DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Camk2a and AMPKalpha

DIOPT Version :9

Sequence 1:	XP_006525604.1	Gene:	Camk2a / 12322	MGIID:	88256	Length:	489	Species:	Mus musculus
Sequence 2:	NP_477313.1	Gene:	AMPKalpha / 43904	FlyBaseID:	FBgn0023169	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	104/265 - (39%)
Similarity:	151/265 - (56%)	Gaps:	20/265 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARD-HQKLEREARICRLLKHPNIVRLH 76
            |.|...||.|.|..|:.....:...:.|.||:|.:|:.:.| ..|:.||.:..:|.:||:|::|:
  Fly    28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLY 92

Mouse    77 DSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENL 141
            ..||.....::|.:.|:|||||:.||......|..|....|||:..|.:||:..:||||||||||
  Fly    93 QVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENL 157

Mouse   142 LLASKLKGAAVKLADFGLA-IEVEGEQQAWFGF----AGTPGYLSPEVLRKDPYGKP-VDLWACG 200
            ||...:.   ||:|||||: :.::||      |    .|:|.|.:|||:....|..| ||:|:||
  Fly   158 LLDHNMH---VKIADFGLSNMMLDGE------FLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCG 213

Mouse   201 VILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEA 265
            ||||.||.|..||.||....|:::||:|.  ||.||:  :..:..:|:.:||.::|.||....|.
  Fly   214 VILYALLCGTLPFDDEHVPTLFRKIKSGI--FPIPEY--LNKQVVNLVCQMLQVDPLKRANIEEI 274

Mouse   266 LKHPW 270
            .||.|
  Fly   275 KKHEW 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camk2a	XP_006525604.1	STKc_CaMKII	11..302	CDD:270988	104/265 (39%)
Camk2a	XP_006525604.1	CaMKII_AD	357..484	CDD:285524
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	104/265 (39%)
		UBA_AID_AMPKalpha	297..360	CDD:270521
		AMPKA_C	457..580	CDD:213378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910