGNLDSKGYGIA 749
            :..|.::: ..|:|::|||.:.| |.|:.|::     :..|...::.||..:|....:...| ..
  Fly   480 TQNPELWL-PAEQGVLRVRDNPG-YVYVFETSSGYAYVERYFTAQEICDLNEVLFRPEQLFY-TH 541

Mouse   750 TPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILI 814
            ..:.|..:....|..|::.|.|:..|.::.|.:.|..|     .:::....:.:..||.:..:||
  Fly   542 LHRNSTYKELFRLRFLRILETGVYRKQRSYWVHMKLHC-----VAQNFVITVGMEYVAPLLLMLI 601

Mouse   815 GGLGLAMLVALIEFCYK 831
            ....|.:::.|:|..:|
  Fly   602 CADILVVVILLVELAWK 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	84/422 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	27/119 (23%)