DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATXN2L and atxn2l

DIOPT Version :9

Sequence 1:	XP_005255118.1	Gene:	ATXN2L / 11273	HGNCID:	31326	Length:	1104	Species:	Homo sapiens
Sequence 2:	XP_031748418.1	Gene:	atxn2l / 100216248	XenbaseID:	XB-GENE-6000372	Length:	971	Species:	Xenopus tropicalis

Alignment Length:	1095	Identity:	672/1095 - (61%)
Similarity:	762/1095 - (69%)	Gaps:	172/1095 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAA 65
            |||.|......:|...|..||       |....|||.|         |||
Frog     1 MLKQQQAPPSRKPAMAPAQQQ-------GSPGSPNGNL---------PPG--------------- 34

Human    66 GSGLRRGAEGILAPQPPPPQQHQERPGAAAIGSARGQSTGKGPPQSPVFEGVYNNSRMLHFLTAV 130
            ||                  :.|:||||     .||::..|| .|.|||||||||||||||||||
Frog    35 GS------------------RSQDRPGA-----GRGRNIVKG-LQPPVFEGVYNNSRMLHFLTAV 75

Human   131 VGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIVDTMVFKPSDVMLVHF 195
            |||||||:|:||..||||||||||:|||||||||:|.|:...||:||||||||:||||||.:|.|
Frog    76 VGSTCDVRVRNGGVYEGIFKTLSSRFELAVDAVHKKTSDQVMGPKREDIVDTMIFKPSDVAVVGF 140

Human   196 RNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFN 260
            |||||||||||||||||||.:||||||||||||.||:||::::|||:|:||||||||||:|||||
Frog   141 RNVDFNYATKDKFTDSAIATSSKVNGEHKEKVLMRWDGGEASNDDYELDSDMSNGWDPNDMFKFN 205

Human   261 EENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEE 325
            |:.|||||||||||||||:||||||||||||||:||.|||||||||||||.|||:||||.|||||
Frog   206 EDTYGVKTTYDSSLSSYTIPLEKDNSEEFRQREMRATQLAREIESSPQYRARIAIENDDCRTEEE 270

Human   326 KHSAVQRQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRG-PHHLDN 389
            |||||||..|.|:||||.||:|||||||||||||.|||:|.||:|||||.:||:|.|| |.|...
Frog   271 KHSAVQRPNSDRDSPSLGSRDGKYIPLPQRVREGARGGIRTSSARGGRPVMSSMPARGTPQHYPE 335

Human   390 SSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAAPPFLPVGRMYPPR 454
            :|..|..|.||:||||||||||||||:|..||:||||:||. |.|..|..|:       |.|||.
Frog   336 TSSSPVPEQRGMNGGPSRMSPKAQRPIRCTKTMSSPSSRPV-EVSTSPSAAS-------RAYPPL 392

Human   455 SPKSAAPAPISASCPE-PPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKIS----------LA 508
            ||||.:    |.||.: .|:|:   :|.|::|...:.::|.:.. .|||||.|          :|
Frog   393 SPKSGS----SVSCADSSPLGT---SSQATLPEPRAAAEPTLAP-KPASPKSSTPILLGEGKEIA 449

Human   509 PTDVKELSTKEPGRTLE---PQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPENSL 570
            |..|||.|     ||.|   |.::|:...||  ||.:|||.||:|||||||:|:|||||:|:...
Frog   450 PAAVKEQS-----RTPEQVAPSQVAKQPCKV--LQTDQKRNQLDELRKFGAEFRLQPSSAPDPLS 507

Human   571 DPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPE-----QP 630
            :.||.|           :.|.|                    |.|.|||.:...||.|     :.
Frog   508 ESFPLR-----------QRDTL--------------------EAKVPLAETAACEGVEPLDIKKV 541

Human   631 PP--------------PCPSQTGSPPVGLIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPLLSV 681
            |.              .||.::.||| |..:.|:|:|..|.:||||||||||||||||:||||||
Frog   542 PELVEELKEERSCEVVECPEESASPP-GKAESEEKEEQAVCDQVKKSTLNPNAKEFNPSKPLLSV 605

Human   682 NKSTSTPTSPGPRTHST-PSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPG 745
            ||:||||||||||.||: .:||:|||||:|:|.| ||||||.|||..|||||||||||||:||||
Frog   606 NKATSTPTSPGPRNHSSAATIPMLTAGQTGVYGP-YISYIPPIHMSSAVQAPQMYPYPVSSSVPG 669

Human   746 QQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQP 810
            |||||| ||||| |||||  ||.||||:||||||||||||||||||.||.|:||||||||.||||
Frog   670 QQGKYR-AKGSL-PQRSD--QPNSAPPIMQAAAAAGPPLVAATPYSPYISYSPQQFPGQPTMMQP 730

Human   811 MAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLH 875
            ||||.|||||||||||||||||||:||||:||||.||||.|||||||.|||.|||||.|||.|||
Frog   731 MAHYSSQPVFAPMLQSNPRMLTSGNHPQALVSSSNPQYPPAEQPTPQTLYAAVHQSYSHHAAQLH 795

Human   876 AHQPQPATTPTGSQPQSQHAAPSPVQQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQ 940
               ||||:|||.||.|.|||.|||| |||.||.|||.||||||||||...||.|||||.||||||
Frog   796 ---PQPASTPTQSQQQPQHANPSPV-QHQTGQPPHLSSGQPQQNLYHTATLTATPPSLTPGPSAQ 856

Human   941 SPQSSFPQPAAVYAIH-HQQLPHGFTNMAHVTQAHVQTGITAAP---------PPHPGAPHPPQV 995
            |||||:|| .|||||| ||||.|.:|||:||.|||||||||.||         |||||||||.||
Frog   857 SPQSSYPQ-QAVYAIHAHQQLQHSYTNMSHVAQAHVQTGITGAPPPPHPGAPHPPHPGAPHPAQV 920

Human   996 MLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGH--PQGEQPGQAPGFPGG 1048
            |||||.|:||||||.|:.|:||     |:||||.|:||  .|...|.|.|..|.|
Frog   921 MLLHPSQTHGGPPQAAIQQTGV-----SSPSPYAYLGHHQVQSHPPQQLPFHPPG 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATXN2L	XP_005255118.1	SM-ATX	122..191	CDD:291131	55/68 (81%)
		PBP1	209..750	CDD:227507	332/575 (58%)
		LsmAD	264..326	CDD:284215	55/61 (90%)
		TFIIA	763..>948	CDD:281188	149/184 (81%)
		TFIIA	882..>1074	CDD:281188	120/179 (67%)
atxn2l	XP_031748418.1	SM-ATX	68..138	CDD:405176	55/69 (80%)
		PBP1	154..681	CDD:227507	340/584 (58%)
		LsmAD	209..271	CDD:399606	55/61 (90%)
		PAT1	583..>865	CDD:401645	238/291 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	560	1.000	Domainoid score	I2854
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H16513
Inparanoid	1	1.050	1196	1.000	Inparanoid score	I2245
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D116171at7742
OrthoFinder	1	1.000	-	-		FOG0001866
OrthoInspector	1	1.000	-	-		oto148112
Panther	1	1.100	-	-	LDO	PTHR12854
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2220
SonicParanoid	1	1.000	-	-		X9068
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190