Protein Alignment YME1L1 and Rpt2

DIOPT Version :10

• Sequence 1: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_524469.2
• Gene: Rpt2 / 42828
• FlyBaseID: FBgn0015282
• Length: 439
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 117/406 - (28%)
• Similarity: 199/406 - (49%)
• Gaps: 45/406 - (11%)

Human   185 HSRA------LQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRD 243
            |:|.      |:.|...|.....||:::         .||:...|:..|.::....      ||.
  Fly    54 HTRCRLKLLKLERIKDYLMMEDEFIRNQ---------ERLKPQDEKNEEERSKVDD------LRG 103

Human   244 RGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGL 308
            ....|.:|:::     |.:.|.....:..:|.::...:...|  |.|.....:|....:..:.|:
  Fly   104 TPMSVGNLEEI-----IDDNHAIVSTSVGSEHYVSILSFVDK--DQLEPGCSVLLNHKVHAVVGV 161

Human   309 LKNPFLSVRFRTTTGLDSAVDPVQMKNV---TFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGG 369
            |.:           ..|..|..::::..   |:..:.|::...||::|.||. |.:|:.:..:|.
  Fly   162 LSD-----------DTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGI 215

Human   370 KLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCV 434
            |.|||::|.|||||||||||:|||.:....|....|||..:.::|.|...:|.|||.|:.:||.:
  Fly   216 KPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSI 280

Human   435 IFIDELDSVGGKRIESPM--HPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGR 497
            :||||:|:||.||.:|..  ....::|:.:||.::|||.....|.:|.|||..|.||.|||||||
  Fly   281 VFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGR 345

Human   498 FDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGK 562
            .|.::..|.||.|.:..|...:.:::...:.|:...:.......|||:::.:..:|.|.|..:.:
  Fly   346 IDRKIEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERR 410

Human   563 EMVTMKELEFSKDKIL 578
            ..||.::.:.||:.:|
  Fly   411 MKVTNEDFKKSKESVL 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	HflB	<332..767	CDD:440233	91/253 (36%)
Rpt2	NP_524469.2	PTZ00361	1..439	CDD:185575	117/406 (29%)