Protein Alignment CG43336 and PRSS2

DIOPT Version :10

• Sequence 1: NP_001247122.1
• Gene: CG43336 / 12798414
• FlyBaseID: FBgn0263041
• Length: 279
• Species: Drosophila melanogaster
• Sequence 2: NP_001290343.1
• Gene: PRSS2 / 5645
• HGNCID: 9483
• Length: 261
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 77/295 - (26%)
• Similarity: 115/295 - (38%)
• Gaps: 66/295 - (22%)

  Fly     1 MNVVVVGLTFFLLPLLGSTQFLDMACGIRAHSPSVPRVKNGTVASLTSSPWMAFLHSTDGRFICG 65
            ||:::: |||             :|..:.|......::..|.:....|.|:...|:|  |...||
Human     1 MNLLLI-LTF-------------VAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNS--GYHFCG 49

  Fly    66 GSLITNRLVLTAAHCF------------LDRTELVARLGEYDREEYEMCHDSYCTYRIEAMVERG 118
            ||||:.:.|::|.||:            .:...:..||||::.|..|.........:|
Human    50 GSLISEQWVVSAGHCYKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFINAAKI------- 107

  Fly   119 FRHRHYNPMTMAYDIAILRLYRKVQYTDNIRPICIVIDPRWRKYIDSLDPLTGT-----GWGKTE 178
            .||..||..|:..||.:::|.........:..|.:...|          |..||     |||.|.
Human   108 IRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAP----------PAAGTESLISGWGNTL 162

  Fly   179 SEGDS--AKLRTVDLARKHPEVCRRYATLSLTANQFCAG--NERSNLCNGDSGGPVGALIPYGKS 239
            |.|..  .:|:.:|........|.......:|.|.||.|  ....:.|.|||||||   :..|:.
Human   163 SSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPV---VSNGEL 224

  Fly   240 KRFVQVGIASFTNTQCVMVS---VFTDVMSYVDWI 271
            :..|..|..      |...:   |:|.|.:|||||
Human   225 QGIVSWGYG------CAQKNRPGVYTKVYNYVDWI 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43336	NP_001247122.1	Tryp_SPc	37..271	CDD:214473	68/257 (26%)
PRSS2	NP_001290343.1	Tryp_SPc	24..256	CDD:238113	70/258 (27%)