DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Camk2a and CASK

DIOPT Version :9

Sequence 1:	XP_006525604.1	Gene:	Camk2a / 12322	MGIID:	88256	Length:	489	Species:	Mus musculus
Sequence 2:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	131/307 - (42%)
Similarity:	189/307 - (61%)	Gaps:	17/307 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKK------LSARDHQKLEREARICRLL 67
            |.:.|:|.|.:|||.||:||||:...:.|::|.||::..|      ||..|   |:|||.||.:|
  Fly     8 FDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLSTAD---LKREATICHML 69

Mouse    68 KHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVARE----YYSEADASHCIQQILEAVLHCHQ 128
            |||:||.|.::.|.||..|::|:.:.|.:|..::|.|.    .||||.|.|.::|||||:.:||:
  Fly    70 KHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSEAVACHYMRQILEALRYCHE 134

Mouse   129 MGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQA--WFGFAGTPGYLSPEVLRKDPYG 191
            ..::|||::|...|||:....|.|||..||.||::.|.::.  ..|..|.|.|::|||:.:..||
  Fly   135 NDILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRETIETHGRVGCPHYMAPEVVTRRLYG 199

Mouse   192 KPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINP 256
            |..|:|..||:|::||.|..||..... ||.|.:..|...|.:|||.:::..||||:.|||..||
  Fly   200 KGCDVWGAGVMLHVLLSGRLPFLGSGV-RLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAANP 263

Mouse   257 SKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAI 303
            ..|::..|.|.||||..|..:.. .|..:||:.||::|||||||||:
  Fly   264 HHRLSITEVLDHPWIRDRDKLQR-THLADTVEELKRYNARRKLKGAV 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camk2a	XP_006525604.1	STKc_CaMKII	11..302	CDD:270988	128/302 (42%)
Camk2a	XP_006525604.1	CaMKII_AD	357..484	CDD:285524
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	129/304 (42%)
		S_TKc	12..278	CDD:214567	113/269 (42%)
		L27	347..396	CDD:280918
		L27	406..462	CDD:280918
		PDZ_signaling	493..573	CDD:238492
		SH3_CASK	586..646	CDD:213014
		Guanylate_kin	710..883	CDD:279019
		GuKc	720..883	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810