DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L1 and Rpt3R

DIOPT Version :9

Sequence 1:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens
Sequence 2:	NP_649938.2	Gene:	Rpt3R / 41190	FlyBaseID:	FBgn0037742	Length:	405	Species:	Drosophila melanogaster

Alignment Length:	257	Identity:	90/257 - (35%)
Similarity:	145/257 - (56%)	Gaps:	19/257 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   326 SAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLA 389
            |.:.|.:..::::..:.|::..|||::|.||. |.:.|.:..:|...|:|:||.||||.|||:||
  Fly   139 SMLSPDEKPDISYSDIGGLDIQKQEIREAVELPLTHAQLYKQIGIDPPRGVLLFGPPGCGKTMLA 203

Human   390 RAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHP 454
            :|||......|....||||.:.::|.|...:|:|||.||.|:|.:|||||:|::..||.::
  Fly   204 KAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDLFRLAKQNSPSIIFIDEIDAIATKRFDA---- 264

Human   455 YSRQT---------INQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVK 510
               ||         :.:||.:||||.....:.:|.|||..:.||.||:||||.|.::.:|.||.:
  Fly   265 ---QTGADREVQRILLELLNQMDGFDETTNIKVIMATNRADTLDPALLRPGRLDRKIELPLPDRR 326

Human   511 GRTEILKWYLNKIKFDQSVDPE-IIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELE 571
            .:..:.....:|:...:.||.| ||||.. ..|.|::..:..:|.:.|..:.:.:|..|:.|
  Fly   327 QKRLVFTTITSKMNVGEDVDLEDIIARPD-KISNADINAICQEAGMHAVRENRYVVNAKDFE 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	26/64 (41%)
		FtsH_fam	333..766	CDD:273520	88/250 (35%)
		AAA	375..506	CDD:278434	58/139 (42%)
		Peptidase_M41	586..764	CDD:279742
Rpt3R	NP_649938.2	PTZ00454	20..405	CDD:240423	90/257 (35%)
Rpt3R	NP_649938.2	AAA	189..322	CDD:278434	58/139 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910