Protein Alignment ATXN2L and Atxn2l

DIOPT Version :10

• Sequence 1: XP_011544021.1
• Gene: ATXN2L / 11273
• HGNCID: 31326
• Length: 1104
• Species: Homo sapiens
• Sequence 2: XP_006507783.1
• Gene: Atxn2l / 233871
• MGIID: 2446242
• Length: 1102
• Species: Mus musculus
• Alignment Length: 1106
• Identity: 1047/1106 - (94%)
• Similarity: 1060/1106 - (95%)
• Gaps: 6/1106 - (0%)

Human     1 MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAA 65
            ||||||.||.||||||||||||||||.|||||||||||||||..:|||||||||.||||||.|||
Mouse     1 MLKPQPPQQTSQPQQPPPTQQAVARRSPGGTSPPNGGLPGPLTATAAPPGPPAAVSPCLGPAAAA 65

Human    66 GSGLRRGAEGILAPQPPPPQQHQERPGAAAIGSARGQSTGKGPPQSPVFEGVYNNSRMLHFLTAV 130
            |||||||||.|||...||  ||||||||.||||.|||:|||||||||||||||||||||||||||
Mouse    66 GSGLRRGAESILAASAPP--QHQERPGAVAIGSVRGQTTGKGPPQSPVFEGVYNNSRMLHFLTAV 128

Human   131 VGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIVDTMVFKPSDVMLVHF 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Mouse   129 VGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIVDTMVFKPSDVLLVHF 193

Human   196 RNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFN 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   194 RNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFN 258

Human   261 EENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEE 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   259 EENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEE 323

Human   326 KHSAVQRQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNS 390
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Mouse   324 KHSAVQRQGSGRESPSLVSREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNS 388

Human   391 SPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAAPPFLPVGRMYPPRS 455
            ||||||||||||||||||||||||||||||||||||||||||.||||..||.|||||||||||||
Mouse   389 SPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGEASVPPTSAALPFLPVGRMYPPRS 453

Human   456 PKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEP 520
            ||||||||:||||||||||||| .|||||||||||.|||.|||||||||:||.|||||||.||||
Mouse   454 PKSAAPAPVSASCPEPPIGSAV-ASSASIPVTSSVVDPGAGSISPASPKLSLTPTDVKELPTKEP 517

Human   521 GRTLEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGK 585
            .|.||.|||||||||||||||||||||||||||||||||||||||||..|||||.||||||.|||
Mouse   518 SRNLEAQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPETGLDPFPSRILKEEAKGK 582

Human   586 EKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGED 650
            ||||||||||:||||||||||||:.|||||.|:|..||||||||.|.||||||||||||||||::
Mouse   583 EKEVDGLLTSDPMGSPVSSKTESILDKEDKVPMAGVGGTEGPEQLPAPCPSQTGSPPVGLIKGDE 647

Human   651 KDEGPVAEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQ 715
            |:||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   648 KEEGPVTEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQ 712

Human   716 YISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQ-AAAA 779
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||
Mouse   713 YISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAA 777

Human   780 AGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSS 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   778 AGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSS 842

Human   845 TPQYPSAEQPTPQALYATVHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQQHQAGQAP 909
            |||||:|||||||||||||||||||||||||.|||||||||||||||||||||||| ||||||||
Mouse   843 TPQYPAAEQPTPQALYATVHQSYPHHATQLHGHQPQPATTPTGSQPQSQHAAPSPV-QHQAGQAP 906

Human   910 HLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIH-HQQLPHGFTNMAHVTQA 973
            ||||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||||||
Mouse   907 HLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHPHQQLPHGFTNMAHVTQA 971

Human   974 HVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQ 1038
            |||||:|||||||||||||||||||||||.||||||||||.||||||||||||||||||||||||
Mouse   972 HVQTGVTAAPPPHPGAPHPPQVMLLHPPQGHGGPPQGAVPPSGVPALSASTPSPYPYIGHPQGEQ 1036

Human  1039 PGQAPGFPGGADDRILCRVGRSHSRRRQGLAPGSVLCFPPSSLSCDPAAPLPTASPALSDPDCLL 1103
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1037 PGQAPGFPGGADDRILCRVGRSHSRRRQGLAPGSVLCFPPSSLSCDPAAPLPTASPALSDPDCLL 1101

Human  1104 T 1104
            |
Mouse  1102 T 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_011544021.1	SM-ATX	123..196	CDD:464173	71/72 (99%)
		LsmAD	264..326	CDD:461998	61/61 (100%)
		PHA03247	<336..949	CDD:223021	576/613 (94%)
		PAT1	797..>1035	CDD:401645	231/238 (97%)
Atxn2l	XP_006507783.1	SM-ATX	121..194	CDD:464173	71/72 (99%)
		LsmAD	262..324	CDD:461998	61/61 (100%)
		PHA03247	<401..946	CDD:223021	510/546 (93%)
		PAT1	755..>974	CDD:401645	214/219 (98%)