DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNGA1 and CG42260

DIOPT Version :9

Sequence 1:	XP_005248106.2	Gene:	CNGA1 / 1259	HGNCID:	2148	Length:	765	Species:	Homo sapiens
Sequence 2:	NP_001356969.1	Gene:	CG42260 / 37614	FlyBaseID:	FBgn0259145	Length:	1269	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	233/558 - (41%)
Similarity:	335/558 - (60%)	Gaps:	55/558 - (9%)

- Green bases have known domain annotations that are detailed below.

Human   123 SASTSEESENENPHARGSFSYKSLRKGGPS---------QREQYLPGAIALFNVNNSSNKDQEPE 178
            ||||    .:.:|||.|..|     :|||.         ....:..||.:.......|:..|...
  Fly   494 SAST----VSHHPHAHGPPS-----QGGPGGPGPPHGGHPHHPHHGGAGSGGGSGPGSHGGQPHH 549

Human   179 EKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNW 243
            :|.::...::.::                               ....:|...|.||:|...|.|
  Fly   550 QKPRRTASQRIRA-------------------------------ATAARKLHFVFDPAGRLCYYW 583

Human   244 LFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEE 308
            ...:::..:||:.::|.|..|.|:....:..|..|||:||.:||||:....||||||.|:|..:.
  Fly   584 SMVVSMAFLYNFWVIIYRFAFQEINRRTIAIWFCLDYLSDFLYLIDILFHFRTGYLEDGVLQTDA 648

Human   309 LKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIF 373
            |||...|.::..|.:|.|.|:|.|.||..:|:| ..:|..||::..|.:.|..|||..|||||:|
  Fly   649 LKLRTHYMNSTIFYIDCLCLLPLDFLYLSIGFN-SILRSFRLVKIYRFWAFMDRTERHTNYPNLF 712

Human   374 RISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTI 438
            |.:.|:.|:::|.|||.|:::.|.|..|||:..|||   :|.|...:.::|:.|.||.||.||||
  Fly   713 RSTALIHYLLVIFHWNGCLYHIIHKNNGFGSRNWVY---HDSESADVVKQYLQSYYWCTLALTTI 774

Human   439 GETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSK 503
            |:.|.|....|||||::..|.|:::|||::|::.:::::::|||.||||::|.:|.||..|.|..
  Fly   775 GDLPKPRSKGEYVFVILQLLFGLMLFATVLGHVANIVTSVSAARKEFQAKLDGVKTYMRMRRVPN 839

Human   504 DMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVL 568
            .::.:|||||||||..:|..||:..:..|||||:|||||||||||||:|.||.:.|||.|.||||
  Fly   840 HLQVKVIKWFDYLWLTQKCSDEERAVSCLPDKLKAEIAINVHLDTLKRVEIFQNTEAGFLCELVL 904

Human   569 KLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG 633
            :|:|.::|||||||:||::|:||||:..|:|.||||:|.|....|..|||||||||||:  ..||
  Fly   905 RLRPVLFSPGDYICRKGEVGKEMYIVNRGRLQVVADNGKTVMASLKAGSYFGEISILNM--GTAG 967

Human   634 NRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLE 671
            |||||:::|:||||||.|||.|:.:.|.|||.|:..||
  Fly   968 NRRTASVRSVGYSDLFVLSKKDMWDVLKEYPAARVRLE 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNGA1	XP_005248106.2	None
CG42260	NP_001356969.1	Ion_trans	581..819	CDD:334124	98/241 (41%)
		CAP_ED	890..1004	CDD:237999	69/115 (60%)
		DUF4655	1084..>1154	CDD:317882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5527
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820