Protein Alignment CFTR and l(2)03659

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Alignment Length: 1497
• Identity: 407/1497 - (27%)
• Similarity: 719/1497 - (48%)
• Gaps: 276/1497 - (18%)

Human     1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK- 64
            :..:|..:::.:|.|.|.:|.||.|||||:.|:.:|:|:......:|.|..:|...|:|||.:.
  Fly    86 LPENPRARSNFISSLCFWYTIPIFRKGYRKTLDSTDLYRPLEEQKSDILGNRLCASWERELKNDG 150

Human    65 KNPKLINALRRCFFWRFMFYGIFLYLGEV-TKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLC 128
            ::|.|:.||.|.|.|:..|.|:.:::.|: .:.:||:.|.::| ||.....:..:...|..:...
  Fly   151 RSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQPIFLVKLI-SYFSGEPDAANAGFYYAVAQI 214

Human   129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDE 193
            ::..:..::|.|..||:||:..:||:||.|:|::|.|:|:...|...:.|.:|:|:||::.:.|.
  Fly   215 VISALTVMILTPTTFGIHHVCFKMRVAMGSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDS 279

Human   194 GLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISER 258
            .....|::|:.||||.::..|:::.:..||..|:.|:::....|..||......:.:.|.:...|
  Fly   280 APYTVHYLWVGPLQVLVITYLMYQEIGISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNR 344

Human   259 LVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVL 323
            :.:.:|:|..||.:|.|.||:..|:|:.:.|:.|:...|:..|:|.|:.:.........:|||::
  Fly   345 IRMVNEIISAIQVLKMYAWEQPFEQMVTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLV 409

Human   324 PYALIKGIILRKIFT-TISFCI-----VLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKT 382
            .|     :||.|:|| .|:|.|     ||..|::...|.|:......|.:|.:::.|:|.:|.
  Fly   410 GY-----VILGKVFTPEIAFMITAYYNVLLAAMSIYVPSAIIQTAQFLTSIRRVEQFMQSEEL-- 467

Human   383 LEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNN--NNRKTSNGDDSLFFSNFSLL--------G 437
                                 |..:..|...::.  .|..::|.:..|..|..|:.        .
  Fly   468 ---------------------GSSDKSEGPSKDTVPGNPPSNNNEADLLKSAISIRDLKAKWDPN 511

Human   438 TP--VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPG 500
            :|  .|..||.:|:.|.::||.|.||:||:||:..|:|||:.:.|:::.:|.:|:.||.||:..|
  Fly   512 SPDYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQVNGSLSYTSQESWLFSG 576

Human   501 TIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKD 565
            |:::||:||...|..||..|:|.|.||.|......:||.::||.|.||||||:|||||||:||:.
  Fly   577 TVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLSGGQKARISLARSVYRK 641

Human   566 ADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTF 630
            |.:||||.|...:|....:.:|:.||...:...|.:|||.:.:.|...|:|:||..|
  Fly   642 ASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVDQIVILANG-------- 698

Human   631 SELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGE 695
                                                                   ..|..|::..
  Fly   699 -------------------------------------------------------QIKALGDYES 708

Human   696 KRKNSILNPINSIR---KFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVIST 757
            ..|..::..:.|:.   |....::.||.:|..:..::        :.|..|..|   ..:...|:
  Fly   709 LLKTGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNE--------VTPIKENSE---QTVGGSSS 762

Human   758 GPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISE 822
            |.                     :::.|:.:..   :|||
  Fly   763 GK---------------------EHVERQESGG---ISLA------------------------- 778

Human   823 EINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAAS----LVVLWL 883
                                     .|.:|......|:..|:......||:||.:    .:..|:
  Fly   779 -------------------------LYRKYFQAGGGLVAFLVMLSSSVLAQVAVTGGDYFLTYWV 818

Human   884 LGNTPLQDKGNSTHSRNNS-----------YAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPL 937
            ...:.....|......:.|           .:||:..:||:.:|.|
  Fly   819 KKESTAAGHGEMEDMESKSMDVYKYTLIIILSVIMNLSSSFLLFNI------------------- 864

Human   938 VHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVI 1002
               ....|..||:.:.:.|.:|.|...:..|.|.|||||:||::.:|::||:.:.|.:|:.|.:.
  Fly   865 ---AKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDVMQIALWLA 926

Human  1003 GAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRA 1067
            |.|.|:|.:.|.:.|.|:.:.|.|..||..:|:||:.||::|:..|||:::||..||.||.|:||
  Fly   927 GIIIVIANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYSHLAASLNGLTTIRA 991

Human  1068 FGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGR-VGI 1131
            ...|...|..|....:.|::.:|:|:||.:.|...:..|.|| :|::..:|......|.|. ||:
  Fly   992 LDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVI-YISIITLSFFAFPPGNGADVGL 1055

Human  1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKF--------IDMPTEGKPTKSTKPYKNGQLS 1188
            ::|.||.::..:||.|..:.::::.|.:|.||.::        ::.|.:.||.|:
  Fly  1056 VITQAMGLIDMVQWGVRQTAELENTMTAVERVVEYESIEPEGMLEAPDDKKPPKT---------- 1110

Human  1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNA--ILENISFSISPGQRVGLLGRTGSGKS 1251
                           ||..|::..|:|..:||....|  :|:::||.|.|.::||::||||:|||
  Fly  1111 ---------------WPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKS 1160

Human  1252 TLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIW 1316
            :|::|..||..|:|.:.||......:.|...|:...:|||:..:||||.|.||||::::||:::|
  Fly  1161 SLINALFRLSYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLW 1225

Human  1317 KVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTY 1381
            ...:||.|:.|:...|..|...:.:||...|.|.:||:||||::|.:.:||::||.:|::||.|.
  Fly  1226 GCLEEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1290

Human  1382 QIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL--NERSLFRQAISPS 1444
            .:|:.|::..|.||||:...||:..:::..:.:|::..:|.::.|..:|:  ::..:|...::.|
  Fly  1291 GLIQATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQS 1355

Human  1445 DR 1446
            .|
  Fly  1356 GR 1357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	407/1497 (27%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		17/179 (9%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		15/63 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	407/1497 (27%)