Protein Alignment Hex-t1 and GCK

DIOPT Version :10

• Sequence 1: NP_788744.1
• Gene: Hex-t1 / 117364
• FlyBaseID: FBgn0042711
• Length: 465
• Species: Drosophila melanogaster
• Sequence 2: NP_277042.1
• Gene: GCK / 2645
• HGNCID: 4195
• Length: 466
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 139/446 - (31%)
• Similarity: 251/446 - (56%)
• Gaps: 15/446 - (3%)

  Fly    14 VYKVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERGQFLALEMM 78
            |.::...|....:||:|:...|.:|:..||..:.|:.::|....:||:..|.|.|.|.||:|::.
Human    17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLG 81

  Fly    79 PTNCRIMLVKFSSERD----IYTSSKCVIMPHTVAAGRGTEVFTFLATSIANFVKEKKVDKDNLP 139
            .||.|:||||.....:    :.|..:...:|.....|....:|.:::..|::|:.:.::....||
Human    82 GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLP 146

  Fly   140 LGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALAKFPEISVDVMGIINVGAGSL 204
            ||..|:|.::...:|.|||::|||.|.|.||.|.:||.|||||:.:..:..:||:.::|....::
Human   147 LGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATM 211

  Fly   205 LALCWAQPDTRIGLIMGSIANSCYVERVERCETYEGDEYRKLMIINSDWAHFGDTGQLDFIRNEY 269
            ::..:......:|:|:|:..|:||:|.::..|..||||.|  |.:|::|..|||:|:||....||
Human   212 ISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGR--MCVNTEWGAFGDSGELDEFLLEY 274

  Fly   270 DRQLDTESINPGTRIYEKFSGALCMGELVRIIVLRLMKSGAIFAEDRRDYIGIQWKLDMVSLIEI 334
            ||.:|..|.|||.::|||..|...||||||:::|||:....:|..:..:.:..:...:...:.::
Human   275 DRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQV 339

  Fly   335 VSDPPGVYTKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMR------L 393
            .|| .|...:...::....:|. ...|...::..|::|:.|||.:.::|::.:|:|||      :
Human   340 ESD-TGDRKQIYNILSTLGLRP-STTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDV 402

  Fly   394 PQISIAVDGGIYRLHPTFSTVLNKYTRLLADPNYNFEFVITQDSCGVGAAIMAGMA 449
            .:|::.|||.:|:|||:|....:...|.|. |:....|:.:::..|.|||:::.:|
Human   403 MRITVGVDGSVYKLHPSFKERFHASVRRLT-PSCEITFIESEEGSGRGAALVSAVA 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hex-t1	NP_788744.1	ASKHA_ATPase-like	24..446	CDD:483947	136/431 (32%)
GCK	NP_277042.1	ASKHA_NBD_HK4_meta	17..459	CDD:466942	139/446 (31%)