Protein Alignment ADCY2 and ACXC

DIOPT Version :10

• Sequence 1: NP_065433.2
• Gene: ADCY2 / 108
• HGNCID: 233
• Length: 1091
• Species: Homo sapiens
• Sequence 2: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Alignment Length: 1182
• Identity: 324/1182 - (27%)
• Similarity: 533/1182 - (45%)
• Gaps: 202/1182 - (17%)

Human     1 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPL--IVFLLLIVMGSCLALL- 62
            :|:.:     |||::.:|       |....::.|.....|.....:  ::|::|.:....:.||
  Fly    30 LWEHS-----YLREKCKE-------LNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLY 82

Human    63 -----AVFFALGLEVEDHVAFLITVPTALAIFFA---------IFILVCIESVFKKLLRLFSLVI 113
                 ||||...:    .|...|.|.|.|:|.|.         :.|...:.||:        ||:
  Fly    83 VQHYNAVFFNFVI----RVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVY--------LVV 135

Human   114 WICLVAMGYLFMCFGGTVSPWD-QVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVL---- 173
            ...:|.:.|.|.     .:.|. ..||.:|.:.::|..||.   .:|..:.|.:||.:::.
  Fly   136 LTDIVMISYHFY-----KNDWPLNTSFDVFTLCMIYMFLPI---PSIKGAALLASSVSLIYVAFF 192

Human   174 --SVCLSATPGGKEHLVWQILANVIIFICG-NLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEF 235
              |:..:|....::...:.:::..|:...| |:.|.:.:.:.:..::.::.|....|.....|..
  Fly   193 MHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRH 257

Human   236 EKRQQERLLLSLLPAHIAM----EMKAEIIQRLQGPKAGQM--ENTNNFHNLYVKRHTNVSILYA 294
            ...|:..||.|:||..||.    ::|::|.|....|...||  ..|.:|  :.::.|.:||||||
  Fly   258 ALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESF--MAIQIHPDVSILYA 320

Human   295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCV 359
            |:|.:|.|.:..:.|.||.:|::|:|:||..|...:..|||.||||||||:||....|:|||.||
  Fly   321 DVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCV 385

Human   360 KMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424
            .:|:.|...|::||...|:||:||:|||||::|.|:||..|.|:|:|..||.:|||:|:.|.||.
  Fly   386 SLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGY 450

Human   425 VHISSVTLEHLNGA-YKVEEGDGDIR-DPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAK 487
            ||:|..||..||.| |.:..|....: ||.|:  .:.||.:   .|:......:     |..|..
  Fly   451 VHVSGRTLSMLNPADYTILSGTQKAQSDPVLQ--YIHTYLL---TGQVARESFI-----TSIGGV 505

Human   488 MRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN---RTLRTKSQKKRF 549
            ..:||...:.::...:::|     .:.|||.| .:....::|:|..|..:   |..|..:.||
  Fly   506 RSSSVLEVKSIDRIRSSRP-----SQSSMTDE-FREEFRNMPVGGINLNSPCCRRTRLDTHKK-- 562

Human   550 EEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCI 614
                                  ...:|......|.:..||..|.......||..:..|..|..|:
  Fly   563 ----------------------TQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCL 605

Human   615 FIVQILV--LPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPW 677
            ..:||:.  ...|:.:.:.....|.|.:.:   |.|.....|..|:......:......:|...:
  Fly   606 IYIQIVTNNFSCTACIVVDLVTFFFLTSLL---CLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIF 667

Human   678 PRIS------LTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQ---N 733
            .:|.      :|:....:....||.::..|           |.....:..|..:..|...:   :
  Fly   668 EKIQHSVSLRITVYLGILFSYYAVISLIML-----------NCDRDMYELSYIESKIYHYEMDRD 721

Human   734 LFFLPYF---IYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFER 795
            ..|.|:.   :.|.|||:  ...|.|:.:.||::|.....:.|..|:....|.:   :.......
  Fly   722 TCFHPWVFTNMISLILGI--SYTFARIPFGLKIVISCCETLAYLLIVFFQFAFI---FQHSATTT 781

Human   796 PGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVL 860
            |.:..:|  ...:.:.:..:|:....||:|:..::::......:.:::..:.......:||.|:|
  Fly   782 PFMKAEL--AHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNIL 844

Human   861 PAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDD 925
            |:||.:.:| .||...|||:::|..|.||||.:.:|          ...|..||:||:||..||.
  Fly   845 PSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINF----------PMNLPSLRVLNDIITQFDR 898

Human   926 LLSK-PKFSGVEKIKTIGSTYMAATGL-----SAVPSQEHSQ------EPERQYMH--------- 969
            ||:. .::..|||||.:|.|||||.||     |.:...:|.:      |.|....|
  Fly   899 LLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDS 963

Human   970 -------IGTMVEFAFALVGKLDAINK--------HSFNDFKLRVGINHGPVIAGVIGAQKPQYD 1019
                   :..|..||..|:..|.|.|:        .|.:..|:.:||:.|.::|||:||.:|.||
  Fly   964 DMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYD 1028

Human  1020 IWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTE----- 1079
            ||||.||:||||:|||:...||||||::.:||.....|..||:..|||:||:.||||..:
  Fly  1029 IWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKF 1093

Human  1080 -----MSRSLSQ 1086
                 ::||||:
  Fly  1094 MSAKLVNRSLSR 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY2	NP_065433.2	AcyC	59..470	CDD:441717	144/441 (33%)
		Guanylate_cyc	281..465	CDD:425528	86/185 (46%)
		Adcy_cons_dom	495..600	CDD:461877	17/107 (16%)
		Guanylate_cyc	878..1077	CDD:425528	90/234 (38%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	905..922		7/16 (44%)
		Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769	990..993		1/2 (50%)
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	79/158 (50%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	89/233 (38%)