Protein Alignment ATXN2L and atxn2l

DIOPT Version :10

• Sequence 1: XP_011544021.1
• Gene: ATXN2L / 11273
• HGNCID: 31326
• Length: 1104
• Species: Homo sapiens
• Sequence 2: XP_031748418.1
• Gene: atxn2l / 100216248
• XenbaseID: XB-GENE-6000372
• Length: 971
• Species: Xenopus tropicalis
• Alignment Length: 1095
• Identity: 672/1095 - (61%)
• Similarity: 762/1095 - (69%)
• Gaps: 172/1095 - (15%)

Human     1 MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAA 65
            |||.|......:|...|..||       |....|||.|         |||
 Frog     1 MLKQQQAPPSRKPAMAPAQQQ-------GSPGSPNGNL---------PPG--------------- 34

Human    66 GSGLRRGAEGILAPQPPPPQQHQERPGAAAIGSARGQSTGKGPPQSPVFEGVYNNSRMLHFLTAV 130
            ||                  :.|:||||     .||::..|| .|.|||||||||||||||||||
 Frog    35 GS------------------RSQDRPGA-----GRGRNIVKG-LQPPVFEGVYNNSRMLHFLTAV 75

Human   131 VGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIVDTMVFKPSDVMLVHF 195
            |||||||:|:||..||||||||||:|||||||||:|.|:...||:||||||||:||||||.:|.|
 Frog    76 VGSTCDVRVRNGGVYEGIFKTLSSRFELAVDAVHKKTSDQVMGPKREDIVDTMIFKPSDVAVVGF 140

Human   196 RNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFN 260
            |||||||||||||||||||.:||||||||||||.||:||::::|||:|:||||||||||:|||||
 Frog   141 RNVDFNYATKDKFTDSAIATSSKVNGEHKEKVLMRWDGGEASNDDYELDSDMSNGWDPNDMFKFN 205

Human   261 EENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEE 325
            |:.|||||||||||||||:||||||||||||||:||.|||||||||||||.|||:||||.|||||
 Frog   206 EDTYGVKTTYDSSLSSYTIPLEKDNSEEFRQREMRATQLAREIESSPQYRARIAIENDDCRTEEE 270

Human   326 KHSAVQRQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRG-PHHLDN 389
            |||||||..|.|:||||.||:|||||||||||||.|||:|.||:|||||.:||:|.|| |.|...
 Frog   271 KHSAVQRPNSDRDSPSLGSRDGKYIPLPQRVREGARGGIRTSSARGGRPVMSSMPARGTPQHYPE 335

Human   390 SSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAAPPFLPVGRMYPPR 454
            :|..|..|.||:||||||||||||||:|..||:||||:||. |.|..|..|:       |.|||.
 Frog   336 TSSSPVPEQRGMNGGPSRMSPKAQRPIRCTKTMSSPSSRPV-EVSTSPSAAS-------RAYPPL 392

Human   455 SPKSAAPAPISASCPE-PPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKIS----------LA 508
            ||||.:    |.||.: .|:|:   :|.|::|...:.::|.:.. .|||||.|          :|
 Frog   393 SPKSGS----SVSCADSSPLGT---SSQATLPEPRAAAEPTLAP-KPASPKSSTPILLGEGKEIA 449

Human   509 PTDVKELSTKEPGRTLE---PQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPENSL 570
            |..|||.|     ||.|   |.::|:...||  ||.:|||.||:|||||||:|:|||||:|:...
 Frog   450 PAAVKEQS-----RTPEQVAPSQVAKQPCKV--LQTDQKRNQLDELRKFGAEFRLQPSSAPDPLS 507

Human   571 DPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPE-----QP 630
            :.||.|           :.|.|                    |.|.|||.:...||.|     :.
 Frog   508 ESFPLR-----------QRDTL--------------------EAKVPLAETAACEGVEPLDIKKV 541

Human   631 PP--------------PCPSQTGSPPVGLIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPLLSV 681
            |.              .||.::.||| |..:.|:|:|..|.:||||||||||||||||:||||||
 Frog   542 PELVEELKEERSCEVVECPEESASPP-GKAESEEKEEQAVCDQVKKSTLNPNAKEFNPSKPLLSV 605

Human   682 NKSTSTPTSPGPRTHST-PSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPG 745
            ||:||||||||||.||: .:||:|||||:|:|.| ||||||.|||..|||||||||||||:||||
 Frog   606 NKATSTPTSPGPRNHSSAATIPMLTAGQTGVYGP-YISYIPPIHMSSAVQAPQMYPYPVSSSVPG 669

Human   746 QQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQP 810
            |||||| ||||| |||||  ||.||||:||||||||||||||||||.||.|:||||||||.||||
 Frog   670 QQGKYR-AKGSL-PQRSD--QPNSAPPIMQAAAAAGPPLVAATPYSPYISYSPQQFPGQPTMMQP 730

Human   811 MAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLH 875
            ||||.|||||||||||||||||||:||||:||||.||||.|||||||.|||.|||||.|||.|||
 Frog   731 MAHYSSQPVFAPMLQSNPRMLTSGNHPQALVSSSNPQYPPAEQPTPQTLYAAVHQSYSHHAAQLH 795

Human   876 AHQPQPATTPTGSQPQSQHAAPSPVQQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQ 940
               ||||:|||.||.|.|||.|||| |||.||.|||.||||||||||...||.|||||.||||||
 Frog   796 ---PQPASTPTQSQQQPQHANPSPV-QHQTGQPPHLSSGQPQQNLYHTATLTATPPSLTPGPSAQ 856

Human   941 SPQSSFPQPAAVYAIH-HQQLPHGFTNMAHVTQAHVQTGITAAP---------PPHPGAPHPPQV 995
            |||||:|| .|||||| ||||.|.:|||:||.|||||||||.||         |||||||||.||
 Frog   857 SPQSSYPQ-QAVYAIHAHQQLQHSYTNMSHVAQAHVQTGITGAPPPPHPGAPHPPHPGAPHPAQV 920

Human   996 MLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGH--PQGEQPGQAPGFPGG 1048
            |||||.|:||||||.|:.|:||     |:||||.|:||  .|...|.|.|..|.|
 Frog   921 MLLHPSQTHGGPPQAAIQQTGV-----SSPSPYAYLGHHQVQSHPPQQLPFHPPG 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_011544021.1	SM-ATX	123..196	CDD:464173	56/72 (78%)
		LsmAD	264..326	CDD:461998	55/61 (90%)
		PHA03247	<336..949	CDD:223021	388/647 (60%)
		PAT1	797..>1035	CDD:401645	185/249 (74%)
atxn2l	XP_031748418.1	SM-ATX	68..138	CDD:464173	55/69 (80%)
		LsmAD	209..271	CDD:461998	55/61 (90%)
		PRK10263	<318..>862	CDD:236669	357/607 (59%)