DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L1 and Kat60

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	233	Identity:	86/233 - (36%)
Similarity:	130/233 - (55%)	Gaps:	14/233 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   329 DPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLP-KGILLVGPPGTGKTLLARA 391
            ||    .|.:..:..:.:||:.|:|.|.. :..|..|.  |.:.| ||:|:|||||||||:||:|
  Fly   320 DP----KVRWSDIADLHDAKRLLEEAVVLPMLMPDYFK--GIRRPWKGVLMVGPPGTGKTMLAKA 378

Human   392 VAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYS 456
            ||.|....|:..|.:.....:.|.....:|.||..|:..||..|||||:||:..:|.....|..|
  Fly   379 VATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRRGSESEHEAS 443

Human   457 RQTINQLLAEMDGFKPNEG----VIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILK 517
            |:..::||.:|||....|.    |:::.|||||..:|.||.|  |.:.::.:|.|..:||..:||
  Fly   444 RRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSDEGREALLK 506

Human   518 WYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAAL 555
            ..|.::|.|.|||...:|....|:|||::.|:..:|::
  Fly   507 INLREVKVDDSVDLTYVANELKGYSGADITNVCREASM 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	27/65 (42%)
		FtsH_fam	333..766	CDD:273520	84/229 (37%)
		AAA	375..506	CDD:278434	53/134 (40%)
		Peptidase_M41	586..764	CDD:279742
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	25/57 (44%)
		AAA	358..496	CDD:214640	57/139 (41%)
		AAA	362..495	CDD:278434	53/134 (40%)
		Vps4_C	<570..603	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910