Protein Alignment Gria1 and Ir21a

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Alignment Length: 862
• Identity: 164/862 - (19%)
• Similarity: 296/862 - (34%)
• Gaps: 233/862 - (27%)

Mouse   140 YKWQTFV------YIYDADRGLS----VLQRVLDTAAEKNWQVTAVNILT-TTEEGYRM------ 187
            |.|...|      :..:.||..|    .:.|.|....:.|.::..|.:.. ..|..:|.
  Fly     3 YYWVALVLFTAQAFSIEGDRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVP 67

Mouse   188 LFQDLEKKKERLV-----VVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNK----- 242
            .||...:.:..|:     |.....|:.|:::|.:     |.|...|           |||
  Fly    68 TFQGNPRPRGELLASKFHVNSYNFEQTNSLVGLV-----NKIAQEY-----------LNKCPPVI 116

Mouse   243 ----FKESGANVTGFQLVNYTDTIP-----ARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVK 298
                |.|..   .|..|.|...|||     ..|...:...:.|..:.:|.....|...|:
  Fly   117 YYDSFVEKS---DGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLS----- 173

Mouse   299 VMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNV---------Q 354
                  ..|..::| :..:..:...|.:.:..|        .|:......|:.|:         .
  Fly   174 ------DPLMTRKI-LGPQTESRVVLVSRSTQW--------RLRDFLSSELSSNIVNLLVIGESL 223

Mouse   355 FNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPY 419
            ..:..|...|.|:..::..||:                      |.|:.|...::| ...|..|:
  Fly   224 MADPMRERPYVLYTHKLYADGL----------------------GSNTPVVLTSWI-KGALSRPH 265

Mouse   420 VMLKKNANQF----------------------------EGNDRYEGYCVELAAEIAKHVGYSYRL 456
            :.|..:..||                            .|..|::|....|...|:|.:.:|..:
  Fly   266 INLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDI 330

Mouse   457 EIVSDGKYGARDPDTKAWNGMVG----ELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGIS-- 515
                     ...|......|:|.    :::....|:.::.:.||  :|.::|.:   ||:|.|
  Fly   331 ---------TETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA---MSVGHSPD 381

Mouse   516 --IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTT 578
              ..|....|:.|...:.:.|..:.:|:.::..|:|....:....|.                |.
  Fly   382 CAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRL----------------TL 430

Mouse   579 SDQSNEFG-IFNSLWFSLG------AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 636
            |.....:| :.|..|:..|      :|..:....:.|..|.|::.|.:|.||:||.|.||.::.|
  Fly   431 SHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIA 495

Mouse   637 FLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTE 701
            |:|:......::|..||. ......|||..|..:.:|:.|......:::..|:      ||.:.:
  Fly   496 FVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSVD 553

Mouse   702 EGMIRVRKS-KGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG-------------YGIATPK 752
            ||:..|.:| ...||:|......||:.|....|.     |:..:.             .|...|:
  Fly   554 EGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSALHLSEECFALFQIGFLFPR 613

Mouse   753 GSALRNPVNLAVLKLNEQGLLDKLKNK--WWYDKGECG-----SGGGDSKD---KTSALSLSNVA 807
            .|..:..::..:|...:.||:.|:.|:  |...:...|     |.....::   :...|:.::..
  Fly   614 ESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTE 678

Mouse   808 GVFYILIGG--LGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGG 870
            |:|.::..|  ||...||            |:.:.|.....:|.|..:.:::.   :|.:.||.|
  Fly   679 GMFLLMALGYFLGATALV------------SEIVGGITNKCRQIIKRSRKSAA---SSWSSASSG 728

Mouse   871 SGSGENGRVVSQDFPKS 887
            |....|...:|.|..|:
  Fly   729 SMLRTNAEQLSHDKRKA 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613	50/296 (17%)
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	88/439 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881		6/23 (26%)
		PDZ-binding	904..907
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	20/118 (17%)
		Lig_chan	405..662	CDD:459656	61/284 (21%)