DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCY2 and Ac76E

DIOPT Version :9

Sequence 1:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens
Sequence 2:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster

Alignment Length:	1345	Identity:	443/1345 - (32%)
Similarity:	656/1345 - (48%)	Gaps:	354/1345 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    12 LRDRSEEAAGG-------GDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALG 69
            |.|.||:..|.       .|...|.|..|.:|.:    :..|:..||..|         |...:|
  Fly    50 LADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLF----RSGLLTSLLACV---------VSIIIG 101

Human    70 LEVEDHVAFLITVPTALAIFFAIF---ILVCIESVFKKLLRLFSLVIWICLV---AMGYLFMCFG 128
            :....|:     |.|.|.:..|:.   ||..::  |..:|...:..:...:|   ::|.:....|
  Fly   102 IVYGQHL-----VQTMLLVLAALISGSILTALQ--FPAVLSSPAAALAFAIVTTFSLGTIAAITG 159

Human   129 GTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILA 193
            ..::|....:.||    .:::|||.:...:::.::..::.|.:..   :..:|....:|. .:..
  Fly   160 DELAPLPMYALFL----CIHSMLPISWPVSVVLALFMTAIHIVYR---IGTSPDYAPNLP-MLFG 216

Human   194 NVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKA 258
            .:::....:::|.|::.:.:.|..:|...|...|:.|:|||.|:.|||:||||::||:||.|:|.
  Fly   217 EIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKR 281

Human   259 EIIQRLQG--PKAGQMENTN--NFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELF 319
            .|:.::..  .:||...:|:  .||.|:|:|||||:||:||||.||.|:|..:..:||..||:||
  Fly   282 SIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLF 346

Human   320 GKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRV 384
            |:|||||:||:|:||||||||||||||||||.|.||.|||.|||.|.:||:.||:|||::::||:
  Fly   347 GRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRI 411

Human   385 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIR 449
            |:|:|||||||:||:|||:||||.|||||||||:|||.|||||:..||:.|...::||:|:|..|
  Fly   412 GIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNR 476

Human   450 DPYLKQHLVKTYFVINPK----------------------------------------------- 467
            |.||..|.|::|.::.||
  Fly   477 DAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLP 541

Human   468 ----------GERRSPQHL---------------------------------------------- 476
                      .|:.||..:
  Fly   542 VTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDG 606

Human   477 ----------------------------------------------------------------- 476

  Fly   607 KNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPT 671

Human   477 ---------------------------------FRPRHTLDGA---------------------- 486
                                             |..|....||
  Fly   672 AAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHV 736

Human   487 -KMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFE 550
             :.|.|.:||:|:|.|||.:|||::  .:|...:|  |....:.|.:.|.      ...::|.|.
  Fly   737 TRNRPSSKMTKYVECWGADRPFANI--AESKLVKN--IGLASIAMIESNL------LPPERKCFN 791

Human   551 EELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIF 615
            ...                :....:::..::.:.|...|..|||.....|::.:.||.::|..:.
  Fly   792 FNF----------------FGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLA 840

Human   616 IVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP-LLMWLLKSSG---IIANRP 676
            :||::|:.....|..|..|:|:.||..|::         |..:.| :.....:.:|   ::|:..
  Fly   841 VVQLIVIELNLALLGSLLASFVSLALFLYL---------SNMSVPDVHASTTERNGPGQVVASSR 896

Human   677 WPRISLTIITTAIILMMAVFNMFFLSDSEETIP------PTANTT--NTSFSA--SNNQVAILRA 731
            :.|:::.::...:|...|||::.     ..|:|      |::|.|  .::||:  .|:.:..::.
  Fly   897 YLRLAMFVVVNILISSCAVFSVI-----NYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQL 956

Human   732 QNLFF----LPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVL 792
            ..:.:    .|.|:|.|.:.|.:.|.|||..:.||::.|:||::...|:|         .||. |
  Fly   957 WEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVL---------GYSD-L 1011

Human   793 FERPGIWKD--------LKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETME 849
            ||   ::.|        |:..|.:.|.:..:.|..|.||.||..|.|||||.|.|.|:||:|||.
  Fly  1012 FE---MYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMR 1073

Human   850 NLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLR 914
            .:|::||||:||||||.|||... ::.||||:||.||.|||||||::||||.|:||||:||||||
  Fly  1074 GINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLR 1137

Human   915 LLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGL-----SAVPSQEHSQEPERQYMHIGTMV 974
            ||||||.|||.||.||||||:||||||.||||.|:||     ....|:..:.|...:..::..:|
  Fly  1138 LLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILV 1202

Human   975 EFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDK 1039
            |||.||:..||:||:.||..|:||:|:||||||||||||||||||||.|||||||||||.||:.:
  Fly  1203 EFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGR 1267

Human  1040 IQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL 1084
            :|.||.|:.:|.|.||.|.|||:..|||||:|.||||.|.....|
  Fly  1268 LQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDGKL 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	53/232 (23%)
		CYCc	236..439	CDD:214485	127/206 (62%)
		Guanylate_cyc	281..465	CDD:278633	118/183 (64%)
		DUF1053	495..599	CDD:283888	21/103 (20%)
		CYCc	848..1056	CDD:214485	133/212 (63%)
		Guanylate_cyc	878..1077	CDD:278633	131/203 (65%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		15/16 (94%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/2 (50%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	57/249 (23%)
		CYCc	259..467	CDD:214485	127/207 (61%)
		Guanylate_cyc	311..469	CDD:278633	105/157 (67%)
		BASP1	510..667	CDD:283191	3/156 (2%)
		CYCc	1079..1283	CDD:214485	130/204 (64%)
		Guanylate_cyc	1101..1305	CDD:278633	131/203 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1788
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75133
Inparanoid	1	1.050	733	1.000	Inparanoid score	I607
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46595
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	1	1.000	-	-		FOG0002139
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4464
SonicParanoid	1	1.000	-	-		X1422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870