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Protein Alignment Gria1 and clumsy

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	313/962 - (32%)
Similarity:	488/962 - (50%)	Gaps:	98/962 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 IFAFFCTGFL--GAVVGANFP-NNIQIGGLFPNQQSQEHAAFRFALSQ---LTEPPKLLPQIDIV 62
            :::.|.|.||  ...|.|:.. :...:|.:|.:.:.:...|||.|:.:   |....:|:|.:...
  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYA 65

Mouse    63 NISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFI------TPSFPVDTSNQF 121
            |..|||.|....|:..|:||.||||.....:.:::.|.|..|.:..|      ..|.|....:..
  Fly    66 NTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTM 130

Mouse   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEE 183
            .|.:.|:   |.:.|..|:..:.|::|..:|:.|:.|..||.:|. ..|.....|.|..|...::
  Fly   131 TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQ-VGEPISNPTTVKQLGPGDD 194

Mouse   184 GYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248
             :|...::::...:..:::.|..:.|..||.|..:|:..|......:..|....||..:.....|
  Fly   195 -HRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEA 258

Mouse   249 NVTGFQLVNYTDTIPARIMQQWRTSDARD--HTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQR 311
            |:|..:|::.:|.....::..|...:.|:  :.:||..|.|....|..|.|.:.::....|
  Fly   259 NITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL---- 319

Mouse   312 IDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGI 376
             .|.....|.|.......||..|..|...::....|..||.:.|||.|:|:.:||..:|:..||.
  Fly   320 -GIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGF 383

Mouse   377 RKIGYW---------NEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLK--KNANQFE 430
            ..:..|         |:|::     ::.:.|   ..:.|:|:||::.|..|::.|:  :......
  Fly   384 LDLATWDPVNGLDVLNDDEE-----SEKRVG---QKLSNKTFIVSSRLGAPFLTLREPQEGEILT 440

Mouse   431 GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTI 495
            ||.|||||.::|..||||.:.:.:...:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:
  Fly   441 GNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTM 505

Mouse   496 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 560
            |..|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.
  Fly   506 TSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARM 570

Mouse   561 SPYEWHS-------EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 618
            :|.:|.:       ||.|           |.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:
  Fly   571 APDDWENPHPCKEPEEVE-----------NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGM 624

Mouse   619 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEK 683
            ||||.|::::|||||||||||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.::|
  Fly   625 WWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQK 689

Mouse   684 MWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 748
            |||.|:||.||||.:|.:||:.||:|.|..||:|:|||..||..:|| ||.:::||.||.|.|||
  Fly   690 MWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGI 753

Mouse   749 ATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWW---YDKGECGSKDSGSKDKTSALSLSNVAGVF 810
            |.|..|..|..::.|||||.|.|.|.:||.|||   :..|.|...|....| |..|.|.||.|||
  Fly   754 AMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVF 817

Mouse   811 YILIGGLGL--AMLVALIEFCYKSRSESKRMKGFCLIPQQSINEA------------IRTSTLPR 861
            .:|  ||||  ||::...||.:       .:|...:..:.|:.||            |.|..:..
  Fly   818 LVL--GLGLLSAMVLGCTEFLW-------NVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHT 873

Mouse   862 NSGAGASGGSGSGEN-------GRVVSQDFPKS--MQSIPCMSHSSGMPLGA 904
            :|.:|:|..|.|..:       .:.:|....||  .|.:....||....:|:
  Fly   874 SSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGS 925

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.