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Protein Alignment Gria1 and GluRIIC

DIOPT Version :9

Sequence 1:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	957	Identity:	267/957 - (27%)
Similarity:	429/957 - (44%)	Gaps:	122/957 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 LGAVVGANF-----PNNIQIGGLFPNQQSQEHAAFRFALSQLTEPP-----KLLPQIDIVNISD- 66
            ||.:..|.|     ...|.||..|.:.:.:....|...::.:..|.     :..|.|..:...|
  Fly     8 LGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDG 72

Mouse    67 SFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS----------NQF 121
            |..|....|.....||.||||...:...:::...|.:..:    |....|.|          :|.
  Fly    73 SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGI----PHIEFDISDEGIQAEKPNHQM 133

Mouse   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDAD--RGLSVLQRVLDTAAEKNWQVTAVNILTTT 181
            .|.|.|.   |.:|...|:.::.|:.|..:||||  |..:.||.:|......| .|..|... ..
  Fly   134 TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN-DVVRVRKF-HK 196

Mouse   182 EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKF--- 243
            ::.:|::::.:  :.||.||:|||...|..:|....:....|...|..|.||......|.:.
  Fly   197 DDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259

Mouse   244 -KESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYT--SALTYDGVKVMAEAFQ 305
             :....|:|..:|:...|..|..:...:.|.  ||:...:...|..|  ..|.:|.:::.|::::
  Fly   260 NETFAVNITAARLLVNPDPPPYSLPYGYVTQ--RDNIVYESSDPPRTLIHDLIHDALQLFAQSWR 322

Mouse   306 S---LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ------QVRFEGLTGNVQFNEKGRR 361
            :   ....|:.:.|  ...|..|:....|..|..:.|.::      ...|.  |..:||:|.|:|
  Fly   323 NASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFR--TSILQFDEDGQR 383

Mouse   362 TNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNA 426
            ..:.:.|.: ..||| .|..|:      |.....|...|..:.:...|.|.|.:..||....:.|
  Fly   384 ITFNIEVYD-PLDGI-GIAIWD------PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETA 440

Mouse   427 NQFE--GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVA 489
            .:..  ||..|:||.|:|...||:|||:.|....|:|.:||..|.:||.|||::||::...|.:.
  Fly   441 RELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMG 505

Mouse   490 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 554
            :..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.
  Fly   506 ICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMT 567

Mouse   555 FL---VSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 616
            ||   |:|.|..:|.:.. ...||....:  |::.|.|:.|.::.:.|..||||.|||...|:..
  Fly   568 FLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFE 629

Mouse   617 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVF 681
            ..||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||......|...|:
  Fly   630 ATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVY 694

Mouse   682 EKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGY 746
            ...:..|.:.:||.:.:...||:.||||::|.|.:|:|:|..|| .:.:.||...||.....|.|
  Fly   695 RLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHY 758

Mouse   747 GIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYD-KGECGSKDSGSKDKTSALSLSNVAGVF 810
            .||.|.|:..|..:::|:|||||:|.|..||.|||.: ...|  .:....|.|..::...:.|:|
  Fly   759 AIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASC--FEEPDPDATPDMTFEELRGIF 821

Mouse   811 YILIGGLGLAMLVALIEF-------------CYKSRSESKRMKGFCL------------------ 844
            |.|..|:.:|.|:.:.||             .:|...:.:.....|:
  Fly   822 YTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRT 886

Mouse   845 IPQQSINEAI-------------RTSTLPRNSGAGASGGSGSGENGR 878
            .|::|:::::             |:|...|....|:...|||...||
  Fly   887 TPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.