Protein Alignment Ces1e and Gli

DIOPT Version :10

• Sequence 1: NP_598421.1
• Gene: Ces1e / 13897
• MGIID: 95432
• Length: 562
• Species: Mus musculus
• Sequence 2: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Alignment Length: 577
• Identity: 172/577 - (29%)
• Similarity: 263/577 - (45%)
• Gaps: 98/577 - (16%)

Mouse    27 VDTVQGKVLGKYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMCFQD 91
            ||.|.|:              .:||||:|:|.||....||.||:....|..:: |..:.|.|.|
  Fly   168 VDRVMGE--------------CSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQ-AVDFGPACPQ- 216

Mouse    92 PV--TGQIVNDLLTNRKEKIPLQFSEDCLYLNIYTP-ADLTKSDRLPVMVWIHGGGLVLGGASTY 153
            ||  ||          ..|..:...|||||||:|:| .....:.:.||||:||||..:.|.::.:
  Fly   217 PVRYTG----------ATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLF 271

Mouse   154 DGLVLSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTI 218
            .|.:|::..:||||.:.||||..||.|||||:|.||:|.|||..||.||.|||..|.||..|:|:
  Fly   272 QGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITL 336

Mouse   219 FGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAGLV---KKNTRPLAEKIAVISGCKNTTSA 280
            ||..|||.|..:|:::|..:|:.:|.|::||.||....:   |...:..:..:..:.||...:|.
  Fly   337 FGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSW 401

Mouse   281 AMVHCLRQKTEEELLGTTLKLNLFKLDLHGDSRQ--SHPFVPTVLDGVLLP-------------- 329
            .:|:|||...           :.::|.....|.|  |.|:.|.:.....||
  Fly   402 KLVNCLRTGR-----------SFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWR 455

Mouse   330 ---KMPEEILAEKNFN-TVPYIVGINKQEFGWILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLN- 389
               :.||.::....|| .:.|:.|:..||..:.:....:..|. .:||.......:::..|..|
  Fly   456 FLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPY-YELDGRFFDQKIREHVFRYNY 519

Mouse   390 -LPEDAIAVAIEKYLRDKDYT-----GRN---KDQLLELIGDVVFGVPSVIVSRGHRDAGAPTYM 445
             |..:.:..|| ||:    ||     ..|   :||.:.::.|:.:..|...:.:...:...|.||
  Fly   520 TLNPNGVYEAI-KYI----YTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYM 579

Mouse   446 YEFQYSPSFSSEMKPDTVVGDHGDEIYSVFGAPIL------------RGGTSEEEINLSKMMMKF 498
            |..  :.:..:...|......|..|.|.:.|||.:            |...::.:.|:|...|:.
  Fly   580 YVL--NTTVEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQT 642

Mouse   499 WANFARNGNPNGQ---GLPHWPEYDQKEGYLQIGATTQQAQKL--KEKEVAFWTELL 550
            :.||||.|||..|   |:.....|..:..||.|..|...:..|  ::.|.||||:.|
  Fly   643 YTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYL 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ces1e	NP_598421.1	COesterase	23..546	CDD:395084	168/571 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
Gli	NP_476602.1	COesterase	137..695	CDD:395084	168/571 (29%)
		PRK13335	818..>918	CDD:139494