Protein Alignment Gria1 and Ir7c

DIOPT Version :10

• Sequence 1: NP_032191.2
• Gene: Gria1 / 14799
• MGIID: 95808
• Length: 907
• Species: Mus musculus
• Sequence 2: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Alignment Length: 462
• Identity: 92/462 - (19%)
• Similarity: 177/462 - (38%)
• Gaps: 96/462 - (20%)

Mouse   410 IVTTILEDPYVMLKKNANQFEGNDRY--EGYCVELAAEIAKHVGYSYRL---------EIVSDGK 463
            :|.|....|||:::.:.....|...:  ||.   :...:|:.:.::.:|         ||:.||.
  Fly   217 VVATFEHRPYVIIEDDPKTPGGRSIHGIEGL---IFRSLAERMNFTIKLVEQKDKNRGEILPDGN 278

Mouse   464 YGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 528
            :          .|::..:|.|..::.......:..|.:::..|..:.|..|.:::.......| :
  Fly   279 F----------TGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP-M 332

Mouse   529 FSFLDPLAYEIWMCIVFAYI-GVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLW 592
            .....|..|.||.||:.:.| |..::..|.....|          |.......:.|... |..:|
  Fly   333 GRLTRPFRYIIWSCILVSLIFGFVLICLLKITALP----------GLRNLVLGRRNRLP-FMGMW 386

Mouse   593 FSL--GAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLA 654
            .||  |..:     .:|:....|.:..:|...|||:.::||..|...|....|.|||:| :|.||
  Fly   387 ASLLGGLAL-----YNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLA 446

Mouse   655 KQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV---FVRTTEEGMIRVR--KSKGKY 714
            |..|              ||     :...:.|..|.:.|:.   .|.:.||.:.|:|  ...|..
  Fly   447 KDYE--------------FR-----ILPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGIT 492

Mouse   715 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATP-------------KGSALRNPVNLAVLK 766
            ..||:.|:|::..:..|           :|.:....|             ..|..:..::..::.
  Fly   493 VALLQPTVNQFDFRSGP-----------NKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMA 546

Mouse   767 LNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYK 831
            :...|::.:.: |.:.|:.:..|...:.:.|  .||:..::|:|....|...:|::|.::|....
  Fly   547 MMSSGIVARYR-KMYMDRIKRVSKRRNLEPK--PLSIWRLSGIFVCCAGLYLVALIVFILEILTT 608

Mouse   832 SRSESKR 838
            :....:|
  Fly   609 NHRRLRR 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gria1	NP_032191.2	PBP1_iGluR_AMPA_GluR1	26..392	CDD:380613
		PBP2_iGluR_AMPA_GluR1	406..787	CDD:270447	81/409 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	857..881
		PDZ-binding	904..907
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	13/74 (18%)
		Lig_chan	343..592	CDD:459656	63/297 (21%)