Protein Alignment CG43336 and KLK2

DIOPT Version :10

• Sequence 1: NP_001247122.1
• Gene: CG43336 / 12798414
• FlyBaseID: FBgn0263041
• Length: 279
• Species: Drosophila melanogaster
• Sequence 2: NP_005542.1
• Gene: KLK2 / 3817
• HGNCID: 6363
• Length: 261
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 74/277 - (26%)
• Similarity: 111/277 - (40%)
• Gaps: 60/277 - (21%)

  Fly    22 LDMACGIRAHSPSVP----RVKNGTVASLTSSPWMAFLHSTDGRFICGGSLITNRLVLTAAHCFL 82
            |.:.|     :.:||    |:..|......|.||...::| .|...|||.|:..:.|||||||..
Human    10 LSVGC-----TGAVPLIQSRIVGGWECEKHSQPWQVAVYS-HGWAHCGGVLVHPQWVLTAAHCLK 68

  Fly    83 DRTELVARLGEYDREEYEMCHDSYCTYRIEAMVERGFRHRHYNPMTM-----------AYDIAIL 136
            ..:::  .||.::..|.|....       ...|...|.|..||...:           ::|:.:|
Human    69 KNSQV--WLGRHNLFEPEDTGQ-------RVPVSHSFPHPLYNMSLLKHQSLRPDEDSSHDLMLL 124

  Fly   137 RLYRKVQYTDNIRPICIVIDPRWRKYIDSLDPLTGT-----GWGKTESEG--DSAKLRTVDLARK 194
            ||....:.||.::.:          .:.:.:|..||     |||..|.|.  ....|:.|.|...
Human   125 RLSEPAKITDVVKVL----------GLPTQEPALGTTCYASGWGSIEPEEFLRPRSLQCVSLHLL 179

  Fly   195 HPEVCRRYATLSLTANQFCAG--NERSNLCNGDSGGPVGALIPYGKSKRFVQVGIASFTNTQCVM 257
            ..::|.|..:..:|....|||  ....:.|.||||||   |:..|     |..||.|:....|.:
Human   180 SNDMCARAYSEKVTEFMLCAGLWTGGKDTCGGDSGGP---LVCNG-----VLQGITSWGPEPCAL 236

  Fly   258 ---VSVFTDVMSYVDWI 271
               .:|:|.|:.|..||
Human   237 PEKPAVYTKVVHYRKWI 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43336	NP_001247122.1	Tryp_SPc	37..271	CDD:214473	68/256 (27%)
KLK2	NP_005542.1	Tryp_SPc	25..256	CDD:238113	69/257 (27%)