Protein Alignment: CHRNB2 and nAChRalpha1

• Sequence 1: NP_000739.1
• Gene: CHRNB2
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 233/535 (44%)
• Similarity: 322/535 (60%)
• Gaps: 61/535 (11%)

Human     6 GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISV 70
            |.|.....|..|...:|.......:||.:.||  |.||:||||..|.|:.:||::.:.|:|||.|
  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV 64

Human    71 HEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNA 135
            :.:.||||||||:.|||.||:|.|.|:::..:..:.:||:||||||:||||||||.|||:..:.|
  Fly    65 NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA 129

Human   136 VVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVA-------- 192
            ::.:.|.:.|.|||||||.|:|:|::||||:|.|.|||.|||||...:||....:.|
  Fly   130 ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG 194

Human   193 -SLDDFTPSGEWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAI 253
             .|.|:..|.||||:.:|..|||   :..:..|:||.::..:|||.||||:|||||||.|:.|::
  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259

Human   254 LVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCV 318
            ||||||||.|||::||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.|
  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324

Human   319 LNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPR----------------HHCARQRLRLRRRQ 367
            |||:.|||.||.|||||:.:|::.||.||.:::|:                :|......:.....
  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYD 389

Human   368 RER----EGAGAL-----FFREAPGADSCTCFV---------------NRASVQGLAGAFGAEPA 408
            .:|    .|..||     |...|.|..|..||.               :..|..||.|.......
  Fly   390 SKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCC 454

Human   409 PVAGPGRSGE-------PCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIF 466
            |.|....:.:       |....:.:.::|.||||.|::::|..:||.|||||||||:||:|||||
  Fly   455 PAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIF 519

Human   467 VFVCVFGTIGMFLQ 480
            ...||.||..:.||
  Fly   520 AIACVVGTALIILQ 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	Neur_chan_LBD	29..234	CDD:308532	102/217 (47%)
		Neur_chan_memb	241..478	CDD:308533	119/284 (42%)
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	102/217 (47%)
		LIC	27..530	CDD:273305	226/505 (45%)
		Neur_chan_memb	247..530	CDD:280999	119/283 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H595
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR18945
Phylome	1	0.910		0.889	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920