Protein Alignment ADCY2 and Ac76E

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Alignment Length: 1345
• Identity: 443/1345 - (32%)
• Similarity: 656/1345 - (48%)
• Gaps: 354/1345 - (26%)

Human    12 LRDRSEEAAGG-------GDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALG 69
            |.|.||:..|.       .|...|.|..|.:|.:    :..|:..||..|         |...:|
  Fly    50 LADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLF----RSGLLTSLLACV---------VSIIIG 101

Human    70 LEVEDHVAFLITVPTALAIFFAIF---ILVCIESVFKKLLRLFSLVIWICLV---AMGYLFMCFG 128
            :....|:     |.|.|.:..|:.   ||..::  |..:|...:..:...:|   ::|.:....|
  Fly   102 IVYGQHL-----VQTMLLVLAALISGSILTALQ--FPAVLSSPAAALAFAIVTTFSLGTIAAITG 159

Human   129 GTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILA 193
            ..::|....:.||    .:::|||.:...:::.::..::.|.:..   :..:|....:|. .:..
  Fly   160 DELAPLPMYALFL----CIHSMLPISWPVSVVLALFMTAIHIVYR---IGTSPDYAPNLP-MLFG 216

Human   194 NVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKA 258
            .:::....:::|.|::.:.:.|..:|...|...|:.|:|||.|:.|||:||||::||:||.|:|.
  Fly   217 EIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKR 281

Human   259 EIIQRLQG--PKAGQMENTN--NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELF 319
            .|:.::..  .:||...:|:  .||.|:|:|||||:||:||||.||.|:|..:..:||..||:||
  Fly   282 SIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLF 346

Human   320 GKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRV 384
            |:|||||:||:|:||||||||||||||||||.|.||.|||.|||.|.:||:.||:|||::::||:
  Fly   347 GRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRI 411

Human   385 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIR 449
            |:|:|||||||:||:|||:||||.|||||||||:|||.|||||:..||:.|...::||:|:|..|
  Fly   412 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNR 476

Human   450 DPYLKQHLVKTYFVINPK----------------------------------------------- 467
            |.||..|.|::|.::.||
  Fly   477 DAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLP 541

Human   468 ----------GERRSPQHL---------------------------------------------- 476
                      .|:.||..:
  Fly   542 VTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDG 606

Human   477 ----------------------------------------------------------------- 476
                                                                             
  Fly   607 KNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPT 671

Human   477 ---------------------------------FRPRHTLDGA---------------------- 486
                                             |..|....||
  Fly   672 AAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHV 736

Human   487 -KMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFE 550
             :.|.|.:||:|:|.|||.:|||::  .:|...:|  |....:.|.:.|.      ...::|.|.
  Fly   737 TRNRPSSKMTKYVECWGADRPFANI--AESKLVKN--IGLASIAMIESNL------LPPERKCFN 791

Human   551 EELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIF 615
            ...                :....:::..::.:.|...|..|||.....|::.:.||.::|..:.
  Fly   792 FNF----------------FGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLA 840

Human   616 IVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP-LLMWLLKSSG---IIANRP 676
            :||::|:.....|..|..|:|:.||..|::         |..:.| :.....:.:|   ::|:..
  Fly   841 VVQLIVIELNLALLGSLLASFVSLALFLYL---------SNMSVPDVHASTTERNGPGQVVASSR 896

Human   677 WPRISLTIITTAIILMMAVFNMFFLSDSEETIP------PTANTT--NTSFSA--SNNQVAILRA 731
            :.|:::.::...:|...|||::.     ..|:|      |::|.|  .::||:  .|:.:..::.
  Fly   897 YLRLAMFVVVNILISSCAVFSVI-----NYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQL 956

Human   732 QNLFF----LPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVL 792
            ..:.:    .|.|:|.|.:.|.:.|.|||..:.||::.|:||::...|:|         .||. |
  Fly   957 WEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVL---------GYSD-L 1011

Human   793 FERPGIWKD--------LKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETME 849
            ||   ::.|        |:..|.:.|.:..:.|..|.||.||..|.|||||.|.|.|:||:|||.
  Fly  1012 FE---MYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMR 1073

Human   850 NLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLR 914
            .:|::||||:||||||.|||... ::.||||:||.||.|||||||::||||.|:||||:||||||
  Fly  1074 GINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLR 1137

Human   915 LLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGL-----SAVPSQEHSQEPERQYMHIGTMV 974
            ||||||.|||.||.||||||:||||||.||||.|:||     ....|:..:.|...:..::..:|
  Fly  1138 LLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILV 1202

Human   975 EFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDK 1039
            |||.||:..||:||:.||..|:||:|:||||||||||||||||||||.|||||||||||.||:.:
  Fly  1203 EFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGR 1267

Human  1040 IQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL 1084
            :|.||.|:.:|.|.||.|.|||:..|||||:|.||||.|.....|
  Fly  1268 LQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDGKL 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	173/477 (36%)
		Guanylate_cyc	281..465	CDD:425528	118/183 (64%)
		Adcy_cons_dom	495..600	CDD:461877	21/104 (20%)
		Guanylate_cyc	878..1077	CDD:425528	131/203 (65%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		15/16 (94%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		1/2 (50%)
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	169/425 (40%)
		Guanylate_cyc	310..469	CDD:425528	106/158 (67%)
		Guanylate_cyc	1101..1305	CDD:425528	131/203 (65%)