Protein Alignment Gria1 and GluRIA

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 972
• Identity: 382/972 - (39%)
• Similarity: 551/972 - (56%)
• Gaps: 133/972 - (13%)

Mouse    25 IQIGGLFPNQQSQEHAAFRFA-----LSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYA 84
            |.:|.:|........:||::|     |:..:...:|...:|::|.:|:|:::...|:|||:|||:
  Fly    40 IPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTADAFKLSRLICNQFSRGVYS 104

Mouse    85 IFGFYERRTVNMLTSFCGALHVCFITPSFP----VDTSN--QFVLQLRPELQEALISIIDHYKWQ 143
            :.|.....:.:.|.|:.....:.|:||.||    ..:|.  .|.:.:||:..:|:|..|.:|.||
  Fly   105 MLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAISMRPDYHQAIIDTIQYYGWQ 169

Mouse   144 TFVYIYDADRGLSVLQRVLDTAAEKN--WQVTAVNILTTTEEGYRML--FQDLEKKKERLVVVDC 204
            :.:|:||:..||..||::.......|  ::|..|..:.........|  .:||.:..::.:|:||
  Fly   170 SIIYLYDSHDGLLRLQQIYQELKPGNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSKKRIVLDC 234

Mouse   205 ESERLNAILGQIVKLEKNG-IGYHYILANLGFMD----IDLNKFKESGA-NVTGFQLVNYTDTIP 263
            .:|....|:.|.|:..|.| ..|||:|:.| .||    .|:.:|   || |:|||::|:..
  Fly   235 PAEMAKEIIVQHVRDIKLGRRTYHYLLSGL-VMDNHWPSDVVEF---GAINITGFRIVDSN---- 291

Mouse   264 ARIMQQWRTSDARDHTRVDWKRPKYT-------------SALTYDGVKVMAEAFQSLRRQRID-- 313
            .|.::.:.  |:|.......:.....             :||.||.|.|:.|||..:.|::.|
  Fly   292 RRAVRDFH--DSRKRLEPSGQSQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQF 354

Mouse   314 ----ISRRGNAG----------------DCLANP--AVPWGQGIDIQRALQQVRFEGLTGNVQFN 356
                :.||.:.|                ||..:.  ..||.||..|.|.|::|..:||:|.::|:
  Fly   355 RSNHLQRRSHGGSSSSSATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGEIRFD 419

Mouse   357 EKGRRTNYTLHVIEMK-HDGIRKIGYWNEDDKFVPAATDAQAGGDNSSV-------QNRTYIVTT 413
            |.|||.||||||:||. :..::::..|.:|...:|..:...|....|:.       :|.||||::
  Fly   420 EDGRRINYTLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYDRNHTYIVSS 484

Mouse   414 ILEDPYVMLKK--NANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTK-AWN 475
            :||:||:.||:  ......||||:||||.:||..:|..:|..|.:.:|.||.|||.:.... .|:
  Fly   485 LLEEPYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWD 549

Mouse   476 GMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW 540
            ||||||:...||:|::.:|||..||.|||||||||:||||||||||.|..|||||||:||:.|||
  Fly   550 GMVGELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIW 614

Mouse   541 MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQ---------------------SNE 584
            :.::.:|:|||.||:.|:||.||||..  ....:..:|:.|                     .||
  Fly   615 ISVILSYVGVSFVLYFVTRFPPYEWRI--VRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNE 677

Mouse   585 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 649
            |.:.||.|:||.|||||||||:|.|::|||...||||||:|:||||||||||||||||||:||::
  Fly   678 FTMLNSFWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKT 742

Mouse   650 AEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKY 714
            .|||..||::.||||..|||.||||||:|.:..|||.|| :|.....|.|.:||:.|||:|||||
  Fly   743 PEDLTMQTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYM-NANQHHSVHTYDEGIRRVRQSKGKY 806

Mouse   715 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNK 779
            |.|:||..|||:..|.||||||||.|:|:||:|:|||.||.||..:|.|||.|.|.|.|.:::||
  Fly   807 ALLVESPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNK 871

Mouse   780 WWYDKGECGSGGGDSKDKT-SALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFC 843
            ||:||.||..   |.:..| :.||||||||::|||||||.||::||::||             ||
  Fly   872 WWFDKTECNL---DQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF-------------FC 920

Mouse   844 LIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGAT 905
                       |..| |:....|::|.:| |..|.:.|..:.:...|...|...:.:.:.|:
  Fly   921 -----------RNKT-PQLKSPGSNGSAG-GVPGMLASSTYQRDSLSDAIMHSQAKLAMQAS 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	120/424 (28%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	220/404 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		7/23 (30%)
		PDZ-binding	904..907		1/2 (50%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	120/424 (28%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	220/404 (54%)
		Lig_chan	610..906	CDD:459656	162/301 (54%)