DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STK38 and wts

DIOPT Version :9

Sequence 1:	NP_001292031.1	Gene:	STK38 / 11329	HGNCID:	17847	Length:	465	Species:	Homo sapiens
Sequence 2:	NP_733403.1	Gene:	wts / 43651	FlyBaseID:	FBgn0011739	Length:	1105	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	211/490 - (43%)
Similarity:	299/490 - (61%)	Gaps:	54/490 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 TGSTPCSSMS----NHTK---ERVTMT--------------------KVTLENFYSNLIAQHEER 41
            ||:|..||.|    .|..   ||..::                    |..:|....|:|..:.:|
  Fly   607 TGTTASSSTSCKKIKHASPIPERKKISKEKEEERKEFRIRQYSPQAFKFFMEQHIENVIKSYRQR 671

Human    42 EMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLV 106
            ..|:.:|||.|.:.||.|:.:...|....:||:.::||||.::....|..||.||.||||||.||
  Fly   672 TYRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGEVTLV 736

Human   107 QKKDT-GHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLP 170
            .|.|| .|:||||.|||||:|::.||.|::||||||.|||:.||||::||||||.|||.:|:::|
  Fly   737 SKIDTSNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNNWVVKLYYSFQDKDNLYFVMDYIP 801

Human   171 GGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCT 235
            |||:|:||:|.....||..:|||||...|:||:|::|||||||||||:|:|..||:||:||||||
  Fly   802 GGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCT 866

Human   236 GLKKAHRTEFYR-NLNHSLPSDFTFQNMNSKRKAETWKRN---------------RRQLAFSTVG 284
            |.:..|.:::|: |.|||        ..:|....|.:..|               :|.||.|.||
  Fly   867 GFRWTHNSKYYQENGNHS--------RQDSMEPWEEYSENGPKPTVLERRRMRDHQRVLAHSLVG 923

Human   285 TPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPI 349
            ||:||||||..::||.:|||:||:|||:||||:|.|||.:.:|.||.:||:||::||..||:..:
  Fly   924 TPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSPLETQQKVINWEKTLHIPPQAEL 988

Human   350 SEKAKDLILRFCCEWEHRIGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFDEFP 414
            |.:|.|||.|.|...:.|:| ..|:|:||:.||:|:|:..:|::.|....|||...||||||...
  Fly   989 SREATDLIRRLCASADKRLG-KSVDEVKSHDFFKGIDFADMRKQKAPYIPEIKHPTDTSNFDPVD 1052

Human   415 ESDILKPTVATSNHPETDYKNKDW-VFINYTYKRF 448
            ...:.......|:..:.|..::.: .|..:|::||
  Fly  1053 PEKLRSNDSTMSSGDDVDQNDRTFHGFFEFTFRRF 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STK38	NP_001292031.1	Interaction with S100B. /evidence=ECO:0000269\|PubMed:14661952	62..87		7/24 (29%)
STK38	NP_001292031.1	STKc_NDR1	87..462	CDD:270777	182/380 (48%)
wts	NP_733403.1	STKc_LATS	717..1078	CDD:270749	178/369 (48%)
wts	NP_733403.1	S_TKc	719..1020	CDD:214567	161/309 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920