Protein Alignment YME1L1 and comt

DIOPT Version :9

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_001259506.1
• Gene: comt / 47091
• FlyBaseID: FBgn0000346
• Length: 745
• Species: Drosophila melanogaster
• Alignment Length: 669
• Identity: 164/669 - (24%)
• Similarity: 263/669 - (39%)
• Gaps: 193/669 - (28%)

Human   218 LQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMKTKNIP---EAHQDAFK-TGFAEGFLK 278
            |:.|.|        .||...||.|..|...:.|:::.::.:  |   :|..|... ..|...||:
  Fly    49 LEKTVE--------VPSGYVGFSLVQRKWAMVSINQELEVR--PYRFDASSDVITCVSFETDFLQ 103

Human   279 AQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLD------SAVDP------- 330
            .:.::|:..||.:..:  .|::...|: .|.....|...|:....|.      .|:||
  Fly   104 KKTVSQEPYDSDQMAK--EFIMQFAGM-ALTVGQSLVFNFKDKKLLGLAVKSLEAIDPKSLGEGK 165

Human   331 -VQMKNVTFEHVKG--------VEEAKQELQ-----EVV-EFLKNPQ----KFTI---------- 366
             ..|:||.|..:.|        .|.:...||     :|| :.:.||.    |..|
  Fly   166 DTAMRNVRFGRILGNTVVQFEKAENSSLNLQGKSKGKVVRQSIINPDWDFGKMGIGGLDKEFNSI 230

Human   367 -----------------LGGKLPKGILLVGPPGTGKTLLARAV-----AGEADVPFYYASGSEFD 409
                             ||.|..|||||.|||||||||:||.:     |.|..:    .:|.:..
  Fly   231 FRRAFASRVFPPELVEQLGCKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI----VNGPQIL 291

Human   410 EMFVGVGASRIRNLFREA----KANAP----CVIFIDELDSV----GGKRIESPMHPYSRQTINQ 462
            :.:||...:.:|.||.||    |...|    .:|..||:|::    |.....|.:|.   ..:||
  Fly   292 DKYVGESEANVRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKQRGSVAGNSGVHD---TVVNQ 353

Human   463 LLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKI---- 523
            ||.::||......:::||.||..:.:|.||:||||.::|:.:..|:.:||.:||..:..::
  Fly   354 LLTKIDGVDQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMREFN 418

Human   524 KFDQSVDPEIIARGTVGFSGAELENLVNQAALKA-----AVDGKEMV---TMKELEFSKDKILMG 580
            |.:..||.:.||..|..|||||||.||..|...|     ..|.|..|   .|::|:.::|..|
  Fly   419 KINDDVDNKEIAALTKNFSGAELEGLVRAAQSSAMNRLIKADAKVTVDPEAMEKLKVNRDDFL-- 481

Human   581 PERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRA 645
               .|:|.|.|                                  |..|....:.:|
  Fly   482 ---HSLEHDIK----------------------------------PAFGTAQEILDN-------- 501

Human   646 QLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVT------KFGMSEKLGVMTYS 704
             :||:..::.|..|:..|..|..::....:.:......:   :|.      |..::.:|..|:..
  Fly   502 -MLARGVINWGAPVSNLLEDGMLYVQQAKAPESSGLVSV---LVAGAPNSGKTALAAQLAKMSDF 562

Human   705 DTGKL-SPE-----TQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQI 763
            ...|: |||     |:||....||.:..|:|   :.:|.....::   .|.||.|.::..:...:
  Fly   563 PFVKVCSPEDMVGYTESAKCLHIRKIFDDAY---RSMLSCIVVDN---VERLLDYGSIGPRYSNM 621

Human   764 VLE------------GKKL 770
            .|:            |:||
  Fly   622 TLQALLVLLKKQPPKGRKL 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	34/113 (30%)
		FtsH_fam	333..766	CDD:273520	132/518 (25%)
		AAA	375..506	CDD:278434	51/147 (35%)
		Peptidase_M41	586..764	CDD:279742	32/189 (17%)
comt	NP_001259506.1	CDC48_N	5..83	CDD:215012	10/43 (23%)
		CDC48_2	111..>158	CDD:215011	9/49 (18%)
		SpoVK	242..699	CDD:223540	122/463 (26%)
		AAA	256..397	CDD:278434	51/147 (35%)
		AAA	539..668	CDD:278434	24/111 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910