Protein Alignment: CHRNB2 and nAChRbeta2

• Sequence 1: NP_000739.1
• Gene: CHRNB2
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 212/488 (43%)
• Similarity: 301/488 (62%)
• Gaps: 66/488 (14%)

Human    27 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYR 91
            || :||.:.||  |.||:||||..|.:|.:||.|.:.|:|||.|:.:.|:||||:|:.|.|.||:
  Fly    29 DT-KRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYK 90

Human    92 LTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACK 156
            |.|.|||:..::::.:||:|||:||:|||||.||.|||:..:.|.:.|.|.:||.|||||||:|:
  Fly    91 LRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCE 155

Human   157 IEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEV---------ASLDDFTPSGEWDIVALPGRR 212
            :.|::||:|:|.|.|||.||||:..::||....::         ..|.:|..|.||||:.:|..:
  Fly   156 MNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATK 220

Human   213 NEN--PDD-STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLL 274
            ||.  ||. ..:.|||:...:|||.||||:|||:|||.:|.|.:||||||||.|||:|||||:|:
  Fly   221 NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILV 285

Human   275 ALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVF 339
            :||||.||:::|:|||||.|||:||||:|||:||:.|:.|:|||||:|.|||:||.|:|.|:.:|
  Fly   286 SLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLF 350

Human   340 LEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCT---CFVNRASVQGLAG 401
            |..:|.|:.|::.::                         ..|..|..|   .:.|...|:....
  Fly   351 LHFMPKLMMMRRTQY-------------------------TLPDYDDSTPSNGYTNEIDVRDSIS 390

Human   402 AFGAEPAPVAGPGRSGEPCGCGLREAVD------------------GVRFIADHMRSEDDDQSVS 448
            .|.:|...........     |::.:||                  .|||||.|::..|.|..:.
  Fly   391 DFPSEFKDSQDGAYDN-----GMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIV 450

Human   449 EDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480
            ||||:|:||:||.|||:|...|||||:.:..|
  Fly   451 EDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	Neur_chan_LBD	29..234	CDD:308532	99/217 (46%)
		Neur_chan_memb	241..478	CDD:308533	105/258 (41%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	211/483 (44%)
		Neur_chan_LBD	31..245	CDD:280998	99/216 (46%)
		Neur_chan_memb	252..479	CDD:280999	105/257 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR18945
Phylome	1	0.910		0.889	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920