DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRRK2 and cyr1

DIOPT Version :10

Sequence 1:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens
Sequence 2:NP_596159.1 Gene:cyr1 / 2540810 PomBaseID:SPBC19C7.03 Length:1692 Species:Schizosaccharomyces pombe


Alignment Length:1552 Identity:318/1552 - (20%)
Similarity:518/1552 - (33%) Gaps:507/1552 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   230 HSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHRLTLGNFFNI--------- 285
            |....||.. .|..||.      .|||.|.:|.:..:...| .|.|.......|::         
pombe    57 HEALSPCTQ-PVGNSGR------PVEAFKTYPSTPAVPSKS-VLFHFYEPDENFSLSDTGRTKSD 113

Human   286 --LVLNEVHEFVVKA----------VQQYPENAALQISALSCLALLTETIFLNQDLEEKNENQE- 337
              |...|..|   |:          ::.|.||.:.. .|:|..|.|...|..:::..:||.||. 
pombe   114 TALAARESSE---KSEVPRDTRSAGIKPYKENNSSN-CAISKEAGLRRLIDKDRESFDKNLNQSF 174

Human   338 ---------NDD----EGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHE--K 387
                     :||    |.:.|.|               |.:      |..:    .:.|:||  :
pombe   175 TNLTFPEPISDDSDSVEFQRDSL---------------NNN------WPAS----LEGSIHELPR 214

Human   388 IGDEDGHFPAHREVMLSMLMHSSS------------------------------------KEVFQ 416
            ..|:|| .||....:|.:..|..|                                    |:||.
pombe   215 NSDDDG-IPASAAHILDLDYHRDSYDSPWKKFLPYPSILSDDSWKAPESWGTSLPTEAIPKQVFT 278

Human   417 ASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLF---EGSNTSLD 478
            ....|..:|..:...| .:.:.:....:|..:....|.:.||    .|:|..||   ..:|..|.
pombe   279 TRFFARPSLGNRKKEF-FLRVYRDDRTSVSFICPIGIQTHEV----IKLLARLFFLPSSANFYLL 338

Human   479 IMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKLNMVKKQCFKN-DI 542
            ::.....:||.   .||... :..|.|.::....|....|.:.||.      ..|.:..|.. ||
pombe   339 LIQFNTERILL---PHEQPC-IIFERLLSLFGCKVTSDEEINEEDN------YSVARLVFTTMDI 393

Human   543 HKLVLAALN--RFIGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQM-YPDDQEIQC 604
            ...||...:  :...|..|.:..|:|| .:..:|.|.|::||     :|.|.|.: .|.|...:|
pombe   394 GADVLRKFSEKKITANLDISRSNLEVI-PVKIYPYAHELISL-----NVSHNLSLDLPLDFMERC 452

Human   605 LGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHH 669
            :.|..:.               ::..|.|.  |.|.:..::.      |.:|.:|.:..     :
pombe   453 VKLKRLD---------------ISNNLRSP--RGKPITALRQ------LEVLNMSRNDI-----Y 489

Human   670 SFDLVIFHQMSSNIMEQKDQQFLNLC-CKCFAKVAMDDYLKNV-MLERACDQNNSIMVECLLLLG 732
            ..|.:||..:|.|.:::     ||:. .|.|.......||.|: .|:  ...||.:....::...
pombe   490 ELDPLIFSGLSRNSLKE-----LNIANNKLFFLPHSTRYLVNLTYLD--LSYNNFVTFPLIITEL 547

Human   733 ADANQAKEGSSLICQVCEKESS-PKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRL-A 795
            :.........:|:.|:..|..| .||..|.|    :..|:...|...||         ||:.| .
pombe   548 SQLETLNFSHNLLSQISSKIGSLVKLKHLYL----QFNDLSNRLPQEIG---------LLKNLET 599

Human   796 LDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIAS-----TLARMVIRYQMKSAVEEG 855
            :|::.|:|                             |||||     .|..:.:...:.|..|..
pombe   600 IDLSYNAI-----------------------------TNIASLSECPKLNSINVACNLLSFYEYS 635

Human   856 TASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDA 920
            ..|.:           |.:::|.|.:::|..|:.|:           ||            |.| 
pombe   636 NPSAT-----------FIDFSFCPLTTIDPAFSYSN-----------LV------------YFD- 665

Human   921 VLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYIT 985
                               ..|..|:..|..::.:..::.:.|:  :..|..|||...|..:.:.
pombe   666 -------------------ISHAKLIGLKDSVIETLVNVETVKV--NYNHFTSISDAISAMQNLK 709

Human   986 SLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSN----- 1045
            .|..:..|:..:.....|      |:||..|:||.|.:..||:::.: :.||..::|.||     
pombe   710 YLSCTNCEMSYVSPNLGK------LKHLVHLDLHANNIKIFPEEVWQ-VSSLKVVNLSSNILEKI 767

Human  1046 --------KFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTV---------------------K 1081
                    |.|...|.|..|..::...||  .:.....:.|||                     |
pombe   768 KLPVATSKKLTRTISQLKIMRTLSGNPVS--SLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFK 830

Human  1082 CPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSE 1146
            |  ||..|||||.|:.:|.........|:.|.:.||:::              |||   |||.::
pombe   831 C--LKVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNELA--------------NLS---ISSTAQ 876

Human  1147 NFLEACPKVESFSARMNFLAAMP---FLPPSMTILKLSQNKFSCI------PEAILNLPHLRSLD 1202
            ..|      |:..|..|.|::.|   .|..|:..|.:|.|....:      .:::..||.|..|:
pombe   877 VLL------ETLYANGNRLSSFPKNEALSKSLRFLDISTNNLQNLAVEKAEKKSLTKLPQLEYLN 935

Human  1203 MSSNDIQYLPGPAHW------------KSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHN 1255
            :|.|.         |            ||. |:.|.|    :||:||:.|   :|......|:|.
pombe   936 LSGNT---------WFRFSEHEDTNFTKSY-LKNLKF----LSIMDLNTK---FSNAPSDVLNHF 983

Human  1256 KLKEIP-PEI------GCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL----DELHLNFDFK 1309
            ..:..| |.|      |.|.....:..:..|.:.:|.:....|..:.|..:    :...|.|.:.
pombe   984 IQRNSPQPNILRYGVCGYLSRSIPVISACELVVNNFLHPQSSLYCVLDSDISAGKNNRVLKFVYD 1048

Human  1310 HI-GCKAKDI------------------IRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLM 1355
            :: .|.|.:|                  :| |.::|...:.|: ::....|:..|...|    .|
pombe  1049 NLASCLAHEINAADSSSEQICNALRRGFLR-LNKKLGNVIHYD-LRKSSEGDVDSNYVT----TM 1107

Human  1356 KTKKSDLGMQSATVGIDVKDWPIQIRDKR-------------------------------KRDLV 1389
            ...:....|.|:.:.|.|....:.:||.|                               .||.:
pombe  1108 NISEKGYSMDSSCLDIGVSIILVYVRDTRAFVANVGTSMAIMSTRNDSEPTTLSVMHDVYNRDEI 1172

Human  1390 LNVWDFAGREEFYSTHPHFMTQRAL-------------YLAVYDLSKGQAEVDAMKPWLFNIKAR 1441
            ..:.|..|   |.|......|.||:             |:.|..||    |::.     |.|.|.
pombe  1173 RRIVDSCG---FISGEIKSTTTRAIGRLSQFPGVQAVPYVNVQYLS----ELNE-----FIILAN 1225

Human  1442 ASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEES--DALAKLRKTI 1504
            .....|:...|.:||....:....::. ||          :|||......|::  ..:.:|....
pombe  1226 QEFWSVLSKRTVIDVVRANRHSPLLAS-TK----------LRDYAIAYGAEKNVLVVIVELNGLF 1279

Human  1505 INESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEF--PVIDRKRLLQLVRE 1559
            ...||||        .||..|     ||.:....||..:.|  .:.|...|.::.||
pombe  1280 EENSLNF--------NQLRGD-----EKTLAISEKNDNMSFVQDLPDDSSLARMNRE 1323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736 1..969 161/827 (19%)
LRR 1. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 983..1004 2/20 (10%)
leucine-rich repeat 985..1012 CDD:275380 4/26 (15%)
LRR <1009..1279 CDD:443914 81/331 (24%)
LRR 2. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1012..1033 8/20 (40%)
leucine-rich repeat 1013..1036 CDD:275380 7/22 (32%)
LRR 3. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1036..1057 9/33 (27%)
leucine-rich repeat 1037..1084 CDD:275380 16/80 (20%)
LRR 4. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1059..1080 3/20 (15%)
LRR 5. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1084..1105 9/20 (45%)
leucine-rich repeat 1085..1108 CDD:275380 9/22 (41%)
LRR 6. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1108..1129 4/20 (20%)
leucine-rich repeat 1109..1130 CDD:275380 4/20 (20%)
LRR 7. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1130..1150 6/19 (32%)
leucine-rich repeat 1131..1174 CDD:275380 13/45 (29%)
LRR 8. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1156..1171 5/17 (29%)
LRR 9. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1174..1196 4/27 (15%)
leucine-rich repeat 1175..1197 CDD:275380 4/27 (15%)
LRR 10. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1197..1218 5/32 (16%)
leucine-rich repeat 1198..1221 CDD:275380 7/34 (21%)
LRR 11. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1221..1245 8/23 (35%)
leucine-rich repeat 1222..1246 CDD:275380 8/23 (35%)
LRR 12. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1246..1267 6/27 (22%)
leucine-rich repeat 1247..1269 CDD:275380 7/28 (25%)
LRR 13. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1269..1291 2/21 (10%)
RocCOR 1334..1507 CDD:206741 39/218 (18%)
COR 1527..1740 CDD:406489 9/35 (26%)
STKc_LRRK2 1884..2135 CDD:270970
WD 1. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2139..2183
WD 2. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2188..2228
WD 3. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2233..2276
WD 4. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2281..2327
WD 5. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2333..2377
WD 6. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2402..2438
WD 7. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2443..2497
cyr1NP_596159.1 Ad_cyc_g-alpha 155..200 CDD:129025 12/59 (20%)
RA_CYR1_like 294..391 CDD:340734 23/111 (21%)
leucine-rich repeat 409..430 CDD:275380 7/21 (33%)
LRR 430..>711 CDD:443914 78/418 (19%)
leucine-rich repeat 431..454 CDD:275380 8/27 (30%)
leucine-rich repeat 455..477 CDD:275380 5/38 (13%)
leucine-rich repeat 478..503 CDD:275380 7/29 (24%)
leucine-rich repeat 504..526 CDD:275380 6/26 (23%)
leucine-rich repeat 527..549 CDD:275380 3/23 (13%)
leucine-rich repeat 550..572 CDD:275380 4/21 (19%)
leucine-rich repeat 573..596 CDD:275380 9/35 (26%)
LRR 589..990 CDD:443914 115/545 (21%)
leucine-rich repeat 597..618 CDD:275380 9/49 (18%)
leucine-rich repeat 661..684 CDD:275380 7/54 (13%)
leucine-rich repeat 685..707 CDD:275380 6/23 (26%)
leucine-rich repeat 708..730 CDD:275380 4/27 (15%)
leucine-rich repeat 754..783 CDD:275380 6/28 (21%)
leucine-rich repeat 784..807 CDD:275380 4/24 (17%)
leucine-rich repeat 808..831 CDD:275380 1/22 (5%)
leucine-rich repeat 832..855 CDD:275380 9/22 (41%)
leucine-rich repeat 856..877 CDD:275380 10/37 (27%)
leucine-rich repeat 879..901 CDD:275380 7/27 (26%)
leucine-rich repeat 902..930 CDD:275380 4/27 (15%)
PP2C 1032..1268 CDD:395385 47/264 (18%)
Guanylate_cyc 1323..1519 CDD:425528 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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