Protein Alignment CFTR and rdog

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Alignment Length: 1535
• Identity: 414/1535 - (26%)
• Similarity: 725/1535 - (47%)
• Gaps: 248/1535 - (16%)

Human     3 RSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNP 67
            ::|..||:..|:..|.|.|.:.::|.:..|...::||......::.::.|....|:.|| .:.||
  Fly    12 KNPFTKANFFSQWSFWWMRDLFKRGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDEL-KRSNP 75

Human    68 KLINALRRCFFWRFMFYGIFLYLGE-VTKAVQPLLLGRII---ASYDPDNKEERSIAIYLGIGLC 128
            .::..:.|.:...|:..|:...:.| :.|::.||.||.::   |:...|..|..:....:||.:|
  Fly    76 SVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVGYFATNQTDISENTAYLYAMGIVIC 140

Human   129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDE 193
            :|  |..:..||.||.:..:|.::|:|:..|||:|.|::|....:....|:.:::|||:|.:||.
  Fly   141 ML--VPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGRAINILSNDLGRFDV 203

Human   194 GLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISER 258
            .|...|..|..|::..|:..|::..:..||..|:.|::.....||...:....||...|.:...|
  Fly   204 ALCFLHDTWKGPMESILIGFLMYREIGISAVIGVSFMLSFIPLQAWAAKKAAYYRQMTAERTDMR 268

Human   259 LVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVL 323
            :.:.:|:|:.||.:|.|.||::..::|..:|..|:|..|..||:..........|. ..|||::.
  Fly   269 VKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALGCTSMISP-LSVFLALC 332

Human   324 PYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFL------------ 375
            .|..: ..:..:|::|..|:..:|..::...:|.::....::|.:..:.:|||
  Fly   333 SYVYLGDPLTAQKVYTVSSYFNMLNDSMVTFWPMSITFIAEALVSAKRCKDFLLDGDKAEVPINL 397

Human   376 --------------QKQEYKTLEYN--------------------LTTTEVVMENVTAFWEEGFG 406
                          :|.:.|.:|.|                    .|...||::||:|.|:
  Fly   398 EANQQTGKNKRKISKKDKQKNVELNGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWD---- 458

Human   407 ELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
                          ||:|..:.           .::|.:..|:...|.||.|..||||:|.|.|:
  Fly   459 --------------TSDGHANC-----------AIEDFSTDIKDQTLAAVVGPVGAGKSSFLNVL 498

Human   472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536
            :||:...:|:....|:||:.||.||:..|||::||:|...|:|.||:.|:|.|.||.|:......
  Fly   499 LGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYNERRYKKVVKVCGLERDMELLPRG 563

Human   537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRI 601
            |..|:||.|::|||||:||:|||||||:.||:||||.|...:|....|.||:.|:...::||.||
  Fly   564 DLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAVDTHVGKHIFDRCIRDFLSNKIRI 628

Human   602 LVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETL 666
            |||.::::|...:.:|::..|.....|::.|||.                    .|:...|.:|.
  Fly   629 LVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQR--------------------SRQFQFLEQTQ 673

Human   667 HRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEP 731
            |..|......||...::..|.|..    |.:.|.:|.|                        ||.
  Fly   674 HDESGIDTHSVSSYLSRSDSEKSM----EHQHNQLLRP------------------------DEH 710

Human   732 LERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSL 796
            :|       |..|.:..:..|.:......::|.....:|.::                    :||
  Fly   711 VE-------DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIV--------------------ISL 748

Human   797 --APQANLTELDIY-SRRLSQETGLEISEE---INEEDLKECFFDDMESIPAVTTWNTYLRYITV 855
              ..:..||.:|.: ||.:..|..:.::..   :||.|....    .:::| :...:.|:
  Fly   749 FVCARIMLTGVDYFLSRWVIWEEQIAVNRTTTLLNETDTTIA----NDTLP-INATDPYI----- 803

Human   856 HKSLIFVLIWCLVIFLAEVAASL---VVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFY 917
                       ..:..:::.|.:   :||:                    ||.|:.:|...|:
  Fly   804 -----------APLLASDIQAGIRQELVLF--------------------YATILGATLIVYL-- 835

Human   918 IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAI 982
                    :...|||:      ..:.:|..||.::...:.:|.|...||..:|.|||||||||..
  Fly   836 --------IRTFGFFK------MCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRT 886

Human   983 LDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEG 1047
            :|..||.|:.|.:..::.|.|.:.:||:...::.:....:.|...|:|..::.||:.:|:|||..
  Fly   887 VDTDLPHTLLDCLAFIIDVSGVVIIVAIANYWLLIPAAIIGVILGMIRYLYVNTSRSVKRLESIS 951

Human  1048 RSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFI 1112
            |||:|:....:.:||.|:||...|...|..||:..|.:|:.|||:||..|.|.:..:::.:::..
  Fly   952 RSPVFSLTNQTFQGLTTIRALQAQSALEQEFHEYQNTNTSAWFLFLSCTRAFALWSDVLCIVYMT 1016

Human  1113 AVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPT 1176
            ||||..:|...| ..|.||:.:..:..:....||.:..:.::::.|.||.||.::.:.|:|.
  Fly  1017 AVTFSFLLLKDEFDSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEA--- 1078

Human  1177 KSTKPYKNGQLSKVMIIEN-SHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRV 1240
                           ::|. ...|....|||.|::...:...:|:.....:|::::|:|.|.:::
  Fly  1079 ---------------LLETPEKFKPKSEWPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKI 1128

Human  1241 GLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD 1305
            |::||||:|||:::.:..||...||.|:||.|..:.|.|...|....:|||...:||||.|.|||
  Fly  1129 GIVGRTGAGKSSIIQSIFRLACNEGMIRIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLD 1193

Human  1306 PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLD 1370
            |.::.||:|:||...:|.|||.:....|.|:..:.|||...|.|.:||:||||::|...|||::|
  Fly  1194 PMDERSDEEMWKALGDVELRSYVSTLIGGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMD 1258

Human  1371 EPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNER- 1434
            |.:|::||.|.::|::|::..||.|||:...||:..:::..:.||::..:||:.....:||...
  Fly  1259 EATANVDPETDKLIQQTIRSKFAHCTVLTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTG 1323

Human  1435 SLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEE 1474
            ...||.:..:.....|..:.:::.....||  |.::|..|
  Fly  1324 GYLRQLVDNTGAATSFALQQAAEQSYSKQI--LGDDTAAE 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	414/1535 (27%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		32/182 (18%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		22/90 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480		5/23 (22%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	406/1491 (27%)