Protein Alignment ADCY2 and ACXB

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_620474.2
• Gene: ACXB / 53427
• FlyBaseID: FBgn0040509
• Length: 1114
• Species: Drosophila melanogaster
• Alignment Length: 1185
• Identity: 320/1185 - (27%)
• Similarity: 533/1185 - (44%)
• Gaps: 217/1185 - (18%)

Human     4 EAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFAL 68
            |.:..|.||:.:.:|                   .|:.:::......|:|...:....|.:|..:
  Fly    19 ERLWERGYLKAKCKE-------------------LCLEEEYKKYQIRLMISYLTVFFPLFIFVVV 64

Human    69 GLEV------EDH----------VAFLITVPTALAI-FFAIFILVCIESVFKKLLRLFSLVIWIC 116
            |.|:      |..          :..|:.||..|:| ||..|:|      ..:.:.:||.::...
  Fly    65 GCELCPWIFSEQKKLIYYESLTAIVVLVAVPGILSINFFESFVL------RHRWIMVFSSILSAY 123

Human   117 LVAMGYLFMCFGGTVSPWDQVSFF-------------LFIIFVVYTMLPF-NMRDAIIASVLTSS 167
            :|.:..:|           |:..|             :|::.::|..||. ::|.   |::|.:|
  Fly   124 IVVLVDIF-----------QILVFHFKYHWPLNTLYDVFVLCMIYMFLPIPSIRG---AALLATS 174

Human   168 SHTIVLSVCLSATPGGKE------HLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNC 226
            ...:.:.:.:.......|      |.:..|..::..::..||.|.:.:.:.:..::.::.|....
  Fly   175 VSLMYIGLFIYFLKSDDEDISEVVHDLDTICVDIFHYLGFNLMGIFFRIMNDTMVRSSFLDRHQF 239

Human   227 IKSRIKLEFEKRQQERLLL-SLLPAHIAMEMKAEIIQRLQGPKAG------QMENTNNFHNLYVK 284
            :|..:.|. :.||||.:|| |:||..||..::..|.:|:...:..      ....|.||  :.::
  Fly   240 LKEEMWLR-QARQQESMLLDSILPPQIAKPIQQSIKERIMLSETDSDRIVVNARRTENF--MAIQ 301

Human   285 RHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPI 349
            .|.:|||||||:|.:|.|.:..:..:||.:|::|:|:||..|...:..|||.||||||||:||..
  Fly   302 IHPDVSILYADVVNYTHLTTTLTVEKLVKVLHDLYGRFDMAASTFKVQRIKFLGDCYYCVAGLGE 366

Human   350 SLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLAN 414
            :.|:||:..|.:|:.|...|::||....:||:||:|||||.:|.||||..|.|||:|..||.:||
  Fly   367 ADPDHARMAVSLGISMIANIQEVRAHRALDIDMRIGVHSGTLLAGVIGQAKLQYDIWGPDVDIAN 431

Human   415 HMEAGGVPGRVHISSVTLEHLNGA-YKVEEGDGDIR-DPYLKQHLVKTYFVINPKGERRSPQHLF 477
            .:||.|.||.||:|..||..||.| |.|..|....: ||.|::..:.||.
  Fly   432 RLEATGKPGYVHVSGRTLSSLNVAEYTVFPGTEVAQSDPILQKQPMTTYL--------------- 481

Human   478 RPRHTLDGAKMRASVRMTRYLESW--------GAAKPFAHLHHRDSMTTENGKISTTDVPMGQHN 534
                 |..|..|.|||....:.|:        ||::....|  |.::.::..:.....:|:|..|
  Fly   482 -----LTAAPSRNSVRSVDAVHSYAEIDINALGASRKSPIL--RPTLMSDELREEFKKMPVGGFN 539

Human   535 FQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPA 599
            .::...|..|.    :|::|                   ..:....:.|.:..||..|.......
  Fly   540 IRSPCCRDNSN----DEKVN-------------------HGLGMFCVAFKDSSLEWSYLHKPDFI 581

Human   600 FKYYVTCACLIFFCIFIVQIL-----VLPKTSVLGI---SFGAAFLLLAFILFVCFAGQLLQCSK 656
            .||.|..|..|..|:..:||:     :..:..|:.:   :|..:.|.:::...||:...:...|:
  Fly   582 LKYSVLLAWGIGCCLIYIQIVNDKFTICVECIVIDMVVFTFLTSLLFISWFKKVCWWRCVENDSR 646

Human   657 KASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSA 721
            |...:...|.|.        |.||..:.:....|.|..|.:.:.|.   .||....:........
  Fly   647 KYGRVSCKLFKI--------WERIQHSFVLRVTIYMSIVASYYLLI---STILLNCDKNQYELDV 700

Human   722 SNNQV--AILRAQNLFFLPYFIYSCILGLISCS-VFLRVNYELKMLIMMVALVGYNTILLHTHAH 783
            .|:::  ..:...|. |.|:.....|..::..| .|.|:.:.|||||...|.|.|..|:...::.
  Fly   701 INSKLYHYDIVTDNC-FNPWVFTDMISLIVGVSYTFARIPFALKMLITCCATVAYLVIVFFQYSF 764

Human   784 VLGDYSQVLFERPGI---WKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEI 845
            :        ||....   :...:....:.:.:..:|:....||:|:..:::|......:.:::..
  Fly   765 I--------FEHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKINFKINQDLQGKQKAA 821

Human   846 ETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL 910
            :.......:||.|:||:||.|.:| .|:.|.|||:::|..|.||||.:.:|          :..|
  Fly   822 DITNKSIIILLTNILPSHVVEVYL-DSVANHELYYENYKMVSVMFAMLINF----------QMDL 875

Human   911 ECLRLLNEIIADFDDLLSKPK-FSGVEKIKTIGSTYMAATGL------SAVPSQEH--------- 959
            ..||:||:||.:||.||:..| :..|||||.:|.|||||.||      |...|:.|
  Fly   876 PSLRVLNDIITEFDRLLNAYKEYYVVEKIKVVGCTYMAACGLDFTLAKSKFGSRTHASYSSELEQ 940

Human   960 ------SQEPERQYMHIG-TMVEFAFALVGKLDAINK--------HSFNDFKLRVGINHGPVIAG 1009
                  |:..|..:..:. .|..||..|:..|...||        .:.:..::.:||:.|.::||
  Fly   941 VLYRKESKGTENDHDEVAFIMTTFALDLMRVLSVCNKAYAGRPFDRALSTGEICIGISTGEIMAG 1005

Human  1010 VIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTY 1074
            |:||.:|.||||||.||:||||:|||:...|.||:||:.:|:.....|..||:..|||:|::.||
  Fly  1006 VVGASQPHYDIWGNPVNMASRMESTGLPGHIHVTQETANILEQFDIMCMYRGMTFVKGRGEIPTY 1070

Human  1075 FVNTEMSRSLSQSNV 1089
            ||..:.:.....|||
  Fly  1071 FVGIDDNLKFLPSNV 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	138/456 (30%)
		Guanylate_cyc	281..465	CDD:425528	85/185 (46%)
		Adcy_cons_dom	495..600	CDD:461877	16/112 (14%)
		Guanylate_cyc	878..1077	CDD:425528	86/229 (38%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		7/16 (44%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		0/2 (0%)
ACXB	NP_620474.2	AcyC	85..452	CDD:441717	122/389 (31%)
		Nucleotidyl_cyc_III	298..484	CDD:448371	86/205 (42%)
		Nucleotidyl_cyc_III	853..1072	CDD:448371	85/228 (37%)