DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BHLHE23 and Oli

DIOPT Version :9

Sequence 1:	NP_542173.2	Gene:	BHLHE23 / 128408	HGNCID:	16093	Length:	241	Species:	Homo sapiens
Sequence 2:	NP_001188830.1	Gene:	Oli / 35066	FlyBaseID:	FBgn0032651	Length:	232	Species:	Drosophila melanogaster

Alignment Length:	244	Identity:	98/244 - (40%)
Similarity:	123/244 - (50%)	Gaps:	58/244 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     5 PPGEPPSPGGAAMAELKSLS-GDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGG-DLPA 67
            |...||.........|.|:. |..|          |.|:  |.:::|....  ..|||.. :.|.
  Fly    35 PTASPPQSVPGRRTPLGSVGLGGFY----------AQGM--GMSQQPPTDE--NKPGPSAPEKPL 85

Human    68 APAPRAPAQAAESSGE-----QSGDEDDAFEQRRRRRGPGSAADGRRRPREQRSLRLSINARERR 127
            :|...|.|..|.|.|.     .||...          |.||.: |:::.|:.:::||:|||||||
  Fly    86 SPTAAAIAAIAISGGTTTVAVSSGGAS----------GSGSNS-GKQKNRQGKTVRLNINARERR 139

Human   128 RMHDLNDALDGLRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALDEMRRLVAFLNQGQGLAA 192
            ||||||||||.||:|||||||||||||||||||||||||||||..||:|:|||:|::....|
  Fly   140 RMHDLNDALDELRSVIPYAHSPSVRKLSKIATLLLAKNYILMQQNALEELRRLLAYIQSTTG--- 201

Human   193 PVNAAPLTPFGQATVCPFSAGAALGPCPDKCAAFSGTPSALCKHCHEKP 241
               ||||      .:..|.|.|.|              .||.:..|.:|
  Fly   202 ---AAPL------DLGAFPAAAKL--------------QALLQGPHNEP 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BHLHE23	NP_542173.2	bHLH_SF	111..191	CDD:412148	59/79 (75%)
Oli	NP_001188830.1	HLH	134..188	CDD:197674	49/53 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4633
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1617813at2759
OrthoFinder	1	1.000	-	-		FOG0002346
OrthoInspector	1	1.000	-	-		otm41513
orthoMCL	1	0.900	-	-		OOG6_106693
Panther	1	1.100	-	-	O	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5479
SonicParanoid	1	1.000	-	-		X1548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900