DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gria1 and Ir64a

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_647962.1	Gene:	Ir64a / 38616	FlyBaseID:	FBgn0035604	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	116/645 - (17%)
Similarity:	215/645 - (33%)	Gaps:	206/645 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse   326 NPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVP 390
            ||.:.:|..:::.........||    :|.:...|.|:.....::|:|..:|          .:.
  Fly   266 NPGLNYGGHVNLTEIGSFTPTEG----IQLHTWFRTTSTVRRRMDMQHARVR----------CMV 316

Mouse   391 AATDAQAGGDNSSVQNRT-----YIVTTILEDPYVMLKKNANQFEG-NDRYEGYCVELAAEIAKH 449
            ..|:          :|.|     |:..|:......|.:.|.|.... .|.:....|     :::.
  Fly   317 VVTN----------KNMTGTLMYYLTHTMSGHIDTMNRFNFNLLMAVRDMFNWTFV-----LSRT 366

Mouse   450 VGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGI 514
            ..:.|    |.:|::          :||:|.|:....|:..||:...|.|.:.||.:....|...
  Fly   367 TSWGY----VKNGRF----------DGMIGALIRNETDIGGAPIFYWLERHKWIDVAGRSWSSRP 417

Mouse   515 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVV-LFLVSRFSPYEWH------------ 566
            ..:.:.|:.::.....||.|...::|:.||    |..|: :|::...:..||.
  Fly   418 CFIFRHPRSTQKDRIVFLQPFTNDVWILIV----GCGVLTVFILWFLTTIEWKLVPHDGSALIKP 478

Mouse   567 --------------------------------------SEEFEEGRDQTTSD----------QSN 583
                                                  .|:.||..|.|..|          :.|
  Fly   479 KGGAPPRHHYQQQQQQEQVEAPVRPITAVSVVVSKEKVEEKQEEYEDSTPIDAGTLWQRCYQKLN 543

Mouse   584 EF---------------GIF-NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 632
            ::               |:| .|:.|.:|...|||...|...:|||.:......|:..|...|:|
  Fly   544 KYIKDRKAKQKKAPERVGLFLESVLFFVGIICQQGLGFSTSFVSGRCIVITSLLFSFCIYQFYSA 608

Mouse   633 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGS-----TKEFFRRSKIAVFEKMWTYMK--- 689
            ::...|.:|: ...|::..||      .:.:|:.|.     .:::|..:|..|  .|..|.|
  Fly   609 SIVGTLLMEK-PKTIKTLSDL------VHSSLKVGMEDILYNRDYFLHTKDPV--SMELYAKKIT 664

Mouse   690 ---------------------SAEPSVFVR---------------------TTEEGMIRVRKSKG 712
                                 |.:|:...|                     ..|.|::|   ..|
  Fly   665 SVPTTKENEADEDEPVDPNPVSTDPAKSYRDIVHSHETGAHAKDNAASNWLDPETGLLR---HLG 726

Mouse   713 KYAYLLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGV 772
             :|:.::     ..:.|...::..||..:|......|...| ..|.|.:|..::..:.:::|.|:
  Fly   727 -FAFHVDVAAAYKIIAETFSEQDICDLTEVSMFPPQKTVSI-MQKNSPMRKVISYGLRRVTETGI 789

Mouse   773 LDKLKSKWWYDKGECGSKDSGSKDKTSAL--SLSNVAGVFYILIGGLGLAMLVALIEFCY 830
            |....:.|...|..|     ..|.:||.|  .:..|:....||:....:.:::...|..|
  Fly   790 LTYHFNVWHSRKPPC-----VKKIETSDLHVDMDTVSSALLILLFSYAITLMILGTEILY 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_001106796.1	PBP1_iGluR_AMPA_GluR1	26..389	CDD:107385	11/62 (18%)
		ANF_receptor	37..372	CDD:279440	8/45 (18%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	94/518 (18%)
		Glutamate binding. /evidence=ECO:0000250	492..494		1/1 (100%)
		Lig_chan	538..817	CDD:278489	74/412 (18%)
		Glutamate binding. /evidence=ECO:0000250	668..669		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir64a	NP_647962.1	Periplasmic_Binding_Protein_Type_2	351..>465	CDD:304360	27/136 (20%)
Ir64a	NP_647962.1	Lig_chan	563..828	CDD:278489	57/283 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840