Protein Alignment CHRNB2 and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 513
• Identity: 118/513 - (23%)
• Similarity: 205/513 - (39%)
• Gaps: 135/513 - (26%)

Human     6 GP-----VALLLGFGLLRLCSGVWGTDTE----------ERLVEHLLDPSRYNKLIRPATNGSEL 55
            ||     :.:|:|..|:.|.|....|.|.          :||...|.  :.|:..::|...|:..
  Fly    13 GPGLPLLLQMLMGMLLMGLTSVPGATATADPKNANVKALDRLHAGLF--TNYDSDVQPVFQGTPT 75

Human    56 -VTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVL 119
             |:::::|:   .|.:.|....:||:.||...|.|....|:|.::||:.::.|.|..:|.|.:.|
  Fly    76 NVSLEMVVT---YIDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITL 137

Human   120 YNNADG--MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTE 182
            :|..:|  |.|    :...:|:||...|:|||:|.:.|::.:.::|.|:|:|.:|..||     .
  Fly   138 FNGDEGGLMAE----TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW-----G 193

Human   183 IDLVL------KSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINL 241
            :.:||      :.|....||...|.||:||   ..|........|..:.|....:|:...||..:
  Fly   194 LKVVLPENGTARGESLDHDDLVQSPEWEIV---DSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVI 255

Human   242 IIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTM 305
            ..|...|..||:..|:||... |||:.:...:::.:..||:..::::|..|.:.|||  .:.::.
  Fly   256 YTPASCIVILALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLV--VIFYST 318

Human   306 VLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRL--RLRRRQR 368
            .|:..|:.|.|.||                          :|::...:|   ::||  .||:...
  Fly   319 SLLYLSVSTIVEVL--------------------------VLYLATGKH---KRRLPEALRKLLH 354

Human   369 EREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRF 433
            ...|...|.                 ||....|...||.                       .:.
  Fly   355 GHLGTWLLL-----------------SVFSTTGESQAEK-----------------------TKE 379

Human   434 IADHMRSEDDDQSVSE----------------DWKYVAMVIDRL----FLWIFVFVCV 471
            :.:|...|.|:|..|.                ||..:|..:||:    |...|:.:.:
  Fly   380 MDEHPYEEADEQESSPLGINHTEVPGAKANQFDWALLATAVDRISFVSFSLAFLILAI 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	LIC	29..479	CDD:455710	109/485 (22%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	59/211 (28%)
		Cys-loop	155..169	CDD:349826	4/13 (31%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	110/485 (23%)