Protein Alignment Gria1 and Ir68b

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_648548.1
• Gene: Ir68b / 39378
• FlyBaseID: FBgn0036250
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 753
• Identity: 125/753 - (16%)
• Similarity: 228/753 - (30%)
• Gaps: 248/753 - (32%)

Mouse   165 AAEKNWQVT----AVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIG 225
            |.|:|.|||    ..:...:.:..|..|..||.:         |...||..|...:...|
  Fly    27 AVEQNVQVTYLYRCASCPASFDADYSALELDLYR---------CVGSRLPVITRNMEAHE----- 77

Mouse   226 YHYILANLGFMDIDLNKFKESGANVTGFQL--VNYTDTIPARIMQQWRTSDARDHTRVDWKRPKY 288
                          |..|:.:. :::.||:  ....|::..||:........|.|..      ||
  Fly    78 --------------LEPFRRTD-SLSIFQIPAAEKGDSLVRRILDMLNPHQRRKHMH------KY 121

Mouse   289 TSALTYDGVKVMAEAFQSLRRQRI--DISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTG 351
            .......|...:...|:....:::  .::..|............||....|||         |.|
  Fly   122 LFVWPNAGRHQLLRLFRGSWAKKLLYGLAITGRENGTFDFDPFAWGGLQVIQR---------LDG 177

Mouse   352 NVQFNEKG--------RRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGD--NSSVQN 406
            .|.:..|.        |.:.:|..::.|....:...||...|      ...|:..|:  |:||
  Fly   178 EVPYARKVKDLRGYPLRFSMFTDPLMAMPRSPVETAGYQAVD------GVAARVVGEMLNASV-- 234

Mouse   407 RTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDT 471
             ||:..                 |.|:.| |.|                   :.:|.|
  Fly   235 -TYVFP-----------------EDNESY-GRC-------------------LPNGNY------- 254

Mouse   472 KAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKS-KPGVFSFLDPL 535
               .|:|.::|.|....|.....:.......::...|:....:.:::  |..: :|....|:...
  Fly   255 ---TGVVSDIVGGHTHFAPNSRFVLDCIWPAVEVLYPYTRRNLHLVV--PASAIQPEYLIFVRVF 314

Mouse   536 AYEIWMCIVFAYIGVSVVLFLVSRFS-----------PYEWHSEEFEEGRDQTTSDQSNEFGIFN 589
            ...:|..::...:.|.:|.:::.|..           ...|: |..|........:.:.....|:
  Fly   315 RRTVWYLLLVTLLVVVLVFWVMQRLQRRIPRRGVIQFQATWY-EILEMFGKTHVGEPAGRLSSFS 378

Mouse   590 SL-WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL 653
            |: .|.:|                      |..|:.::.:.|.|.|.:..........::..:||
  Fly   379 SMRTFLMG----------------------WILFSYVLSTIYFAKLESGFVRPSYEEQVDRVDDL 421

Mouse   654 ------------------AKQTEIAYGTLEAGS--------------------------TKEFFR 674
                              :..||..||.||..|                          .::|..
  Fly   422 VHLDVHIYAVTTMYDAVRSALTEHQYGLLENRSRQLPLGIATSYYQPVVRRRDRRAAFIMRDFHA 486

Mouse   675 RSKIAVFEKMWTYMKSAEPSVF--VRTTEEGMI--RVRKSKGKYAYLLESTMNEYIEQ------R 729
            |..:|:     ||...||...:  .|.....||  .:......:.:.|||..:.::|.      |
  Fly   487 RDFLAI-----TYDSQAERPAYHIAREYLRSMICTYILPRGSPFLHRLESLYSGFLEHGFFEHWR 546

Mouse   730 KPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD- 793
            :.....:||.:.|::.:                    |.:.|           |:.:..||..:
  Fly   547 QMDLITRVGASPDAEEF--------------------LEDLG-----------DQTDTDSGSNEL 580

Mouse   794 -SKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830
             .::|...|:|..:.|.||:...|:|::.|...:|..:
  Fly   581 AIRNKKVVLTLDILQGAFYLWSVGIGISCLGFAVEHAH 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	44/242 (18%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	64/447 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir68b	NP_648548.1	None