DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L1 and Rpt2

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_001287493.1	Gene:	Rpt2 / 42828	FlyBaseID:	FBgn0015282	Length:	439	Species:	Drosophila melanogaster

Alignment Length:	406	Identity:	117/406 - (28%)
Similarity:	199/406 - (49%)	Gaps:	45/406 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   185 HSRA------LQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRD 243
            |:|.      |:.|...|.....||:::         .||:...|:..|.::....      ||.
  Fly    54 HTRCRLKLLKLERIKDYLMMEDEFIRNQ---------ERLKPQDEKNEEERSKVDD------LRG 103

Human   244 RGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGL 308
            ....|.:|:::     |.:.|.....:..:|.::...:...|  |.|.....:|....:..:.|:
  Fly   104 TPMSVGNLEEI-----IDDNHAIVSTSVGSEHYVSILSFVDK--DQLEPGCSVLLNHKVHAVVGV 161

Human   309 LKNPFLSVRFRTTTGLDSAVDPVQMKNV---TFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGG 369
            |.:           ..|..|..::::..   |:..:.|::...||::|.||. |.:|:.:..:|.
  Fly   162 LSD-----------DTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGI 215

Human   370 KLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCV 434
            |.|||::|.|||||||||||:|||.:....|....|||..:.::|.|...:|.|||.|:.:||.:
  Fly   216 KPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSI 280

Human   435 IFIDELDSVGGKRIESPM--HPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGR 497
            :||||:|:||.||.:|..  ....::|:.:||.::|||.....|.:|.|||..|.||.|||||||
  Fly   281 VFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGR 345

Human   498 FDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGK 562
            .|.::..|.||.|.:..|...:.:::...:.|:...:.......|||:::.:..:|.|.|..:.:
  Fly   346 IDRKIEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERR 410

Human   563 EMVTMKELEFSKDKIL 578
            ..||.::.:.||:.:|
  Fly   411 MKVTNEDFKKSKESVL 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	29/67 (43%)
		FtsH_fam	333..766	CDD:273520	91/252 (36%)
		AAA	375..506	CDD:278434	60/132 (45%)
		Peptidase_M41	586..764	CDD:279742
Rpt2	NP_001287493.1	PTZ00361	1..439	CDD:185575	117/406 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910