Protein Alignment Slc6a3 and CG8850

DIOPT Version :10

• Sequence 1: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 194/569 - (34%)
• Similarity: 304/569 - (53%)
• Gaps: 17/569 - (2%)

Mouse    33 LVKEQNGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGA 97
            ::....|.:||    ||.........:|:.||:.::||.|.|..:|.|.||||||::..:|||||
  Fly    34 VIYSAEGEELT----INCEAESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGA 94

Mouse    98 FLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAW 162
            ||:||::.:::.|.|::|:|:.:|||:..|....:.:.|:::|:.:..:..:.....:|..|:|.
  Fly    95 FLIPYVIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMAL 159

Mouse   163 ALHYFFSSFTMDLPWIHCNNTWNSPNC--SDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQ 225
            .:.|..:||:..|||.:|...|.. :|  :.|.::|.|     :...|.:.|..:|.:.||...:
  Fly   160 TIRYLVASFSEVLPWTYCLVEWGK-SCVATGATAANDS-----SIVQGVSSAELFFTQTVLREPE 218

Mouse   226 SRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAM 290
            |...:.||.|.|.|..||:...|::...|.||:::|||..:..|..|||::..||:|.||||||.
  Fly   219 SLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALFPYVIMIVLLIRAVTLPGAW 283

Mouse   291 DGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLT 355
            .||..:|...:.:|....||..|.||:.|||.:.||.|:.::|:|.|..|.::|.||.|:|:|||
  Fly   284 QGIVYFLKPQWSQLLNPHVWYAAITQMFFSLAICFGTLVMYASFNDFNKNVHKDVIIITTIDSLT 348

Mouse   356 SFSSGFVVFSFLGYMAQKHNV-PIRDVATDGPGLIFIIYPEAIATLP-LSSAWAAVFFLMLLTLG 418
            |..:|.::|..||.:|.:.|. .|..|...|.||.||.||||||... |...:|.:||.|||.||
  Fly   349 SILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIAKFKYLPQLFAVLFFFMLLVLG 413

Mouse   419 IDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSI 483
            |.|.:|...:|:..:.|.|  .|....|..:...:..||..|..:|.||.:|..|:|.:......
  Fly   414 IGSNIGMASAVVNVVKDRF--THLPHWLLAVSASIIGFLCGLVYMTPGGQFVLNLVDFYGCTFIA 476

Mouse   484 LFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYG 548
            |...:.|.:.|.|.|||::...||:.|...:.:.|||:||.:|:|..:..|:|..:.::.|..|.
  Fly   477 LVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFYWRICWAIVAPGLMFLVLVYMLFSYEPLTYR 541

Mouse   549 AYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPG-SFREKLAYAITP 596
            ...:|......||||....:..:|.:|.......|| :|..|...|:.|
  Fly   542 GVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFGSKFGLAMQP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:444915	189/542 (35%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		9/29 (31%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	173/481 (36%)