DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Camk2a and KP78b

DIOPT Version :9

Sequence 1:	XP_006525604.1	Gene:	Camk2a / 12322	MGIID:	88256	Length:	489	Species:	Mus musculus
Sequence 2:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	261	Identity:	98/261 - (37%)
Similarity:	144/261 - (55%)	Gaps:	9/261 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD 77
            |::.:.||||.|:.|:..:.:..|:|.|.|:|:...|:....|||.||..|.:.|.|||||||..
  Fly    63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQ 127

Mouse    78 SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLL 142
            .|..|...||:.:.|:|||||..:|......|.||....:|::.|:.:||...:||||||.||||
  Fly   128 VIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLL 192

Mouse   143 LASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKP-VDLWACGVILYIL 206
            |..::|   :|:||||.:...| .:.....|.|:|.|.:||:.|...|..| ||.|:.||:||.|
  Fly   193 LDQQMK---LKIADFGFSTTFE-PKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTL 253

Mouse   207 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271
            :.|..||...:...|..::..|.|..|.    .|:.|.:.||.|.|.:||::|.:.:..:...||
  Fly   254 VSGSLPFDGTNLKELRDRVLRGKYRVPY----YVSIECESLIRKFLVLNPTQRTSLSAVMADRWI 314

Mouse   272 S 272
            :
  Fly   315 N 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camk2a	XP_006525604.1	STKc_CaMKII	11..302	CDD:270988	98/261 (38%)
Camk2a	XP_006525604.1	CaMKII_AD	357..484	CDD:285524
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	96/258 (37%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	96/258 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910