Protein Alignment: CHRNB2 and nAChRalpha4

• Sequence 1: NP_000739.1
• Gene: CHRNB2
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_001097669.2
• Gene: nAChRalpha4
• FlyBaseID: FBgn0266347
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 221/506 (44%)
• Similarity: 305/506 (60%)
• Gaps: 49/506 (10%)

Human    23 VWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEW 87
            |.|....:||.:.||  |.||||:||..|.::::.|.:.:.|:|||.|:.:.||||||:|:.|.|
  Fly     6 VAGNPDAKRLYDDLL--SNYNKLVRPVVNTTDVLKVCIKLKLSQLIDVNLKNQIMTTNLWVEQSW 68

Human    88 EDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYK 152
            .||:|.|:|:|:..:..:.:||.|||.||:||||||||.:||:..:.|.:..:|.:.|.||||||
  Fly    69 YDYKLRWEPKEYGGVHMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYK 133

Human   153 SACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSE------VA---SLDDFTPSGEWDIVAL 208
            |:|:|:|::||||:|.|.:||.|||||..::||....|      ||   .|.:|..|.||||:.:
  Fly   134 SSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEQQGSNVVAVGVDLSEFYMSVEWDILEV 198

Human   209 PGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCI 270
            |..|||   ...|..|:|||::..:|||.||||:|:||||:.|:.|.:|.||||||.|||:||.|
  Fly   199 PAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSI 263

Human   271 SVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWV 335
            |:|::|.||.||:.:|:|||||.|||:||||:|.|:||:.||..:|.|||||.|||.||.|||||
  Fly   264 SILISLHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHKMAPWV 328

Human   336 KVVFLEKLPALLFMQQPRHHCARQRLRLR-----------------------RRQREREGAGALF 377
            |.||::.|||.||:::|.::....:|.|:                       .....:|......
  Fly   329 KRVFIDFLPAFLFIKRPTYNFETSKLLLKDTHACFYPYYSATNIDRLVSSGYNNSLPKEDLSQSI 393

Human   378 FREAPGADSCTCF-----VNRASVQGLA-------GAFGAEPAPVAGPGRSGEPCGCGLREAVDG 430
            ....|...||...     :...|...:|       |..|.:...:..|..|...|...:.::...
  Fly   394 TANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPLGMKSPILNNPAFSHSKCLPKIHKSCFC 458

Human   431 VRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480
            |||||:|.:.::|...|.|||||||||:||||||||....|.||.|:.||
  Fly   459 VRFIAEHTKMQEDSTKVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQ 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	Neur_chan_LBD	29..234	CDD:308532	100/217 (46%)
		Neur_chan_memb	241..478	CDD:308533	112/272 (41%)
nAChRalpha4	NP_001097669.2	LIC	1..505	CDD:273305	219/501 (44%)
		Neur_chan_LBD	12..227	CDD:280998	100/217 (46%)
		Neur_chan_memb	234..505	CDD:280999	112/271 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010