Protein Alignment Gria1 and Ir68a

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_648455.2
• Gene: Ir68a / 39269
• FlyBaseID: FBgn0036150
• Length: 704
• Species: Drosophila melanogaster
• Alignment Length: 822
• Identity: 152/822 - (18%)
• Similarity: 280/822 - (34%)
• Gaps: 254/822 - (30%)

Mouse   104 LHVCFIT----PSFPVDTSNQ-----FVLQLRPELQEALISIIDHYKW-----QTFVYIYDADRG 154
            |.|.||:    .|.|:..:|.     :.:||:..||:.|        |     :.|..|.| |..
  Fly     7 LIVAFISLAMATSIPIPIANPAPLSGYEMQLKILLQKIL--------WVANVKRCFAVITD-DLH 62

Mouse   155 LSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVV-------DCESERLNAI 212
            ..:..|:...:..:  :|....::.|.|.      .||::...::.:.       |||...:..:
  Fly    63 YPIYDRIFFESVGR--RVIPFFVMRTNES------DDLQRPSRQVELFVKAIKSSDCELNVITIL 119

Mouse   213 LG-QIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRT-SDA 275
            .| |:.:.    :||.|       .:..||..|:       |.|::......:.::..|.. .||
  Fly   120 NGWQVQRF----LGYIY-------DNRSLNMQKK-------FVLLHDLRLFESDMIHLWSVFIDA 166

Mouse   276 RDHTRVDWKRP---KYT-SALTY----DGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWG 332
                 :..||.   ||| |.:.:    .||.||..                     :||    |.
  Fly   167 -----IFLKRQLDNKYTISTIAFPGILSGVLVMKN---------------------IAN----WE 201

Mouse   333 QGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQA 397
            .|            :||.|.:.|
  Fly   202 LG------------KGLNGRILF------------------------------------------ 212

Mouse   398 GGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYS---YR---- 455
             .|.:|....|.:...|.|...::|..||.:     .::|..||:...:.|.:.:.   |:
  Fly   213 -ADKTSNLFGTSLPVAISEHVPMVLWANATK-----SFQGVEVEIMNALGKALNFKPVYYKPNQT 271

Mouse   456 -------LEIVSDGKYGARDPDTKAWNG------MVGELVYGRADVAVAPLTITLVREEVIDFSK 507
                   |:..:...||:.:||..|.||      :|.|:....|..|:..|.:..|..::::.|.
  Fly   272 ENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSA 336

Mouse   508 PFMSLGISIMIKKPQKSKPGVF-SFLDPLAYEIWMCIVFAYIGVSVVLFLVS------------- 558
            |.....::.:  .|:.|....: :|:.|.:..:|:.::.:...|..|.:.:|
  Fly   337 PHNFECLTFL--TPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSE 399

Mouse   559 -----------RFSPYEWHSEEFEEGRDQTTSDQSNEF------GIFNSLWFSLGAFMQQGCDIS 606
                       ...|..:....|.....:..|.:.:..      |..|.:..:....:.......
  Fly   400 FFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALPRM 464

Mouse   607 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGST-- 669
            ||:...|::.|.:|.:.::::::|.|:..|.|........|::.|||.: :.|...|   |:|
  Fly   465 PRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR-SHIPPST---GATEN 525

Mouse   670 KEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDT 734
            ::||..:...|..|:...|:     ||..:.:   :..|.:||:.||........|:..
  Fly   526 RQFFLEANDEVARKVGEKME-----VFGYSDD---LTSRIAKGQCAYYDNEFYLRYLRV------ 576

Mouse   735 MKVGGNLDSKGYG--------------IATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKG 785
                  .|..|..              :|..|.|||:..|:.::..|.|.||:    .||..|..
  Fly   577 ------ADESGSALHIMKECVLYMPVVLAMEKNSALKPRVDASIQHLAEGGLI----AKWLKDAI 631

Mouse   786 ECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIE 827
            |.......::.: :.:::......|..|:.|..::||..|.|
  Fly   632 EHLPAEALAQQE-ALMNIQKFWSSFVALLIGYVISMLTLLAE 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	57/318 (18%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	85/447 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir68a	NP_648455.2	Lig_chan	367..661	CDD:459656	57/322 (18%)