Protein Alignment CFTR and CG11898

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1521
• Identity: 394/1521 - (25%)
• Similarity: 705/1521 - (46%)
• Gaps: 262/1521 - (17%)

Human     2 QRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQI-PSVDSADNLSEKLEREWDRELASKK 65
            |.:|:.||:..||.||.|||.||.||.::.|:.||:|:. ||::|. .:|..|...|::||...|
  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLEST-QVSSFLLGHWEQELKRSK 72

Human    66 NPKLINALRRCFFWRF----MFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYL-GI 125
             |.::..:.:.:.|.|    :.|.|.......|   |||:||.:::.:.....:....:.|| .:
  Fly    73 -PNVLRMIFKAYGWSFVPASIVYSIMAIAVHTT---QPLMLGGLVSFFSESTGKITKHSAYLYAM 133

Human   126 GLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNK 190
            |:.|..::..|..||.:..|..:|.::|:|...|:|:|.|::|....:....|..:||::.:|..
  Fly   134 GVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLPT 198

Human   191 FDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKI 255
            |:|.....|.:|..||:..:.:.:|::|:...|..|||.::.....||...|.:.:|:...|...
  Fly   199 FNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADVG 263

Human   256 SERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFL 320
            .||:.:.:|:|..:|.:|.|.||::..|:|..:|:.|:...|.:.|: |.............:||
  Fly   264 DERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYI-YAGLQCTGMISKLSLFL 327

Human   321 SVLPYALIKGIIL-RKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQE----- 379
            |::.|.....|:. :|:|...|:...|..::...:|.|:..|.::....|:::|||.:.|
  Fly   328 SLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENPADG 392

Human   380 ----YKTLEYN--------------LTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDD 426
                :|..|.|              .....:.:..::|.|::        .||...:|.
  Fly   393 GVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQ--------KKQEKRHRH------ 443

Human   427 SLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFC 491
                          ::|::|:.:..|.:.:.|:.||||::||.||:|||:...|.::.:|.:|:.
  Fly   444 --------------IEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYA 494

Human   492 SQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARI 556
            .|..|::.|::::||:|...|||.||..|::.|.|:.|:.:....|:..:||||.:|||||:||:
  Fly   495 PQEPWLLRGSLRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARV 559

Human   557 SLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHE 621
            |||||||:.||:||||.|...:|....|.:.:.|:.:.::.|.|||||.:::.|:..|.:::|..
  Fly   560 SLARAVYRKADIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEG 624

Human   622 GSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQS 686
            |                                             |.|::|.
  Fly   625 G---------------------------------------------RISVQGH------------ 632

Human   687 FKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPR 751
                              .::::|.                    :..|:|:..|.|..:
  Fly   633 ------------------YDALKKL--------------------IRFRMSVANDVEVAK----- 654

Human   752 ISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQET 816
                     |:|.|..||..                         .|:..        :.||||.
  Fly   655 ---------LRAMRTDSVYE-------------------------EPEPR--------KSLSQEE 677

Human   817 GLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITV--HKSLIFVLIWCLVIFLAEVAASLV 879
            .:: ..||.::      |.:.:.|.:|.. .||..|..|  |..::.:::...|:..:..|...:
  Fly   678 HMD-RHEIEQQ------FKEQQQIGSVKL-QTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDI 734

Human   880 VL--WLL--GNTPLQDKGNSTHSRNN-----SYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGL 935
            .|  |..  ...|.|.:....:.|..     .|..:|..|..:||          |...|||.
  Fly   735 FLSKWATWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYV----------LRTFGFFM-- 787

Human   936 PLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLI 1000
                ..:.:|..:|.::...|::|.|.......:|.||||||.|:..:|..||..:.|.|:..:.
  Fly   788 ----MTLRISLRIHDQLFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVN 848

Human  1001 VIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTL 1065
            .:..:|||:....::.:....|:......|..::..|:.||::|:..||||::|...:.|||.|:
  Fly   849 ALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATI 913

Human  1066 RAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISIL---TTGEGEG 1127
            ||.....|.|..||...|.:|:..:|::|..|.|....::|.|::.:||||..:|   ..|...|
  Fly   914 RALNGTKYMERDFHYYQNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSG 978

Human  1128 RVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMI 1192
            .||:.:|.:|.::...|..:..:::::::|.||.||.:::::|:|  |...|:
  Fly   979 DVGLAITQSMKLVLMCQAGMRQTVELENMMTSVERVMEYVNIPSE--PAYETE------------ 1029

Human  1193 IENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAF 1257
             |:.::.|.  ||||||:..:||..:|:..|..||:.::|:|...:::|::|.|.:|||:::.|.
  Fly  1030 -ESVNLPKH--WPSGGQLDFRDLRLRYSNHGPYILKGLTFTIRGEEKIGIVGHTAAGKSSIVHAL 1091

Human  1258 LRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEV 1322
            .||.:..|.|.|||.....:.|...|:...:|||...:|||:.|.||||:|:.:|:|:|...:.|
  Fly  1092 FRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSLRFNLDPFEEKTDEELWLALEAV 1156

Human  1323 GLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
            .|:..:......::..|.|.|...|.|.:||:||||::|.:.|||::||.:|::||.|..:|:..
  Fly  1157 KLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNKILIMDEATANVDPETDNLIQEA 1221

Human  1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH 1452
            :...||.|||:...||:..:::..:.:|::..:|.:.....:||:.|..:.........|....|
  Fly  1222 IHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHELLHNRHGYLHRFVEKTGVGTAQH 1286

Human  1453 -RNSSKCKSKPQIAALKEETEEEVQD 1477
             |:.::...:.::...|.|.:..|.|
  Fly  1287 LRHLAEQSYRKRVLGRKSEDQGSVLD 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	394/1521 (26%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		20/176 (11%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		19/93 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		6/27 (22%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480		394/1521 (26%)
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	386/1475 (26%)