Protein Alignment: Gria1 and clumsy

• Sequence 1: NP_001106796.1
• Gene: Gria1
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_001036373.1
• Gene: clumsy
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Alignment Length: 962
• Identity: 313/963 (33%)
• Similarity: 488/963 (51%)
• Gaps: 98/963 (10%)

Mouse     4 IFAFFCTGFL--GAVVGANFP-NNIQIGGLFPNQQSQEHAAFRFALSQ---LTEPPKLLPQIDIV 62
            :::.|.|.||  ...|.|:.. :...:|.:|.:.:.:...|||.|:.:   |....:|:|.:...
  Fly     1 MYSLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYA 65

Mouse    63 NISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFI------TPSFPVDTSNQF 121
            |..|||.|....|:..|:||.||||.....:.:::.|.|..|.:..|      ..|.|....:..
  Fly    66 NTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTM 130

Mouse   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEE 183
            .|.:.|:   |.:.|..|:..:.|::|..:|:.|:.|..||.:|. ..|.....|.|..|...::
  Fly   131 TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQ-VGEPISNPTTVKQLGPGDD 194

Mouse   184 GYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248
             :|...::::...:..:::.|..:.|..||.|..:|:..|......:..|....||..:.....|
  Fly   195 -HRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEA 258

Mouse   249 NVTGFQLVNYTDTIPARIMQQWRTSDARD--HTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQR 311
            |:|..:|::.:|.....::..|...:.|:  :.:||..|.|....|..|.|.:.::....|
  Fly   259 NITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL---- 319

Mouse   312 IDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGI 376
             .|.....|.|.......||..|..|...::....|..||.:.|||.|:|:.:||..:|:..||.
  Fly   320 -GIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGF 383

Mouse   377 RKIGYW---------NEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLK--KNANQFE 430
            ..:..|         |:|::     ::.:.|   ..:.|:|:||::.|..|::.|:  :......
  Fly   384 LDLATWDPVNGLDVLNDDEE-----SEKRVG---QKLSNKTFIVSSRLGAPFLTLREPQEGEILT 440

Mouse   431 GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTI 495
            ||.|||||.::|..||||.:.:.:...:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:
  Fly   441 GNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTM 505

Mouse   496 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 560
            |..|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.
  Fly   506 TSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARM 570

Mouse   561 SPYEWHS-------EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGV 618
            :|.:|.:       ||.|           |.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:
  Fly   571 APDDWENPHPCKEPEEVE-----------NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGM 624

Mouse   619 WWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEK 683
            ||||.|::::|||||||||||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.::|
  Fly   625 WWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQK 689

Mouse   684 MWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGI 748
            |||.|:||.||||.:|.:||:.||:|.|..||:|:|||..||..:|| ||.:::||.||.|.|||
  Fly   690 MWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGI 753

Mouse   749 ATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWW---YDKGECGSKDSGSKDKTSALSLSNVAGVF 810
            |.|..|..|..::.|||||.|.|.|.:||.|||   :..|.|...|....| |..|.|.||.|||
  Fly   754 AMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVF 817

Mouse   811 YILIGGLGL--AMLVALIEFCYKSRSESKRMKGFCLIPQQSINEA------------IRTSTLPR 861
            .:|  ||||  ||::...||.:       .:|...:..:.|:.||            |.|..:..
  Fly   818 LVL--GLGLLSAMVLGCTEFLW-------NVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHT 873

Mouse   862 NSGAGASGGSGSGEN-------GRVVSQDFPKS--MQSIPCMSHSSGMPLGA 904
            :|.:|:|..|.|..:       .:.:|....||  .|.:....||....:|:
  Fly   874 SSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGS 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_001106796.1	PBP1_iGluR_AMPA_GluR1	26..389	CDD:107385	94/386 (24%)
		ANF_receptor	37..372	CDD:279440	87/349 (25%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	174/393 (44%)
		Glutamate binding. {ECO:0000250}	492..494		1/2 (50%)
		Lig_chan	538..817	CDD:278489	133/289 (46%)
		Glutamate binding. {ECO:0000250}	668..669		1/1 (100%)
		PDZ-binding	904..907		0/2 (0%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	92/377 (24%)
		ANF_receptor	39..379	CDD:279440	87/347 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	173/385 (45%)
		Lig_chan	548..812	CDD:278489	126/277 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C111336236
eggNOG	1	0.900				E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830