Protein Alignment Gria1 and GluRIIB

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 868
• Identity: 245/868 - (28%)
• Similarity: 408/868 - (47%)
• Gaps: 92/868 - (10%)

Mouse    25 IQIGGLFPNQQSQEHAAFRFALSQLT--EPPKLLPQID-IVNISDSFEMTYRFCSQFSKGVYAIF 86
            |:||.:|.:.:.:...||..||.::.  .|...|..|. .|.:.||..:....|.....||.|||
  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIF 89

Mouse    87 GFYERRT---VNMLTSFCGALHVCFITPSFPVDTSN------QFVLQLRPE---LQEALISII-- 137
            |...:..   |.:|.:..|..|:.|   .:....||      |..:.:.|.   |..|...|:
  Fly    90 GPSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS 151

Mouse   138 DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEG--YRMLFQDLEKKKERLV 200
            ..:.|::|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.:...:|:.|
  Fly   152 KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNAREKFV 212

Mouse   201 VVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAR 265
            ::||.|:.|..::...:.....|...|..|.||   |..|       :.:.||...::|..:.|.
  Fly   213 LLDCPSDILVDVINASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGFYSRDFTVAVAAV 267

Mouse   266 IMQQWRTSDARDH-----TRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLA 325
            .::.:......|.     ..||.:.....|.|.||.:.:...|.       ::||:|  .|..:.
  Fly   268 RIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIP 323

Mouse   326 NPAVP---WGQGIDIQRALQQVR-------FEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380
            |.:..   |..|..:...::|:.       |:  |..:|.|..|:|.::.|.|.....|.:..|
  Fly   324 NFSCGRGFWQPGPRLVEQMKQITPKMVKPPFK--TQRLQINADGQREDFNLEVYNPIIDRVTHI- 385

Mouse   381 YWNEDDKFVPAATDAQAGGDNSS-------VQNR--------TYIVTTILEDPYVMLKKNAN--Q 428
             ||::.:.|    |.:...:||:       :||:        .|.|.|.:..||...::...  .
  Fly   386 -WNKEFQLV----DFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVH 445

Mouse   429 FEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPL 493
            :|||:|:|||.|:|...:|:...:.:..|.|.|.|||:.|.:|..|:|::.:|:...|.:.:..|
  Fly   446 YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDL 510

Mouse   494 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 558
            |||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|....
  Fly   511 TITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTG 575

Mouse   559 RFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 623
            |...|||........|:.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::...||.|.
  Fly   576 RIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFA 637

Mouse   624 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYM 688
            |:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|........|..|
  Fly   638 LLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKM 702

Mouse   689 KSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG 753
            .|.:|..|.:..|||:.||:.|||.||:|:|:|..:|..||. |:..::|.:...|.||||.|..
  Fly   703 LSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLN 766

Mouse   754 SALRNPVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGL 817
            :..|:.:::.:|:|:|:|.|.||:|||: .::..|.|......|  ....:.:|.|:|.:||.|:
  Fly   767 ADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD--GQFDMDSVGGLFVVLIVGV 829

Mouse   818 GLAMLVALIEFCYKSRSESKRMK 840
            .:.:::.:.||.:..:..|.:.|
  Fly   830 VVGLVIGVAEFLWHVQRISVKEK 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	92/399 (23%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	135/391 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	89/390 (23%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	134/376 (36%)