Protein Alignment Gria1 and GluRIIC

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Alignment Length: 957
• Identity: 266/957 - (27%)
• Similarity: 429/957 - (44%)
• Gaps: 122/957 - (12%)

Mouse    13 LGAVVGANF-----PNNIQIGGLFPNQQSQEHAAFRFALSQLTEPP-----KLLPQIDIVNISD- 66
            ||.:..|.|     ...|.||..|.:.:.:....|...::.:..|.     :..|.|..:...|
  Fly     8 LGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDG 72

Mouse    67 SFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS----------NQF 121
            |..|....|.....||.||||...:...:::...|.:..:    |....|.|          :|.
  Fly    73 SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGI----PHIEFDISDEGIQAEKPNHQM 133

Mouse   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDAD--RGLSVLQRVLDTAAEKNWQVTAVNILTTT 181
            .|.|.|.   |.:|...|:.::.|:.|..:||||  |..:.||.:|......| .|..|... ..
  Fly   134 TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN-DVVRVRKF-HK 196

Mouse   182 EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKF--- 243
            ::.:|::::.:  :.||.||:|||...|..:|....:....|...|..|.||......|.:.
  Fly   197 DDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259

Mouse   244 -KESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYT--SALTYDGVKVMAEAFQ 305
             :....|:|..:|:...|..|..:...:.|.  ||:...:...|..|  ..|.:|.:::.|::::
  Fly   260 NETFAVNITAARLLVNPDPPPYSLPYGYVTQ--RDNIVYESSDPPRTLIHDLIHDALQLFAQSWR 322

Mouse   306 S---LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ------QVRFEGLTGNVQFNEKGRR 361
            :   ....|:.:.|  ...|..|:....|..|..:.|.::      ...|.  |..:||:|.|:|
  Fly   323 NASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFR--TSILQFDEDGQR 383

Mouse   362 TNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNA 426
            ..:.:.|.: ..||| .|..|:      |.....|...|..:.:...|.|.|.:..||....:.|
  Fly   384 ITFNIEVYD-PLDGI-GIAIWD------PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETA 440

Mouse   427 NQFE--GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVA 489
            .:..  ||..|:||.|:|...||:|||:.|....|:|.:||..|.:||.|||::||::...|.:.
  Fly   441 RELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMG 505

Mouse   490 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 554
            :..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.
  Fly   506 ICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMT 567

Mouse   555 FL---VSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 616
            ||   |:|.|..:|.:.. ...||....:  |::.|.|:.|.::.:.|..||||.|||...|:..
  Fly   568 FLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFE 629

Mouse   617 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVF 681
            ..||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||......|...|:
  Fly   630 ATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVY 694

Mouse   682 EKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGY 746
            ...:..|.:.:||.:.:...||:.||||::|.|.:|:|:|..|| .:.:.||...||.....|.|
  Fly   695 RLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHY 758

Mouse   747 GIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD-KGECGSGGGDSKDKTSALSLSNVAGVF 810
            .||.|.|:..|:.:::|:|||:|:|.|..||.|||.: ...|..  ....|.|..::...:.|:|
  Fly   759 AIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE--EPDPDATPDMTFEELRGIF 821

Mouse   811 YILIGGLGLAMLVALIEF-------------CYKSRSESKRMKGFCL------------------ 844
            |.|..|:.:|.|:.:.||             .:|...:.:.....|:
  Fly   822 YTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRT 886

Mouse   845 IPQQSINEAI-------------RTSTLPRNSGAGASGGSGSGENGR 878
            .|::|:::::             |:|...|....|:...|||...||
  Fly   887 TPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	91/401 (23%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	143/386 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		8/22 (36%)
		PDZ-binding	904..907
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/404 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	142/377 (38%)
		Lig_chan	554..827	CDD:459656	101/281 (36%)