Protein Alignment CFTR and Cftr

DIOPT Version :10

• Sequence 1: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1550
• Identity: 432/1550 - (27%)
• Similarity: 723/1550 - (46%)
• Gaps: 317/1550 - (20%)

Human     2 QRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL----A 62
            :::|.:.|:::|:|.|:|..|:|.:|.|:.|...|:.|....|.::.|.::||.:|.:||    .
  Fly     9 RKNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHR 73

Human    63 SKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASY------------------ 109
            .|:.|.|.|||.|||....:..|:..::..|.|.:.|.:|.:::..:
  Fly    74 KKQKPHLRNALFRCFLGPTIINGLICFIYIVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138

Human   110 -DPDNKEERSIAIYL-------------------------------------------------- 123
             |..|:..|:|..|:
  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203

Human   124 ----------GIGLCLLFIVRTLLLHPAIFGLHHI-------GMQMRIAMFSLIYKKTLKLSSRV 171
                      .:|..|  ::.||.   ..|.|||:       |.:||||..||||:|||:||.:.
  Fly   204 TVEHMWNDMNSLGAVL--VLSTLF---CCFLLHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKT 263

Human   172 LDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG-LGFLIVLAL 235
            ..:...|.|::||||::|:.|.|....|::||.|||..|...|||..:...|..| :|.|:....
  Fly   264 AGQTPAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVP 328

Human   236 FQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300
            .|..|.::....|.:.|.:...|:.|.:|:::.||.:|.|.||:..:.::...|::|:|..|.|:
  Fly   329 VQTALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYAS 393

Human   301 YVRYFNSSAFFFSGFFVVFLSVLPYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDS 364
            |:|.|..|...|:....:::::...||: :.|....:|:..|:..:|::.....:|.||....::
  Fly   394 YLRGFYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEA 458

Human   365 LGAINKIQDFLQKQEYKTLEYNLT---------TTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420
            |.::.:|||||..:..:.....||         :..|.::::.|.|:      .||.::
  Fly   459 LVSLRRIQDFLMLEGREERTQGLTHKRDQEGGDSRAVTIKDINASWD------IEKPQK------ 511

Human   421 TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
                               .|:.||.:||:|||.||.|..||||:|:|.:::|||...:|.:...
  Fly   512 -------------------TLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQ 557

Human   486 GRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550
            |.:|:.:|..|:..|:::.||:||..:|..||:.|.:.|.|..|..:....|..::||.|.:|||
  Fly   558 GDLSYAAQEPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSG 622

Human   551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV------CKLMANKTRILVTSKMEH 609
            ||||||||||||||.|.:||:|.|...:|....:.:|:..:      .:|.|  ||||||.::..
  Fly   623 GQRARISLARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKA--TRILVTHQVHF 685

Human   610 LKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGD 674
            |.:||.|:|:.:|.....||:.||.|...||:..|
  Fly   686 LSEADVIVIVDQGRILRQGTYQELINSDLDFARLL------------------------------ 720

Human   675 APVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLV 739
                  |..|:.     |.||..:|               |.:||.:|.:|.|.::
  Fly   721 ------ERPKEE-----EEGENSRN---------------QTSPLSVNSLESDDED--------- 750

Human   740 PDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTE 804
                     :|.|..:..|  .|..|:||            .::|...:..:           |:
  Fly   751 ---------IPFIDGVKDG--YQQLRKQS------------SSVHGSKSLDS-----------TQ 781

Human   805 LDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLR---YITVHKSLIFVLIWC 866
            ||               :.::|:||.|.......| |.|  |..|..   .:.....::||::..
  Fly   782 LD---------------DNVDEDDLAEAQASGGIS-PRV--WYEYFHAGSTLLSFSFMVFVMVMS 828

Human   867 LVI-----FLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTL 926
            .|:     |.|.:       |.          ...|.|:...|..    |::...|||..:...:
  Fly   829 QVVCSSSDFFANI-------WT----------QQEHQRSQGEATF----STFECMYIYGALIIAV 872

Human   927 LAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTI 991
            :.|..|||.......:..||:||.:|...:|.|.|...:|..:|.||||||||:..:|:|||..:
  Fly   873 VIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSKDMGAIDELLPRAM 937

Human   992 FDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLV 1056
            .||||:.|::.|.:.|:.:|.|.:..|.:.|.|..:::...:|:.||.||:||...|||:|:||.
  Fly   938 MDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLS 1002

Human  1057 TSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILT 1121
            .||.||..:|:...|......|....::|::.|.|.::......:.::.:..||..:|||..|::
  Fly  1003 ASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSCIFLTSVTFSFIIS 1067

Human  1122 TGEG-EGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNG 1185
            :... .|.||:.:..||.:...:|:.|....:....|.||.||.::.::..|....:.|.|.:
  Fly  1068 SETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQEPALGEKTPPQQ-- 1130

Human  1186 QLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
                              ||:.||:..::::.:|...|:.:|.|::.:|..|.:||::||||:||
  Fly  1131 ------------------WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVGRTGAGK 1177

Human  1251 STLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEI 1315
            |:|:.|..||.:.||||.|||:...:|:|:..|....:|||...:||.|.|.||||:|:::|.|:
  Fly  1178 SSLIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAEL 1242

Human  1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
            |...::|.||..|   || ||:::.:.|...|.|.:||:||||::|...|:|:|||.:|::||.|
  Fly  1243 WSALEDVELRKAI---PG-LDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQT 1303

Human  1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
            ..:|:||::..|..|||:...||:..:::..:.:|::.....::| :..||.::|
  Fly  1304 DALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFD-VPYLLLKKS 1357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	431/1549 (28%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		26/176 (15%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	431/1544 (28%)