Protein Alignment CNGA1 and CG42260

DIOPT Version :10

• Sequence 1: XP_005248106.3
• Gene: CNGA1 / 1259
• HGNCID: 2148
• Length: 690
• Species: Homo sapiens
• Sequence 2: NP_001356969.1
• Gene: CG42260 / 37614
• FlyBaseID: FBgn0259145
• Length: 1269
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 233/558 - (41%)
• Similarity: 335/558 - (60%)
• Gaps: 55/558 - (9%)

Human    48 SASTSEESENENPHARGSFSYKSLRKGGPS---------QREQYLPGAIALFNVNNSSNKDQEPE 103
            ||||    .:.:|||.|..|     :|||.         ....:..||.:.......|:..|...
  Fly   494 SAST----VSHHPHAHGPPS-----QGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHH 549

Human   104 EKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNW 168
            :|.::...::.::                               ....:|...|.||:|...|.|
  Fly   550 QKPRRTASQRIRA-------------------------------ATAARKLHFVFDPAGRLCYYW 583

Human   169 LFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEE 233
            ...:::..:||:.::|.|..|.|:....:..|..|||:||.:||||:....||||||.|:|..:.
  Fly   584 SMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDA 648

Human   234 LKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIF 298
            |||...|.::..|.:|.|.|:|.|.||..:|:| ..:|..||::..|.:.|..|||..|||||:|
  Fly   649 LKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWAFMDRTERHTNYPNLF 712

Human   299 RISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTI 363
            |.:.|:.|:::|.|||.|:::.|.|..|||:..|||   :|.|...:.::|:.|.||.||.||||
  Fly   713 RSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYLQSYYWCTLALTTI 774

Human   364 GETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 428
            |:.|.|....|||||::..|.|:::|||::|::.:::::::|||.||||::|.:|.||..|.|..
  Fly   775 GDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPN 839

Human   429 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVL 493
            .::.:|||||||||..:|..||:..:..|||||:|||||||||||||:|.||.:.|||.|.||||
  Fly   840 HLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVL 904

Human   494 KLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG 558
            :|:|.::|||||||:||::|:||||:..|:|.||||:|.|....|..|||||||||||:  ..||
  Fly   905 RLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTAG 967

Human   559 NRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLE 596
            |||||:::|:||||||.|||.|:.:.|.|||.|:..||
  Fly   968 NRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLE 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNGA1	XP_005248106.3	Ion_trans	165..407	CDD:459842	97/241 (40%)
		CAP_ED	479..595	CDD:237999	69/115 (60%)
		CLZ	595..664	CDD:465160	2/2 (100%)
CG42260	NP_001356969.1	Ion_trans	581..820	CDD:459842	99/242 (41%)
		CAP_ED	890..1004	CDD:237999	69/115 (60%)